Multiple serotonin receptors: Too many, not enough, or just the right number?

Neuroscience and Biobehavioral Reviews

Volumn 21, Issue 5, 1997, Pages 679-698

  Uphouse, Lynda ^a  

^a TEXAS WOMAN'S UNIVERSITY   (United States)

Author keywords

Behavior; Female reproduction; Glucocorticoids; Receptor interaction; Second messengers

Indexed keywords

SEROTONIN RECEPTOR;

ANIMAL CELL; ARTICLE; BEHAVIOR; CENTRAL NERVOUS SYSTEM; DESENSITIZATION; MEMBRANE BINDING; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; REPRODUCTION; SECOND MESSENGER; SEROTONIN RELEASE; SIGNAL TRANSDUCTION;

ANIMALS; FEMALE; HUMANS; ION CHANNEL GATING; MALE; RECEPTORS, SEROTONIN;

EID: 0030664612     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0149-7634(96)00022-X     Document Type: Article

References (273)

1. Adell A., Artigas F. Differential effects of clomipramine given locally or systematically on extracellular 5-hydroxytyptamine in raphe nuclei and frontal cortex. An in vivo brain microdialysis study. Naunyn-Schmied. Arch. Pharmacol. 343:1991;261-264.
2. Adell A., Carceller A., Artigas F. In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nucleus of the rat: effects of 8-hydroxy-2-(di-n-propylamino)tetralin. J. Neurochem. 60:1993;1673-1681.
3. 1F receptor to multiple signal transduction pathways. Naunyn-Schmied. Arch. Pharmacol. 348:1993;566-575.
4. Akiyoshi J., Hough C., Chuang D.-M. Paradoxical increase of 5-hydroxytryptamine 2 receptors and 5-hydroxytryptamine 2 receptor mRNA in cerebellar granule cells after persistent 5-hydroxytryptamine 2 receptor stimulation. Mol. Pharmacol. 43:1993;349-355.
5. 1A receptors in the rat hippocampus and cortex. Drug Dev. Res. 26:1992;275-286.
6. 4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus. J. Pharmacol. Expl Ther. 257:1991;930-937.
7. Andrade R., Nicoll R.A. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J. Physiol. 394:1987;99-124.
8. 4 receptor desentisation in colliculi neurones. Mol. Pharmacol. 42:1992;808-816.
9. 2 receptors of the rat. Neuropharmacology. 1:1992;1-8.
10. 1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience. 40:1991;399-412.
11. Arendash G.W., Gallo R.V. Serotonin involvement in the inhibition of episodic luteinizing hormone release during electrical stimulation of the midbrain dorsal raphe nucleus in ovariectomized rats. Endocrinology. 102:1978;1199.
12. 2 agonist DOI. Eur. J. Pharmacol. 161:1989;45-51.
13. 2 receptor affinity and also is influenced by other transmitters. Acta Pharmacol. Toxicol. 55:1984;363-372.
14. 2A receptors in the rat medial prefrontal cortex: an iontophoretic study. Synapse. 7:1994;173-181.
15. 1A receptors. Br. J. Pharmacol. 100:1990;793-799.
16. 1 agonists in the rat. Neuroendocrinology. 50:1989;241-247.
17. 2C) receptors reveal novel inverse agonist activity of receptor ligands. J. Biol. Chem. 269:1994;11687-11690.
18. 3 receptors mediate inhibition of acetylcholine release in cortical tissue. Nature. 338:1989;762-763.
19. 2 receptor sensitivity in the rat. Eur. J. Pharmacol. 23:1993;395-406.
20. Baumgold J. Muscarinic receptor-mediated stimulation of adenylyl cyclase. Trends Pharmacol. Sci. 13:1992;339-340.
21. Bedard P., Pycock C.J. "Wet-dog" - shake behaviour in the rat: a possible quantitative model of central 5-hydroxytryptamine activity. Neuropharmacology. 16:1977;663-670.
22. 3H-]8-OH-DPAT and increases the effect of raphe stimulation on 5-HT metabolism. Eur. J. Pharmacol. 178:1990;179-187.
23. Berendsen H.H.G., Broekkamp C.L.E. Behavioural evidence for functional interaction between 5-HT receptor subtypes in rats and mice. Br. J. Pharmacol. 101:1990;667-673.
24. Berg K.A., Clark W.P., Chen Y., Ebersole B.J., McKay R.D.G., Maayani S. 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. Mol. Pharmacol. 45:1994;826-836.
