Control of branch-site choice by a group II intron

EMBO Journal

Volumn 20, Issue 23, 2001, Pages 6866-6876

  Chu, Vi T ^a,b   Adamidi, Catherine ^a   Liu, Qiaolian ^a   Perlman, Philip S ^c   Pyle, Anna Marie ^a  

^a Columbia University ^*  (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Catalysis; Group II introns; Ribozyme; Spliceosome; Splicing

Indexed keywords

ADENOSINE;

3' UNTRANSLATED REGION; ARTICLE; BASE PAIRING; CATALYSIS; INTRON; MOLECULAR RECOGNITION; MUTATION; PRIORITY JOURNAL; RNA SPLICING; SPLICEOSOME;

BASE SEQUENCE; DNA REPLICATION; HYDROLYSIS; INTRONS; KINETICS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; PHYLOGENY; PLASMIDS; RNA SPLICING; RNA, CATALYTIC; RNA, MESSENGER; SPLICEOSOMES;

EID: 0035803594     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.23.6866     Document Type: Article

References (48)

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3. Length changes in the joining segment between domain 5 and 6 of a group II intron inhibit self-splicing and alter 3′ splice site selection
4. Thermodynamics of unpaired terminal nucleotides on short RNA helices correlates with stacking at helix termini in larger RNAs
5. The generality of self-splicing RNA: Relationship to nuclear mRNA splicing
6. An RNA conformational change between the two chemical steps of group II self-splicing
7. Branch-point attack in group II introns is a highly reversible transesterification, providing a possible proofreading mechanism for 5′-splice site selection
8. More than one way to splice an RNA: Branching without a bulge and splicing without branching in group II introns
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11. Cloning and expression of the gene for bacteriophage T7 DNA
12. Domain 5 interacts with domain 6 and influences the second transesterification reaction of group II intron self-splicing
13. Distribution of cognates of group II introns detected in mitochondrial cox1 genes of a diatom and a haptophyte
14. Functional group substitutions of the branchpoint adenosine in a nuclear pre-mRNA and a group II intron
15. A major family of motifs involving G-A mismatches in ribosomal RNA
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20. Enzymatic RNA sequencing
21. Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast
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24. A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome
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28. Comparative and functional anatomy of group II catalytic introns - A review
29. Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro
30. Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites
31. Alternative splicing of SV40 pre-mRNA is determined by branch-site selction
32. Lariat RNAs as intermediates and products in the splicing of messenger RNA precursors
33. A self-splicing RNA excises an intron lariat
34. Photocrosslinking of 4-thio uracilcontaining RNAs supports a side-by-side arrangement of domains 5 and 6 of a group II intron
35. Group II intron splicing in vivo by first-step hydrolysis
36. Using DNAzymes to cut, process and map RNA molecules for structural studies or modification
37. The architectural organization and mechanistic function of group II intron structural elements
38. Branch nucleophile selection in pre-mRNA splicing: Evidence for the bulged duplex model
39. Three recognition events at the branch-site adenine
40. Cryptic branch point activation allows accurate in vitro splicing of human β-globin intron mutants
41. Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae
42. A novel U2-U6 snRNA structure is necessary for splicing
43. Excised group II introns in yeast mitochondria are lariats and can be formed by self-splicing in vitro
44. Mutations at the lariat acceptor site allow self-splicing of a group II intron without lariat formation
45. Efficient integration of an intron RNA into double-stranded DNA by reverse-splicing
46. U6 snRNA function in nuclear pre-mRNA splicing: A phosphorothioate interference analysis of the U6 phosphate backbone