Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate

Biochemistry

Volumn 38, Issue 43, 1999, Pages 14363-14378

  Wang, Shenglong ^a   Karbstein, Katrin ^a   Peracchi, Alessio ^a,b   Beigelman, Leonid ^a,c   Herschlag, Daniel ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF PARMA   (Italy)

^c Sirna Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM; METAL ION; PHOSPHOROTHIOIC ACID; RIBOZYME;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; KINETICS; METAL BINDING; MOLECULAR INTERACTION; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; RNA BINDING; RNA CLEAVAGE; STEREOSPECIFICITY;

BASE SEQUENCE; BINDING SITES; CADMIUM; CATALYSIS; CATIONS, DIVALENT; KINETICS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PHOSPHORIC ACID ESTERS; RNA, CATALYTIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIONUCLEOTIDES;

EID: 0033607198     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9913202     Document Type: Article

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