25. Birnbaumer L. Receptor-to-effector signalling through G proteins: roles for βγ dimers as well as α subunits. Cell. 71:1992;1069-1072.
26. Birnbaumer L., Abramowitz J., Brown A.M. Receptor-effector coupling by G proteins. Biochim. Biophys. Acta. 1031:1990;163-246.
27. Blackburn T.P., Cox B., Heapy C.G., Lee T.F., Middlemiss D.N. Supersensitivity of nigra serotonin receptors and rat rotational behaviour. Eur. J. Pharmacol. 71:1981;343-346.
28. 2 binding site after chronic administration of agonists and antagonists. Neuropharmacology. 24:1986;1267-1271.
29. 1A agonist gepirone: electrophysiological, studies in the rat brain. Synapse. 1:1987;470-480.
30. 1A receptors negatively coupled with adenylate cyclase in hippocampal neurons. Naunyn-Schmied. Arch. Pharmacol. 335:1987;588-592.
31. 4 receptor: a place in the sun. Trends Pharmacol. Sci. 13:1992;141-145.
32. 1A receptors: variations in intrinsic activity in transfected HeLa cells. Naunyn-Schmied. Arch. Pharmacol. 345:1992;257-263.
33. 3 receptor. J. Neurochem. 64:1995;1401-1405.
34. 3 binding sites in the rat cerebral cortex and NG 108-15 clonal cells. Biochem. Pharmacol. 40:1990;1541-1550.
35. Bosker F., Klompmakers K., Westenberg H. Extracellular 5-hydroxytryptamine in median raphe nucleus of the conscious rat is decreased by nanomolar concentrations and 8-hydroxy-2-(di-n-propylamin)tetralin and is sensitive to tetrodotoxin. J. Neurochem. 63:1994;2165-2171.
36. Boyson S.J., Alexander A. Net production of cerebrospinal fluid is decreased by SCH-23390. Ann. Neurol. 26:1990;631-635.
37. 1D recognition sites in the human substantia nigra identified with a new iodinated radioligand. Eur. J. Pharmacol. 202:1991;89-91.
38. Buckholtz S., Zhou D., Freedman D.X. Serotonin-2 agonist administration downregulates rat brain serotonin-2 receptors. Life Sci. 42:1988;2439-2445.
39. 1A receptor mRNA expression. J. Neurosci. 13:1993;914-923.
40. 1A binding in rat brain: a combined in situ hybridization/in vitro receptor autoradiography study. Brain Res. 561:1991;51-60.
41. 2A receptor-mediated behavioural responses in obese Zucker rats. Pharmacol. Biochem. Behav. 40:1995;309-312.
42. Chaput Y., Araneda R.C., Andrade R. Pharmacological and functional analysis of a novel serotonin receptor in the rat hippocampus. Eur. J. Pharmacol. 182:1990;441-456.
43. 2) receptor binding sites in cerebellar granule neurons: involvement of calcium influx and a calmodulin-dependent pathway. J. Pharmacol. Expl. Ther. 275:1995;674-680.
44. Clarke W.P., DeVivo M., Beck S.G., Maayani S., Goldfarb J. Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate. Brain Res. 410:1987;3357-3361.
45. Cohen I.R., Wise P.M. Age-related changes in the diurnal rhythm of serotonin turnover in microdissected brain areas of estradiol-treated ovadectomized rats. Endocrinology. 122:1988;2626-2633.
46. Colino A., Hallivell J.V. Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin. Nature. 328:1987;73-77.
47. 2 antagonists inhibit serotonin-stimulated phosphatidylinositol metabolism in cerebral cortex. Neuropharmacology. 23:1984;993-996.
48. Cornfield, L.J.; Nelson, D.L. Biochemistry of 5-hydroxytryptamine receptor subtypes: coupling to second messenger systems. In: Peroutka, S.J., ed. Serotonin receptor subtypes. Basic and clinical aspects. New York: Wiley-Liss; 1991:81-102.
49. Crino P.B., Vogt B.A., Volicer L., Wiley R.G. Cellular localization of serotonin 1A, 1B and uptake sites in cingulate cortex of the rat. J. Pharmacol. Expl Ther. 252:1990;651-656.
50. Culman J., Kvetnannsky R., Torda T., Murgas K. Serotonin concentration in individual hypothalamic nuclei of rats exposed to acute immobilization stress. Neuroscience. 5:1980;1503-1506.
