Synthesis and affinities for dopamine (D2) and 5-hydroxytryptamine (5-HT2A) receptors of 1-(benzoylpropyl)-4-(1-oxocycloalkyl-2-ethyl)-piperazines as cyclic butyrophenone derivatives

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 3, 1996, Pages 534-541

  Raviña, Enrique ^a   Fueyo, Javier ^a   Masaguer, Christian F ^a   Negreira, Jesús ^a   Cid, Jose ^a   Loza, Isabel ^a   Honrubia, Angeles ^a   Tristán, Helena ^a   Ferreiro, Tomas G ^a   Fontenla, José A ^a   Rosa, Elizabeth ^a   Calleja, José M ^a   De Ceballos, Maria L ^b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b INSTITUTO CAJAL   (Spain)

Author keywords

5 HT2A receptor; Benzocycloalkanone; Butyrophenone pharmacophore; Piperazine derivative, D2 receptor; Thienocycloalkanone

Indexed keywords

1 [3 (4 FLUOROBENZOYL)PROPYL] 4 [2 (4 OXO 4H 5,6 DIHYDROCYCLOPENTA[B]THIOPHEN 5 YL)ETHYL]PIPERAZINE; BUTYROPHENONE DERIVATIVE; DOPAMINE 2 RECEPTOR; PIPERAZINE DERIVATIVE; QF 0506B; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EXTRAPYRAMIDAL SYMPTOM; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ANIMALS; ANTIPSYCHOTIC AGENTS; AORTA, THORACIC; BUTYROPHENONES; DOPAMINE AGENTS; MALE; MUSCLE, SMOOTH, VASCULAR; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; SEROTONIN AGENTS;

EID: 0029989582     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.534     Document Type: Article

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