In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties

British Journal of Pharmacology

Volumn 117, Issue 3, 1996, Pages 427-434

  Kennett, G A ^a   Wood, M D ^a   Bright, F ^a   Cilia, J ^a   Piper, D C ^a   Gager, T ^a   Thomas, D ^a   Baxter, G S ^a   Forbes, I T ^a   Ham, P ^a   Blackburn, T P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT; 5 HT2B; 5 HT2C; Anxiety; m chlorophenylpiperazine; Receptors

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; NEUROTRANSMITTER RECEPTOR; PHOSPHATIDYLINOSITIDE; SEROTONIN 2 ANTAGONIST; SEROTONIN 2B RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; CONFLICT; CONTROLLED STUDY; DRUG SELECTIVITY; FEMALE; HUMAN; HUMAN CELL; HYDROLYSIS; INTRAVENOUS DRUG ADMINISTRATION; LOCOMOTION; MALE; MARMOSET; NONHUMAN; ORAL DRUG ADMINISTRATION; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SOCIAL INTERACTION; STOMACH FUNDUS; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; CALLITHRIX; CELL LINE; CONFLICT (PSYCHOLOGY); FEMALE; HUMANS; INDOLES; KIDNEY; MALE; MOTOR ACTIVITY; PHOSPHATIDYLINOSITOLS; PIPERAZINES; PYRIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SOCIAL BEHAVIOR;

EID: 0030063510     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15208.x     Document Type: Article

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