51. Darmani N.A., Gerdes C.F. Temporal differential adaptation of head-twitch and ear-scratch responses following administration of challenge doses of DOI. Pharmacol. Biochem. Behav. 49:1995;545-550.
52. 2 receptor-induced head-twitch behaviour in mice. Eur. J. Pharmacol. 186:1990;115-118.
53. Darmani N.K., Martin B.R., Glennon R.A. Behavioral evidence for differential adaptation of the serotonergic system following acute and chronic treatment with (±)-1 -(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) or ketanserin. Pharmacol. Expl Ther. 262:1992;692-698.
54. 2 receptors. Pharmacol. Biochem. Behav. 36:1990;901-906.
55. Davies F.M., Deisz R.A., Prince D.A., Peroutka S.J. Two distinct effects of 5-hydroxytryptamine on single cortical neurons. Brain Res. 423:1987;347-352.
56. DeVivo M., Maayani S. Inhibition of forskolin stimulated adenylate cyclase activity by 5-HT receptor agonists. Eur. J. Pharmacol. 119:1985;231-258.
57. Dickinson S.L., Kennett G.A., Curzon G. Reduced 5-hydroxytryptamine-dependent behaviour in rats following chronic corticosterone treatment. Brain Res. 345:1985;10-17.
58. Dillon-Carter O., Chuang D.-M. Homologous desensitization of muscarinic, cholinergic, histaminergic, adrenergic and serotonergic receptors coupled to phospholipase C in cerebellar granule cells. J. Neurochem. 51:1989;598-603.
59. 1 binding sites as target for novel putative anxiolytics. Naunyn-Schmied. Arch. Pharmacol. 328:1985;883-892.
60. 1B receptor in serotoninergic neurons of anterior raphe nuclei in the rat brain. Synapse. 19:1995;18-27.
61. 2 receptor mechanism plays a key role in the proestrous surge of luteinizing hormone in the rat. Psychoneuroendocrinology. 19:1994;95-399.
62. 3 R-A subunit expressed in Xenopus laevis oocytes. Neuropharmacology. 33:1994;473-482.
63. Dumuis A., Bouhelal R., Sebben M., Cory R., Bockaert J. A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Mol. Pharmacol. 32:1988;880-887.
64. Dunn J.D., Orr S.E. Differential plasma corticosterone responses to hippocampal stimulation. Expl Brain Res. 54:1984;1-6.
65. 2 receptor agonist on phosphoinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. 31:1992;615-621.
66. Edwards E., Kornrich W., Houtten P.V., Henn F.A. Presynaptic serotonin mechanisms in rats subjected to inescapable shock. Neuropharmacology. 31:1992;323-330.
67. 2 receptor sensitivity after continuous gepirone treatment. Eur. J. Pharmacol. 111:1985;389-392.
68. Elliott J.M., Flanigan T.P., Newberry N.R., Zetterstom T., Leslie R.A. 5-HT receptor subtypes: aspects of their regulation and function. Neurochem. Intl. 25:1994;537-543.
69. 3 receptor-A mRNA in NG108-15 cells. J. Neurochem. 66:1995;1917-1925.
70. 1B binding sites. Naunyn-Schmied. Arch. Pharmacol. 332:1986;1-7.
71. Erlander M.G., Lovenberg T.W., Baron B.M., Delecea L., Danielson P.E., Racke M., Slone A.L., Siegel B.W., Foye P.E., Cannon K., Bruns J.E., Sutcliffe J.C. Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain. Proc. Natl. Acad. Sci. USA. 90:1993;3452-3456.
72. Esbenshade T.A., Minneman K.P. Adrenergic receptor subtypes: pharmacological approaches. Neuroprotocols. 4:1994;2-13.
73. + current in colliculi neurons via activation of a cyclic AMP-dependent protein kinase. Br. J. Pharmacol. 105:1992;973-979.
74. 1A receptor binding sites following chronic treatment with ipsapirone measured by quantitative autoradiography. Synapse. 12:1992;75-81.
75. i protein. Cell Signal. 3:1991;547-557.
76. Felder C.C., Kanterman R.Y., Ma A.L., Axelrod J. Serotonin stimulates phospholipase A2 and release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositol-phospholipid hydrolysis. Proc. Natl. Acad. Sci. USA. 87:1990;2187-2191.
