Synthesis, biological activity, and molecular modeling studies of selective 5-HT(2C/2B) receptor antagonists

Journal of Medicinal Chemistry

Volumn 39, Issue 25, 1996, Pages 4966-4977

  Forbes, Ian T ^a   Dabbs, Steven ^a   Duckworth, D Malcolm ^a   Ham, Peter ^a   Jones, Graham E ^a   King, Frank D ^a   Saunders, Damian V ^a   Blaney, Frank E ^a   Naylor, Christopher B ^a   Baxter, Gordon S ^a   Blackburn, Thomas P ^a   Kennett, Guy A ^a   Wood, Martyn D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 (1 METHYL 5 INDOLYL) 3 (3 PYRIDYL)UREA; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; KETANSERIN; LEUCINE; MESULERGINE; SERINE; SEROTONIN 1C RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG; VALINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY NEUROSIS; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; EMBRYO; FRONTAL CORTEX; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MOLECULAR MODEL; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ANIMALS; FRONTAL LOBE; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PYRIDINES; RADIOLIGAND ASSAY; RATS; SEROTONIN ANTAGONISTS;

EID: 10544248588     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960571v     Document Type: Article

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