New serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor antagonists: Synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones

Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2002, Pages 54-71

  Brea, J ^a   Rodrigo, J ^b   Carrieri, A ^c   Sanz, F ^b   Cadavid, M I ^a   Enguix, M J ^a   Villazon M ^a   Mengod, G ^d   Caro, Y ^a   Masaguer, C F ^a   Ravina E ^a   Centeno, N B ^b   Carotti, A ^c   Loza, M I ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c UNIVERSITY OF BARI   (Italy)

^d INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 1[(1 OXO 1,2,3,4 TETRAHYDRO 3 NAPHTHYL)METHYL] 4 [3 (2 FLUOROBENZOYL)PROPYL]PIPERAZINE; ALKANONE DERIVATIVE; BENZOFURAN DERIVATIVE; BUTYROPHENONE DERIVATIVE; METHYSERGIDE; MIANSERIN; PIPERIDINE DERIVATIVE; SEROTONIN; SEROTONIN 2 ANTAGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2B ANTAGONIST; SEROTONIN 2B RECEPTOR; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; CHO CELL; CHOROID PLEXUS; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; FRONTAL CORTEX; HUMAN; HUMAN CELL; MALE; MOLECULAR MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; RECEPTOR AFFINITY; SEROTONINERGIC SYSTEM; STOMACH FUNDUS;

ANIMALS; AORTA; BUTYROPHENONES; CHO CELLS; CRICETINAE; CYCLOPARAFFINS; FRONTAL LOBE; HETEROCYCLIC COMPOUNDS; HUMANS; LIGANDS; MALE; MODELS, MOLECULAR; MUSCLE, SMOOTH, VASCULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STOMACH;

EID: 0037011897     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011014y     Document Type: Article

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