77. Feldman S., Weidenfeld J., Conforti W., Saphier D. Differential recovery of adrenocortical response to neural stimuli following administration of 5,7-dihydroxytryptamine into the hypothalamus. Expl Brain Res. 85:1991;144-148.
78. Feurstein T.J., Hertting G. Serotonin enhances noradrenaline release: evidence for facilitatory 5-HT receptors within the CNS. Naunyn-Schmied. Arch. Pharmacol. 333:1986;191-197.
79. 1A receptor antagonists: utility as research tools and therapeutic agents. Trends Pharmacol. Sci. 14:1993;442-448.
80. 1B) agonists in the isolation-induced social behavioural deficit test. Neuropharmacology. 30:1991;623-627.
81. Frankfurt M., McKittrick C.R., Mendelson S.D., McEwen B.S. Effect of 5,7-dihydroxytryptamine, ovariectomy and gonadal steroids on serotonin receptor binding in rat brain. Neuroendocrinology. 59:1994;245-250.
82. Frankfurt M., Mendelson S.D., McKittrick C.R., McEwen B.S. Alterations of serotonin receptor binding in the hypothalamus following acute denervation. Brain Res. 601:1993;349-352.
83. 1A-mediated responses: effect of treatments that modify serotonergic neurotransmission. Ann. NY Acad Sci. 600:1990;460-475.
84. Fuxe, K.; Agnati, L.F. (eds). Volume transmission in the brain. New York: Raven Press; 1991.
85. Gaddum J.H., Picarelli Z.P. Two kinds of tryptamine receptors. Br. J. Pharmacol. Chemother. 12:1957;323-328.
86. Galzin A.M., Langer S.Z. Modulation of 5-HT release by presynaptic inhibitory and facilitatory 5-HT receptors in brain slices. Adv. Biosci. 83:1991;59-62.
87. Gereau R.W., Kedzie K.A., Renner K.J. Effect of progesterone on serotonin turnover in rats primed with estrogen implants into the ventromedial hypothalamus. Brain Res. Bull. 32:1993;293-300.
88. Gobbi M., Cavanus S., Miari A., Mennini T. Effect of acute and chronic administration of buspirone on serotonin and benzodiazepine receptor subtypes in the rat brain: an autoradiographic study. Neuropharmacology. 30:1991;313-321.
89. 1B binding sites in rat brain membranes. Evidence for guanine nucleotide regulation of agonist affinity states. J. Pharmaol. Expl Ther. 243:1987;989-1001.
90. 2+ permeability of cloned and native 5-hydroxytryptamine type 3 receptors. Mol. Pharmacol. 45:1994;1120-1128.
91. Hen R. Of mice and flies: commonalities among 5-HT receptors. Trends Pharmacol. Sci. 13:1992;160-165.
92. 1A receptor agonists on luteinizing hormone-releasing hormone release from cultured fetal rat hypothalamic cells: interactions with progesterone. Neuroendocrinology. 61:1995;11-18.
93. Hery M., Laplante K., Kordon C. Participation of serotonin in the phasic release of luteinizing hormone. II. Effect of lesions of serotonin-containing pathways in the central nervous system Endocrinology. 102:1978;1019-1025.
94. 3]5-HT binding site subtype in bovine brain membranes. J. Neurosci. 7:1987;894-903.
95. Hjorth S., Suchowski C.S., Galloway M.P. Evidence for 5-HT autoreceptor-mediated, nerve impulse-independent, control of 5-HT synthesis in the rat brain. Synapse. 19:1995;170-176.
96. Hoffman, G.E.; Lee, W.-S.; Wray, S. Gonadotropin releasing hormone (GnRH). In: Nemeroff, C., ed. Neuroendocrinology. Boca Raton; CRC Press; 1992:185-218.
97. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.A. VII International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:1994;56-224.
98. 3H]ketanserin. Eur. J. Pharmacol. 118:1985;13-23.
99. Hoyer D., Middlemiss D.N. Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain. Trends Pharmacol. Sci. 10:1989;131-132.
100. 2 recognition sites Brain Res. 376:1986;97-107.
101. Hoyer D., Schoeffter P. 5-HT receptors: subtypes and second messengers. J. Recept. Res. 11:1991;197-214.
102. Hunter T. Protein kinases and phosphatases: the Yin and Yang of protein phosphorylation and signalling. Cell. 81:1995;225-236.
