A single-molecule study of RNA catalysis and folding

Science

Volumn 288, Issue 5473, 2000, Pages 2048-2051

  Zhuang, Xiaowei ^a   Bartley, Laura E ^b   Babcock, Hazen P ^a   Russell, Rick ^b   Ha, Taekjip ^a   Herschlag, Daniel ^b   Chu, Steven ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOZYME;

ARTICLE; CATALYSIS; ENZYME IMMOBILIZATION; FLUORESCENCE; PRIORITY JOURNAL; PROTEIN FOLDING; RNA ANALYSIS; TETRAHYMENA THERMOPHILA;

ANIMALS; BIOTINYLATION; CARBOCYANINES; CATALYSIS; FLUORESCENT DYES; GUANOSINE; KINETICS; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; OLIGORIBONUCLEOTIDES; RNA, CATALYTIC; RNA, PROTOZOAN; TETRAHYMENA THERMOPHILA;

TETRAHYMENA THERMOPHILA;

EID: 0034674420     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5473.2048     Document Type: Article

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49. We are grateful to S. A. Scaringe and J. A. Orr for their advice on oligonucleotide preparation. This research was supported by an NSF grant (PHY-9970017) and an Air Force Office of Scientific Research grant (F49620-98-1-0219) to S.C. and an NIH grant (GM49423) to D.H. X.Z. was supported by the Chodorow Fellowship of the Stanford Applied Physics Department and an NIH postdoctoral fellowship. L.E.B. was supported in part by an NIH training grant. H.P.B. was supported in part by a Center on Polymer Interfaces and Macromolecular Assemblies grant. R.R. was supported by an NIH postdoctoral fellowship.