General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme

Science

Volumn 287, Issue 5457, 2000, Pages 1493-1497

  Nakano, Shu Ichi ^a   Chadalavada, Durga M ^a   Bevilacqua, Philip C ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; BASE; CYTOSINE; DIVALENT CATION; HISTIDINE; METAL ION; MONOVALENT CATION; RIBOZYME; RNA; VIRUS ENZYME;

ARTICLE; CATALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; HEPATITIS DELTA VIRUS; MOLECULAR INTERACTION; NONHUMAN; PH; PKA; PRIORITY JOURNAL;

BASE PAIRING; BINDING SITES; CALCIUM; CATALYSIS; COBALT; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; HEPATITIS DELTA VIRUS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; MAGNESIUM; METALS; MODELS, CHEMICAL; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTONS; RNA, CATALYTIC; RNA, VIRAL; THERMODYNAMICS;

DELTA VIRUS; HEPATITIS DELTA VIRUS;

EID: 0034712097     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.287.5457.1493     Document Type: Article

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52. Supported by NIH grant GM58709. We thank S. Benkovic, M. Bollinger, S. Booker, T. Glass, and members of the Bevilacqua lab for reading the manuscript before publication and for helpful comments, and S. Tan for assistance in preparing Fig. 3B.