103. Jackson, M.B. Activation of receptors coupled to G-proteins and protein kinase. In: Jackson, M.B., ed. Thermodynamics of membrane receptors and channels. Massachusetts: CRC Press; 1993:295-326.
104. 1A agonist, 8-OH-DPAT, on lordosis behavior. Horm. Behav. 30:1996;145-152.
105. s-stimulated adenylyl cyclases by phorbol ester treatment. J. Biol. Chem. 268:1993;3829-3832.
106. Jacobs B.L., Azmitia E.C. Structure and function of the brain serotonin system. Physiol. Rev. 74:1992;165-229.
107. Jacobs B.L., Fornal C.A. Activity of brain serotonergic neurons in the behaving animal. Pharmacol. Rev. 41:1991;563-578.
108. Jacobs B.L., Fornal C.A. 5-HT and motor control: a hypothesis. Trends Neurosci. 16:1993;346-351.
109. James M.D., Hole D.R., Wilson C.A. Differential involvement of 5-hydroxytryptamine (5-HT) in specific hypothalamic areas in the mediation of steroid induced changes in gonadotropin release and sexual behaviour in female rats. Neuroendocrinology. 49:1989;561-569.
110. Jennes L., Beckman W.C., Stumpf W.E., Garzanna R. Anatomical relationships of serotoninergic and noradrenalinergic projections with the GnRH system in septum and hypothalamus. Expl Brain Res. 46:1982;331-338.
111. Johnson M.D., Crowley W.R. Acute effects of estradiol on circulating luteinizing hormone and prolactin concentrations and on serotonin turnover in individual brain nuclei. Endocrinology. 113:1983;1935-1941.
112. Johnson J.K., Kitts C.S. Serotonergic mediation of a negative feedback effect of estrogen on luteinizing hormone release in ovariectomized rats. Endocrinology. 123:1988;2270-2275.
113. Katada T., Kusakabe K., Oinuma M., Ui M. A novel mechanism for the inhibition of adenylate cyclase via inhibitory GTP-binding proteins. Calmodulin-dependent inhibition of the cyclase catalyst by the βγ-subunits of GTP-binding proteins. J. Biol. Chem. 262:1987;11897-11900.
114. 1A presynaptic but not postsynaptic receptor-mediated responses: Relationship to antidepressant-like action. Eur. J. Pharmacol. 138:1987;52-60.
115. 1A receptor antagonist. Brain Res. 673:1995;217-225.
116. 3 receptors. Naunyn-Schmied. Arch. Pharmacol. 342:1990;22-30.
117. Kiss J., Halasz B. Demonstration of serotoninergic axons terminating on luteinizing hormone releasing hormone neurons in the preoptic area of the rat using a combination of immunocytochemistry and high resolution autoradiography. Neuroscience. 14:1985;71-79.
118. Kitts C.S., Johnson J.H. Reversal by estrogen of the effect of dorsal raphe stimulation on release of LH but not prolactin. J. Neurosci. Res. 15:1986;253-258.
119. Koenig J.I., Gudelsky G.A., Meltzer H.Y. Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur. J. Pharmacol. 137:1987;1-8.
120. Kow L.-M., Mobbs C.V., Pfaff D.W. Roles of second-messenger systems and neuronal activity in the regulation of lordosis by neurotransmitters, neuropeptides and estrogen: a review. Neurosci. Biobehav. Rev. 18:1994;251-268.
121. Kow L.-M., Tsai U.-F., Wang L., Pfaff D.W. Electrophysiological analyses of serotonergic actions on neurons in hypothalamic ventromedial neurons in vitro: receptor subtypes involved and implications for regulation of feeding and lordosis behaviors. Clin. J. Physiol. 35:1992;105-121.
122. 2 receptor-mediated wet-dog shakes. Psychopharmacology. 108:1992;27-32.
123. 2B receptor. Mol. Pharmacol. 46:1994;227-234.
124. 2F) from rat stomach fundus. Mol. Pharmacol. 40:1992;549-557.
125. Labrecque J., Fargin A., Bouvier M., Chidiac P., Dennis M. Serotonergic antagonists differentially inhibit spontaneous activity and decrease ligand binding capacity of the rat 5-hydroxytryptamine type 2C receptor in Sf9 cells. Mol. Pharmacol. 48:1995;150-159.
126. Lakoski, J.M. Cellular electrophysiological approaches to the central regulation of female reproductive aging. In: Lakoski, J.M.; Perez-Polo, J.R.; Rassin, D.K., eds. Neurology and neurobiology, Vol. 50, Neural control of reproductive function. New York: Alan R. Liss, Inc.; 1989:209-243.
