Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis

Environmental and Molecular Mutagenesis

Volumn 39, Issue 2-3, 2002, Pages 178-183

  Medina, Daniel ^a   Ullrich, Robert ^b   Meyn, Raymond ^c   Wiseman, Roger ^d   Donehower, Larry ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Environmental agents; Hormones; Mammary; P53

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; CARCINOGEN; DIMETHYLBENZ[A]ANTHRACENE; ENVIRONMENTAL CHEMICAL; ENVIRONMENTAL MUTAGEN; GENE PRODUCT; MITOGENIC AGENT; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROTEIN P53; STEROID HORMONE;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; BREAST CANCER; BREAST CARCINOGENESIS; CARCINOGENICITY; COCARCINOGENESIS; CONFERENCE PAPER; CONTROLLED STUDY; DNA MICROARRAY; GAMMA RADIATION; GENE TECHNOLOGY; HETEROZYGOSITY; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; NULL ALLELE; ONCOGENE H RAS; RADIATION CARCINOGENESIS; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; BRCA2 PROTEIN; CARCINOGENS, ENVIRONMENTAL; FEMALE; GENES, P53; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, TRANSGENIC; PROGESTERONE; RADIATION DOSAGE;

MOUSE MAMMARY TUMOR VIRUS; MUS MUSCULUS;

EID: 0036208294     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.10064     Document Type: Conference Paper

References (28)

1. Tyrosine kinase signalling in breast cancer: Tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer
2. The role of p53 in tumor suppression: Lessons from mouse models
3. Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol
4. c-H-ras-1 expression in 7,12-dimethylbenzathracene-induced BALB/c mouse mammary hyperplasias and their tumors
5. Genetically engineered mouse models of mammary intraepithelial neoplasia
6. Acceleration of mammary neoplasia in transforming growth factor alpha transgenic mice by 7,12-dimethylbenzanthracene
7. c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations
8. Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells
9. Hormonal prevention of breast cancer: Mimicking the protective effect of pregnancy
10. p53 mutations occur infrequently in 7,12-dimethylbenzanthracene-induced mammary tumors in BALB/c and hemizygous p53 mice
11. A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development
12. Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis
13. Activation of H-ras oncogenes in preneoplastic mouse mammary tissues
14. Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice
15. A transgenic mouse model for mammary carcinogenesis
16. Chemical factors in mammary tumorigenesis
17. Evaluation of survival data and two new rank order statistics arising in its consideration
18. The effects of hormone stimulation, dose and time of administration on carcinogen-induced tumors from preneoplastic nodule outgrowths
19. Mouse models for mammary cancer
20. Enhancement of tumorigenicity with morphological progression in a BALB/c preneoplastic outgrowth line
21. Radiation-induced tumorigenesis in preneoplastic mouse mammary glands in vivo; significance of p53 status and apoptosis
22. Signal transduction in mammary development and tumorigenesis
23. A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model
24. Guidelines in the analysis of tumor rates and death rates in experimental animals
25. Effect of hormone replacement therapy on breast cancer risk: Estrogen versus estrogen plus progestin
26. Strain-dependent susceptibility to radiation-induced mammary cancer is a result of differences in epithelial cell sensitivity to transformation
27. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
28. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation