Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice

Psychopharmacology

Volumn 129, Issue 1, 1997, Pages 79-84

  Gleason, Scott D ^a   Shannon, Harlan E ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

5 HT2 receptors; locomotor activity; olanzapine; phencyclidine

Indexed keywords

1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; CLOZAPINE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; HALOPERIDOL; KETANSERIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; OLANZAPINE; PHENCYCLIDINE; RECEPTOR SUBTYPE; RITANSERIN; SEROTONIN 2 ANTAGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 3 ANTAGONIST; SEROTONIN ANTAGONIST;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; HYPERACTIVITY; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHIZOPHRENIA; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BENZODIAZEPINES; CLOZAPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOPERIDOL; MALE; MICE; MOTOR ACTIVITY; PHENCYCLIDINE; PIRENZEPINE; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS;

EID: 0031023562     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050165     Document Type: Article

References (33)

1. Barbeau H, Rossignol S (1991) Initiation and modulation of the locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic and dopaminergic drugs. Brain Res 546:250-260
2. Berry SC, Burton NR, Anis NA, Lodge D (1983) Stereoselective effects of two phencyclidine derivatives on N-methylaspartate excitation of spinal neurones in the cat and rat. Eur J Pharmacol 96:261-267
3. Bowyer JF, Spuhler KP, Weiner N (1984) Effects of phencyclidine. amphetamine, and related compounds on dopamine release from uptake into striatal synaptosomes. J Pharmacol Exp Ther 229:671-680
4. Freed WJ, Bing LA, Wyatt RJ (1984) Effects of neuroleptics on phencyclidine (PCP)-induced locomotor stimulation in mice. Neuropharmacology 23:175-181
5. 3H-catecholamines by rat striatal and hypothalamic synaptosomes. Life Sci 18:1105-1110
6. Hernandez L, Auerbach S, Hoebel BG, (1988) Phencyclidine (PCP) injected in the nucleus accumbens increases extracellular dopamine and serotonin as measured by microdialysis. Life Sci 42:1713-1723
7. Hori T, Suzuki T, Baba A, Abe S, Yamamoto T, Moroji T, Shiraishi H (1996) Effects of phencyclidine metabolites on serotonin uptake in rat brain. Neurosci Lett 209:153-156
8. Jackson DM, Johansson C, Lindgren LM, Benglsson A (1994) Dopamine receptor antagonists block amphetamine and phencyclidine-induced motor stimulation in rats. Pharmacol Biochem Behav 48:465-471
9. 3H-serotonin in rat forebrain. J Neural Transm 53:179-186
10. Johnson KM, Jones SM (1990) Neuropharmacology of phencyclidine: basic mechanisms and therapeutic potential. Annu Rev Pharmacol Toxicol 30:707-750
11. 1C receptors. Br J Pharmacol 94:137-147
12. Kirk RE (1982) Experimental design: procedures for the behavioral sciences, 2nd edn. Brooks/Cole, Belmont, Calif.
13. Lodge D, Anis NA (1982) Effects of phencyclidine on excitatory amino acid activation of spinal interneurones in the cat. Eur J Pharmacol 77:203-204
14. Luby ED, Cohen BO, Rosenbaum G, Gottlieb JS, Kelley R (1959) Study of a new schizophrenimetic drug-Sernyl. Am Med Assoc Arch Neurol Psychiatry 119:61-67
15. Lucki I, Ward HL, Frazer A (1989) Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifluormethylphenyl)piperazine on locomotor activity. J Pharmacol Exp Ther 249:155-164
16. 2A receptors. Eur J Pharmacol 280:R9-R11
17. Meltzer HY (1996) Pre-clinical pharmacology of atypical antipsychotic drugs: a selective review. Br J Psychiatry 168 [suppl 29]: 23-31
18. Meltzer HY, Nash JF (1941) Effects of antipsychotic drugs on serotonin receptors. Pharmacol Rev 43:587-604
19. Moore NA, Calligaro DO, Wong DT, Bymaster F, Tye NC (1993) The pharmacology of olanzapine and other new antipsychotic agents. Curr Opin Invest Drugs 2:281-293
20. 2 receptor mediated behavior in rats. Neurosci Lett 76:335-338
21. Nebeshima T, Ishikawa K, Yamaguchi K, Furukawa H, Kameyama T (1988) Protection with phencyclidine against inactivation of 5-HT2 receptors by sulfhydryl-modifying reagents. Biochem Pharmacol 37:3277-3283
22. Nagano N, Ono H, Fukuda H (1988) Functional significance of subtypes of 5HT receptors in the rat spinal reflex pathway. Gen Pharmacol 19:789-793
23. Nozaki M, Bell JA, Vaupel DB, Martin WR (1977) Responses of the flexor reflex to LSD, tryptamine, 5-hydroxytryptophan, methoxamine and d-amphetamine in acute and chronic spinal rats. Psychopharmacology 55:13-18
24. O'Donnell SR, Wanstall JC (1968) Actions of phencyclidine on the perfused rabbit ear. J Pharmacol 20:125-131
25. Ohno Y, Warnick JE (1989) Presynaptic activation of the spinal serotonergic system in the rat by phencyclidine in vitro. J Pharmacol Exp Ther 250:177-183
26. Schwartz SM, Goldberg MJ, Gidda JS, Cerimele BJ (1994) Effect of zatosetron on ipecac-induced emesis in dogs and healthy men. J Clin Pharmacol 34:250-254
27. 3H] serotonin uptake in synaptosomal preparations from rat brain. Biochem Pharmacol 26:1435-1439
28. Steinpreis RE (1996) The behavioral and neurochemical effects of phencyclidine in humans and animals: some implications for modeling psychosis. Behav Brain Res 74:45-55
29. Tonge SR, Leonard BE (1970) The effects of some hallucinogenic drugs on the amino acid precursors of brain monoamines. Life Sci 9:1327-1335
30. Tonge SR, Leonard BE (1972) Interactions of phencyclidine with drugs affecting noradrenaline metabolism in the rat brain. Psychopharmacology 23:86-90
31. Vaupel DB, Risner ME, Shannon HE (1986) Pharmacologic and reinforcing properties of phencyclidine and the enantiomers of N-allylnormetazocine in the dog. Drug Alcohol Depend 18:173-194
32. Vickroy TW, Johnson KM (1982) Similar dopamine-releasing effects of phencyclidine and nonamphetamine stimulants in striatal slice. J Pharmacol Exp Ther 223:669-674
33. 2 receptors in reserpinized rats. Neuropharmacology 26:1489-1497