127. Lakoski J.M., Aghajanian G.K. Effect of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. 24:1985;265-273.
128. 1A receptor agonist 8-OH-DPAT. Neuropharmacology. 28:1990;88-91.
129. 1A receptor agonists on CRF-induced behavior. Psychopharmacology. 104:1991;132-136.
130. LeCorre S., Segu L., Caldani m., Chemineau P. Differences in ketanserin binding in the ventromedial hypothalamus of ewes responsive or refractory to short days. Neuroendocrinology. 60:1994;589-600.
131. Lesch K.P., Lerer B. The 5-HT receptor-G-protein-effector system complex in depression. I. Effect of glucocorticoids J. Neural Transm. 87:1991;3-18.
132. 3 receptors in the secretion of prolactin, ACTH, and renin. Neuroendocrinology. 58:1993;65-72.
133. Leysen J.E. Problems in in vitro receptor binding studies and identification and role of serotonin receptor sites. Neuropharmacology. 23:1984;247-254.
134. 2 receptors by DOM treatment. Eur. J. Pharmacol. 163:1989;145-149.
135. Leysen J.E., VanGompel P., Commeren W., Woestenborghs R., Janssen P. Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with the serotonin-S2 antagonists: ritanserin and setoperone. Psychopharmacology. 93:1986;434-444.
136. 1A agonists. Neuropharmacology. 31:1992;983-989.
137. Licati F., Vollsi G.L., Maugeri G., Santangelo F. Excitatory and inhibitory effects of 5-hydroxytryptamine on the firing rate of medial vestibular nucleus neurons in the rat. Neurosci. Lett. 154:1993;195-198.
138. Lindvall-Axelsson M., Mathew C., Milsson C., Owman C. Effect of 5-hydroxytryptamine on the rate of cerebrospinal fluid production in rabbit. Expl Neurol. 99:1988;362-368.
139. Liposits Z., Phelix C., Paull W.K. Synaptic interaction of serotonergic axons and corticotropin releasing factor (CRF) synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. A light and electron microscopic immunocytochemical study. Histochemistry. 91:1987;541-549.
140. 2) agonists and antagonists on corticosterone secretion. Neuroendocrinology. 44:1987;305-310.
141. 7) implicated in the regulation of mammalian circadian rhythms. Neuron. 11:1993;449-458.
142. 1 receptors and behavior. Neurosci. Biobehav. Rev. 6:1992;83-93.
143. Luine V.M. Serotonin, catecholamines, and metabolites in discrete brain areas in relation to lordotic responding on proestrus. Neuroendocrinology. 57:1993;946-954.
144. Lynch K.R., Harrison J.K., Pearson W.R. Classification of adrenergic receptor subtypes: molecular biologic approaches. Neuroprotocols. 4:1994;14-19.
145. 2 receptor. In: Sanders-Bush, E., ed. The serotonin receptors. Clifton, NJ: The Humana Press; 1988:59-88.
146. 1B binding sites following 5,7-dihydroxytryptamine axotomy in the adult rat. Brain Res. 623:1993;45-348.
147. 2A antagonist. Eur. J. Pharmacol. 259:1994;137-141.
148. 2A receptor-mediated excitatory effects of serotonin on interneurons in rat pyriform cortex. Synapse. 22:1995;123-140.
149. 3 receptor, a serotonin-gated ion channel. Science. 254:1991;432-437.
150. Martire M., Pistritto G., Preziosi P. Different regulation of serotonin receptors following adrenal hormone imbalance in the rat hippocampus and hypothalamus. J. Neural Transm. 78:1989;109-120.
151. Maswood N., Uphouse L. Effects of female gonadal hormones and DOI on the behavioral response to 8-OH-DPAT. Neuropharmacology. 35:1996;497-501.
152. 1A receptor-mediated inhibition of lordosis behavior. Neuropharmacology, (in press).
153. 5B receptors define a new family of serotonin receptors: Cloning, functional expression, and chromosomal localization. Mol. Pharmacol. 43:1993;313-319.
154. Maura G., Raiteri M. Acetylcholine release from rat hippocampal slices is modulated by 5-HT. Eur. J. Pharmacol. 165:1989;173-179.
155. 6 serotonin receptor in stately transfected 293 cells. Soc. Neurosci. Abstr. 21:1994;477.22.
