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Volumn 119, Issue 27, 1997, Pages 6259-6268

Dynamics of thermal motions within a large catalytic RNA investigated by cross-linking with thiol-disulfide interchange

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; RIBOZYME; RNA; THIOL;

EID: 0030805544     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9707421     Document Type: Article
Times cited : (71)

References (58)
  • 18
    • 16944364948 scopus 로고    scopus 로고
    • note
    • The pyridyl disulfide (4) displayed only limited stability. Use of this disulfide also prevented inhibition of cross-linking at low pH; its reactivity increased at pH < 7 as a result of protonation of the pyridine nitrogen.
  • 19
    • 16944365729 scopus 로고    scopus 로고
    • note
    • For the thiol-disulfide interchange reaction, it is assumed that Δlog k/ΔpH ∼1 in the pH range of 4.5-7.5.
  • 42
    • 0025885722 scopus 로고
    • For examples, see: (a) Young, B.; Herschlag, D.; Cech, T. R. Cell 1991, 67. 1007-1019. (b) Pyle, A. M.; Murphy, F. L.; Cech, T. R. Nature 1992, 358, 123-138.
    • (1991) Cell , vol.67 , pp. 1007-1019
    • Young, B.1    Herschlag, D.2    Cech, T.R.3
  • 43
    • 0026729278 scopus 로고
    • For examples, see: (a) Young, B.; Herschlag, D.; Cech, T. R. Cell 1991, 67. 1007-1019. (b) Pyle, A. M.; Murphy, F. L.; Cech, T. R. Nature 1992, 358, 123-138.
    • (1992) Nature , vol.358 , pp. 123-138
    • Pyle, A.M.1    Murphy, F.L.2    Cech, T.R.3
  • 46
    • 16944362687 scopus 로고    scopus 로고
    • note
    • Because absolute rates of disulfide trapping depend not only on encounter frequency but also on chemical parameters such as leaving group stability, pH, and the presence of a catalyst, the analysis is restricted to relative rates within a given system.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.