Serotonin 5-HT(2A) receptors are expressed on pyramidal cells and interneurons in the rat cortex

Synapse

Volumn 27, Issue 1, 1997, Pages 79-82

  Willins, David L ^a   Deutch, Ariel Y ^b   Roth, Bryan L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Antibody; Confocal; Fluorescence; Immunohistochemistry; Microscopy; Parvalbumin

Indexed keywords

SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; BRAIN CORTEX; CELLULAR DISTRIBUTION; DRUG RECEPTOR BINDING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; INTERNEURON; LIGAND BINDING; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; TISSUE DISTRIBUTION; ANIMAL; MALE; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; CEREBRAL CORTEX; IMMUNOHISTOCHEMISTRY; INTERNEURONS; MALE; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN;

EID: 0030612257     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199709)27:1<79::AID-SYN8>3.0.CO;2-A     Document Type: Article

References (24)

1. 2 receptor-mediated modulation of GABA neurons in the rat prefrontal cortex. Soc. Neurosci. Abstr., 22:514.10.
2. Aghajanian, G.K. (1994) Electrophysiological studies on the actions of hallucinogenic drugs at 5-HT2 receptors in rat brain. NIDA Res. Monogr., 146:183-202.
3. Araneda, R., and Andrade, R. (1991) 5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience. 40:399-412.
4. Ashby, C.R., Edwards, E., and Wang, R.Y. (1994) Electrophysiological evidence for a functional interaction between 5-HT1A and 5-HT2A receptors in the rat medial prefrontal cortex: An iontophoretic study. Synapse, 17:173-181.
5. Berry, S.A., Shah, M.C., Kahn, N., and Roth, B.L. (1996) Rapid agonist-induced internalization of the 5-hydroxytryptamine2A receptor occurs via the endosome pathway in vitro. Mol. Pharmacol., 50:306-313.
6. Blue, M.E., Yagaloff, K.A., Mamounas, L.A., Hartig, P.R., and Molliver, M.E. (1988) Correspondence between 5-HT2 receptors and serotonergic axons in rat neocortex. Brain Res., 453:315-328.
7. 2A receptor protein in adult rat CNS. Soc. Neurosci. Abst., 22:698.3.
8. DeFelipe, J., and Jones, E.G. (1992) Parvalbumin immunoreactivity reveals layer IV of monkey cerebral cortex as a mosaic of microzones of thalamic afferent terminations. Brain Res., 562:39-47.
9. Fatemi, S.H., Meltzer, H.Y., and Roth, B.L. (1997) Interaction of atypical antipsychotics with non-dopaminergic systems. In: Handbook of Experimental Pharmacology: Antipsychotic Drugs J. Csernansky, ed. Springer, Heidelberg.
10. Fitzgerald, L.W., Deutch, A.Y., Gasic, G., Heinemann, S.F., and Nestler, E.J. (1995) Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs. J. Neurosci., 15:2453-2461.
11. Foehring, R.C. (1996) Serotonin-modulates - and P-type calcium currents in neocortical pyramidal neurons via a membrane-delimited pathway. J. Neurophysiol., 75:648-659.
12. Garlow, S.J., Morilak, D.A., Dean, R.R., Roth, B.L., and Ciaranello. R.D. (1993) Production and characterization of a specific 5-HT2 receptor antibody. Brain Res., 615:113-120.
13. 2 agonists or antagonists? Neuropsychopharmacology, 3:509-517.
14. 2A receptor in rat cerebral cortex by immunohistochemistry. Soc. Neurosci. Abst., 22:698.2.
15. Marek, G.J., and Aghajanian, G.K. (1996) Serotonergic amplification of apically-derived EPSPs in neocortical pyramidal cells via a persistent sodium current. Soc. Neurosci. Abstr., 22:525.9.
16. Mengod, G., Pompeiano, M., Martinez-Mir, M.I., and Palacios, J.M. (1990) Localization of the mRNA for the 5-HT2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites. Brain Res., 524:139-143.
17. 2 receptors in rat brain. Neuroscience, 54:701-717.
18. Morilak, D.A., Somogyi, P., Lujan-Miras, R., and Ciaranello RD (1994) Neurons expressing 5-HT2 receptors in the rat brain: Neurochemical identification of cell types by immunocytochemistry. Neuropsychopharmacology, 11:157-166.
19. Roth, B.L. (1994) Multiple serotonin receptors: Clinical and experimental aspects. Ann. Clin. Psychiatry, 6:67-78.
20. Roth, B.L., McLean, S., Zhu, X.Z., and Chuang, D.M. (1987) Characterization of two [3H]ketanserin recognition sites in rat striatum. J. Neurochem., 49:1833-1838.
21. 2A) receptor desensitization can occur without down-regulation. J. Pharmacol. Exp. Therap., 275:1638-1646.
22. Seguela, P., Watkins, K.C., and Descarries, L. (1989) Ultrastructural relationships of serotonin axon terminals in the cerebral cortex of the adult rat. J. Comp. Neurol., 289:129-142.
23. Smiley, J.F, and Goldman-Rakic, P.S. (1996) Serotonergic axons in monkey prefrontal cortex synapse predominantly on interneurons as demonstrated by serial electron microscopy. J. Comp. Neurol., 367:431-443.
24. Wright, D.E., Seroogy, K.B., Lundgren, K.H., Davis, B.M., and Jennes, L. (1995) Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain. J. Comp. Neurol., 351:357-373.