156. McGonigle, P.; Molinoff, P. Quantitative aspects of drug-receptor interactions. In: Siegel, G.; Agranoff, B.; Albers, R.W.; Molinoff, P., eds. Basic neurochemistry, 4th edn. New York: Raven Press; 1989:183-202.
157. 2 receptors in rat brain. Neuropharmacology. 2:1989;82-92.
158. 4 receptor mediating tachycardia in isolated piglet right atrium. Br. J. Pharmacol. 118:1993;1023-1030.
159. 1A receptor-mediated hypothermia in mice: absence of spare receptors and rapid induction of tolerance. Pharmacol. Biochem. Behav. 43:1992;405-411.
160. Mendelson S.D. A review and reevaluation of the role of serotonin in the modulation of lordosis behavior in the female rat. Neurosci. Biobehav. Rev. 16:1992;309-350.
161. 2 receptors in the dorsal hippocampus of male and female rats. Neuroendocrinology. 54:1991;454-461.
162. 1B receptors in the dorsal hippocampus, and cortex of the rat. Neuroendocrinology. 55:1992;444-450.
163. Meyer D.C., Eadens D.J. The role of endogenous serotonin in phasic LH release. Brain Res. Bull. 15:1985;883-886.
164. Meyer D.C., McRee C., Jacobs M. Role of 5-hydroxytryptamine receptors on luteinizing-hormone-releasing hormone release in the ovariectomized estradiol-treated rat. Brain Res. Bull. 28:1992;853-860.
165. Middlemiss D.N., Neill J., Tricklebank M.D. Subtypes of the 5-HT receptor involved in hypothermia and forepaw treading induced by 8-OH-DPAT. Br. J. Pharmacol. 85:1985;251P.
166. 1C/2 receptors. J. Pharmacol. Expl Ther. 262:1992;451-463.
167. 1B receptors on the sympathetic nerve terminals of the rat inferior vena cava. Naunyn-Schmied. Arch. Pharmacol. 341:1990;391-397.
168. 2+-insensitive adenylyl cyclases in rat brain. Synapse. 14:1993;50-59.
169. Monsma F.J. Jr., Shen Y., Ward R.P., Hamblin M.W., Sibley D.R. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol. Pharmacol. 43:1993;320-327.
170. 2 receptors in the rat brain. Neuroscience. 54:1993;701-717.
171. Munaro N.I. The effects of ovarian steroids on hypothalamic 5-hydroxytryptamine neuronal activity. Neuroendocrinology. 25:1978;270-276.
172. 1A antagonists WAY100135 and SDZ 216-525 on 5-HT neuronal firing in the guinea-pig dorsal raphe nucleus. Neuropharmacology. 33:1994;61-67.
173. Neer E.J. Heterotrimic G proteins: organizers of transmembrane signals. Cell. 80:1995;249-257.
174. 3 receptors in cultured mouse neuroblastoma cells. J. Physiol. 411:1989;759-772.
175. 3 binding sites in rat brain cortical membranes. Biochem. Pharmacol. 38:1989;1693-1695.
176. 1-like receptor mediates a pertussis toxin-sensitive inhibition of rat ventromedial hypothalamic neurons in vitro. Br. J. Pharmacol. 95:1988;6-8.
177. 2 receptors to decrease potassium conductance in rat nucleus accumbens neurons. J. Physiol. 417:1989;1-12.
178. O'Connor J.J., Kruk Z.L. Frequency dependency of 5-HT autoreceptor function in rat dorsal raphe and suprachiasmatic nuclei studied using fast cyclic voltammetry. Brain Res. 568:1991;123-130.
179. O'Dowd, B.F.; Seeman, P.; George, S.R. Dopamine receptors. In: Peroutka, S.J., ed. Handbook of receptors and channels. G protein-coupled receptors. Boca Raton: CRC Press: 1994:95-123.
180. Osman R., Keitz S.A., Goldfarb J., Maayani S. Kinetics of response and drug action. Neuropsychopharmacology. 3:1990;417-425.
181. 1A receptor agonists on hypothalamo-pituitary-adrenal axis activity and corticotropin-releasing factor containing neurons in the rat brain. Eur. J. Pharmacol. 190:1990;113-122.
182. 2 agonist (±)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane stimulates the hypothalamic-pituitary-adrenal (HPA) axis. I. Acute effects on HPA axis activity and corticotropin-releasing factor-containing neurons in the rat brain J. Pharmacol. Expl Ther. 256:1992;787-794.
