Disruption of Brca2 increases the spontaneous mutation rate in vivo: Synergism with ionizing radiation

EMBO Reports

Volumn 3, Issue 3, 2002, Pages 255-260

  Tutt, Andrew N J ^a   van Oostrom, Conny Th M ^a   Ross, Gillian M ^a   van Steeg, Harry ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; BRCA2 PROTEIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; FEMALE; GENETIC CODE; HETEROZYGOTE; HOMOZYGOSITY; IN VIVO STUDY; IONIZING RADIATION; MAMMOGRAPHY; MOUSE; MUTATION RATE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RADIATION EXPOSURE; REPORTER GENE; SOMATIC MUTATION; TRANSGENE; WILD TYPE;

ANIMALS; FEMALE; GENE DELETION; GENES, BRCA2; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; MUTAGENESIS; RADIATION, IONIZING;

ANIMALIA;

EID: 0036209073     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf037     Document Type: Article

References (23)

1. Breast cancer: Genetic predisposition and exposure to radiation
2. Plasmid-based transgenic mouse model for studying in vivo mutations
3. Recommendations for follow-up care of individuals with an inherited predisposition to cancer. II. BRCA1 and BRCA2. Cancer Genetics Studies Consortium
4. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
5. Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations
6. Rapid accumulation of genome rearrangements in liver but not in brain of old mice
7. Background mutations and polymorphisms in lacZ-plasmid transgenic mice
8. Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine
9. Roads to breast cancer
10. Current perspectives on radiation-induced breast cancer
11. Spontaneous and X-ray-induced deletion mutations in a LacZ plasmid-based transgenic mouse model
12. Radiation carcinogenesis
13. Chromosome breaks and genomic instability
14. DNA double strand break repair in mammalian cells
15. New complexities for BRCA1 and BRCA2
16. Genetic instabilities in human cancers
17. Mutator phenotype may be required for multistage carcinogenesis
18. BRCA2 is required for homology-directed repair of chromosomal breaks
19. The genetics of breast cancer susceptibility
20. 60Co
21. First experiences in screening women at high risk for breast cancer with MR imaging
22. Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences
23. Bacteriophage lambda and plasmid Lacz transgenic mice for studying mutations in vivo