RS-127445: A selective, high affinity, orally bioavailable 5-HT(2B) receptor antagonist

British Journal of Pharmacology

Volumn 127, Issue 5, 1999, Pages 1075-1082

  Bonhaus, Douglas W ^a,b   Flippin, Lee A ^a   Greenhouse, Robert J ^a   Jaime, Saul ^a   Rocha, Cindy ^a   Dawson, Mark ^a   Van Natta, Kristine ^a   Chang, L K ^a   Pulido Rios, Tess ^a   Webber, Andrea ^a   Leung, Edward ^a,c   Eglen, Richard M ^a   Martin, Graeme R ^a  

^a Center for Biological Research   (United States)

^b ROCHE BIOSCIENCE   (United States)

^c Medco Research Inc   (United States)

Author keywords

5 HT; 5 HT(2B); Receptor; RS 127445; Serotonin

Indexed keywords

CALCIUM ION; RS 127445; SEROTONIN 2 ANTAGONIST; SEROTONIN 2B RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; JUGULAR VEIN; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STOMACH FUNDUS;

ANIMALS; CALCIUM; CHO CELLS; CRICETINAE; HUMANS; MALE; MUSCLE CONTRACTION; PYRIMIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; VASODILATION;

EID: 0032772062     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702632     Document Type: Article

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