Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme

Science

Volumn 286, Issue 5437, 1999, Pages 123-126

  Perrotta, Anne T ^a   Shih, I Hung ^a   Been, Michael D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOSINE; IMIDAZOLE; RIBONUCLEOPROTEIN; RIBOZYME;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; GENE MUTATION; HEPATITIS DELTA VIRUS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; RNA CLEAVAGE;

BINDING SITES; CATALYSIS; CYTOSINE; HEPATITIS DELTA VIRUS; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; MAGNESIUM CHLORIDE; MANGANESE; MUTAGENESIS; POINT MUTATION; PROTONS; PYRAZOLES; RNA, CATALYTIC; TEMPERATURE;

DELTA VIRUS; HEPATITIS DELTA VIRUS; RNA VIRUSES;

EID: 0033215448     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5437.123     Document Type: Article

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31. Supported by NIH grant GM47322. We thank T. Cech, S. Crary, C. Fierke, D. Herschlag, T.-s. Hsieh, and T. Wadkins for critical comments and helpful suggestions.