Crystal structure of a group I ribozyme domain: Principles of RNA packing

Science

Volumn 273, Issue 5282, 1996, Pages 1678-1685

  Cate, Jamie H ^a   Gooding, Anne R ^b,c   Podell, Elaine ^b,c   Zhou, Kaihong ^a   Golden, Barbara L ^b,c   Kundrot, Craig E ^b   Cech, Thomas R ^b,c   Doudna, Jennifer A ^a  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOZYME;

ARTICLE; CRYSTAL STRUCTURE; ESTERIFICATION; EXCISION REPAIR; INTRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; RNA METABOLISM; RNA STRUCTURE; SPLICEOSOME; STRUCTURE ANALYSIS; TETRAHYMENA THERMOPHILA;

EID: 0029820625     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.273.5282.1678     Document Type: Article

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76. We thank H. Taube of Stanford University for the osmium hexammine triflate; T. Steitz, S. Schultz, A. Brünger, A. Ferré-d'Amaré, C. Correll, D. Engelman, A. Friedman, T. Griffin, J. Jaeger, A. M. Pyle, V. Rath, L. Rice, L. Silvian, S. Strobel, J. Wang, and members of the Center for Structural Biology at Yale for many helpful discussions; V. Carperos, L. Doherty, A. Ferré-d'Amaré, C. Correll, and J. Jaeger for help with data collection; V. Rath and Pfizer Inc. of Groton, CT, for use of data collection equipment; C. Ogata and W. Hendrickson for useful discussions and data collection time at beamline X-4A at the National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY; the staff at Cornell High Energy Synchrotron Source (CHESS) beamline A-1; A. Thompson and the staff at beamline BL-19 at the European Synchrotron Radiation Facility (ESRF), Grenoble, France; and A. Ferré-d'Amaré, V. Rath, and S. Strobel for review of the manuscript. Supported by the Lucille P. Markey Charitable Trust Scholars Program, the Donaghue Medical Research Foundation, NIH grant GM22778-21, the Searle Scholars Program, and the Beckman Young Investigators Program (J.A.D.), NIH training grant 5T32GM08283-07 (J.H.C.), American Cancer Society postdoctoral fellowship (B.L.G.), NSF grant MCB-9221307 (C.E.K.), Howard Hughes Medical Institute (T.R.C.), and the Keck Foundation (C.E.K. and T.R.C.).