Does a single metal ion bridge the A-9 and scissile phosphate groups in the catalytically active hammerhead ribozyme structure?

Journal of Molecular Biology

Volumn 296, Issue 1, 2000, Pages 33-41

  Murray, James B ^a   Scott, William G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Catalytic RNA; Hammerhead ribozyme; Hammerhead RNA; Ribozyme mechanism; RNA catalysis

Indexed keywords

METAL ION; PHOSPHATE; RIBOZYME; RNA;

ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME STRUCTURE; METAL BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; STEREOCHEMISTRY;

EID: 0034635350     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3428     Document Type: Article

References (24)

1. The global conformation of an active hammerhead RNA during the process of self-cleavage
2. The ion-induced folding of the hammerhead ribozyme: Core sequence changes that perturb folding into the active conformation
3. Ion-induced folding of the hammerhead ribozyme: A fluorescence resonance energy transfer study
4. RNA folding and misfolding of the hammerhead ribozyme
5. Simple RNA enzymes with new and highly specific endoribonuclease activities
6. The structural basis of hammerhead ribozyme self-cleavage
7. The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone
8. Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction
9. New parameters for the refinement of nucleic acid-containing structures
10. Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation
11. A core folding model for catalysis by the hammerhead ribozyme accounts for its extraordinary sensitivity to abasic mutations
12. Three-dimensional structure of a hammerhead ribozyme
13. Autolytic processing of dimeric plant virus satellite RNA
14. The crystal-structure of an all-RNA hammerhead ribozyme - A proposed mechanism for RNA catalytic cleavage
15. Capturing the structure of a catalytic RNA intermediate: The hammerhead ribozyme
16. Probing RNA tertiary structure: Interhelical crosslinking of the hammerhead ribozyme
17. Circular substrates of the hammerhead ribozyme shift the internal equilibrium further toward cleavage
18. A three-dimensional model for the hammerhead ribozyme based on fluorescence measurements
19. A small catalytic oligoribonucleotide
20. Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effects of a cleavage site phosphorothioate
21. Crystallographic structures of the hammerhead ribozyme: Relationship to ribozyme folding and catalysis