Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin

Nature

Volumn 415, Issue 6870, 2002, Pages 396-402

  Drum, Chester L ^a,b   Yan, Shui Zhong ^a   Bard, Joel ^b   Shen, Yue Quan ^a   Lu, Dan ^a   Soelaiman, Sandriyana ^a   Grabarek, Zenon ^b   Bohm, Andrew ^b,c   Tang, Wei Jen ^a,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONFORMATIONS; PATHOLOGY;

ANTHRAX;

PROTEINS;

ADENOSINE TRIPHOSPHATE DERIVATIVE; ADENYLATE CYCLASE; ANTHRAX TOXIN; CALMODULIN; CORDYCEPIN TRIPHOSPHATE; EDEMA FACTOR; EXOTOXIN; HISTIDINE; METAL ION; UNCLASSIFIED DRUG;

BIOCHEMISTRY; PATHOGEN;

ANTHRAX; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; GEOMETRY; MOLECULAR RECOGNITION; MOLECULAR WEIGHT; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; ROTATION; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANIMALS; BACILLUS ANTHRACIS; CALMODULIN; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; EXOTOXINS; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

ANTHRAX; MAMMALIA;

EID: 0037165139     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/415396a     Document Type: Article

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