Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome

Nature

Volumn 408, Issue 6814, 2000, Pages 881-884

  Yean, S L ^a   Wuenschell, G ^a   Termini, J ^a   Lin, R J ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM ION; MANGANESE; METAL ION; NUCLEAR RNA; NUCLEOTIDE; OXYGEN; SULFUR;

ARTICLE; CATALYSIS; ESTERIFICATION; INTRON; METAL BINDING; PRIORITY JOURNAL; REACTION ANALYSIS; RNA SPLICING; SPLICEOSOME; YEAST;

CATALYSIS; ESTERS; MAGNESIUM; MANGANESE; RNA PRECURSORS; RNA SPLICING; RNA, FUNGAL; RNA, MESSENGER; RNA, SMALL NUCLEAR; SPLICEOSOMES; THIONUCLEOTIDES; YEASTS;

EID: 0034649666     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35048617     Document Type: Article

References (30)

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9. 2-) in aqueous solution
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15. Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing
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18. Metal ion catalysis in the Tetrahymena ribozyme reaction
19. A second catalytic metal ion in group 1 ribozyme
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22. Metal coordination sites that contribute to structure and catalysis in the group I intron from Tetrahymena
23. Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme
24. Catalytic site components common to both splicing steps of a group II intron
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29. Site-specific modification of pre-mRNA: The 2′-hydroxyl groups at the splice sites