183. 2 agonist (±)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane stimulates the hypothalamic-pituitary-adrenal (HPA) axis. II. Biochemical and physiological evidence for the development of tolerance after chronic administration J. Pharmacol. Expl Ther. 256:1992;795-800.
184. 1A agonist, on ACTH and PRL secretion in the rat. Neuroendocrinology. 61:1995;159-166.
185. + membrane channels encoded by brain mRNA. Proc. Natl. Acad. Sci. 88:1991;2560-2562.
186. 1b like receptor and antagonism by methiothepin. Neuropharmacology. 33:1994;68-76.
187. Pazos A., Hoyer D., Palacios M.J. The binding of serotonergic ligands to the porcine choroid plexus: characterization of a new type of serotonin recognition site. Eur. J. Pharmacol. 106:1984;539-546.
188. Pazos A., Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors Brain Res. 346:1985;226-340.
189. Pazos A., Probst A., Palacios J.M. Serotonin receptors in the human brain. IV. Autoradiographic mapping of serotonin-2 receptors Neuroscience. 21:1987;123-152.
190. 1C binding sites in rat frontal cortex. J. Neurochem. 46:1986;529-540.
191. Peroutka, S.J. The molecular pharmacology of 5-hydroxytryptamine receptor subtypes. In: Peroutka, S.J., ed. Serotonin receptor subtypes: basic and clinical aspects. New York: Wiley-Liss, Inc.; 1991:65-80.
192. Peroutka, S.J. 5-Hydroxytryptamine receptors. In: Peroutka, S.J., ed. Handbook of receptors and channels, Vol. 1. G protein coupled receptors. Boca Raton: CRC Press; 1994:231-236.
193. Peroutka S.J. 5-Hydroxytryptamine receptors in vertebrates and invertebrates: why are there so many. Neurochem. Intl. 25:1994;533-536.
194. Peroutka S.J., Hamik A., Harrington M.A., Hoffman A.J., Mathis C.A., Pierce P.A., Wang S.S.H. (S)-(-) [77Br]4-bromo-2,5-dimethoxyamphetamine labels a novel 5-HT binding site in brain membranes. Mol. Pharmacol. 34:1988;537-542.
195. 3 receptors. In: King, F.D.; Jones, B.J.; Sanger, G.J., eds. 5-Hydroxytryptamine-3 receptor antagonists. Boca Raton: CRC Press; 1994:123-153.
196. Petruz, P.; Merchenthaler, I. The corticotropin-releasing factor system. In: Nemeroff, C., ed. Neuroendocrinology. Boca Raton: CRC Press; 1992:129-184.
197. Pfaff, D.W.; Modianos, D. Neural mechanisms of female reproductive behavior. In: Adler, N.; Pfaff, D.; Goy, R.W., eds. Handbook of behavioral neurobiology. New York: Plenum Press; 1985:423-493.
198. Pfaff D.W., Sakuma Y. Facilitation of the lordosis reflex of female rats from the ventromedial nucleus of the hypothalamus. J. Physiol. 288:1979;189-202.
199. Pierce P.A., Peroutka S.J. D-Lysergic acid diethylamide differentially affects the dual actions of 5-hydroxytryptamine on cortical neurons. Neuropharmacology. 29:1990;705-712.
200. s-stimulated adenylyl cyclases. Curr. Opin. Neurobiol. 3:1993;345-351.
201. Pin J.-P., Duvoisin R. Review: neurotransmitter receptors. I. The metabotropic glutamate receptors: structure and function Neuropharmacology. 34:1995;1-26.
202. 1D receptors regulate 5-HT release in the rat raphe nuclei. In vivo voltammetry and in vitro superfusion studies. Neuropsychopharmacology. 13:1995;249-260.
203. Pinto W., Battaglia G. Comparative recovery kinetics of 5-hydroxytryptamine 1A, 1B and 2A receptor subtypes in rat cortex after receptor inactivation: evidence for differences in receptor production and degradation. Mol. Pharmacol. 46:1994;1111-1119.
204. Plassat J.L., Amlaiky N., Hen R. Molecular cloning of a mammalian serotonin receptor that activates adenylyl cyclase. Mol. Pharmacol. 44:1993;229-236.
205. Pritchett D.B., Bach A.W.J., Wozny M., Taleb O., Dal Toso R., Shih J.C., Seeburg P.H. Structure and functional expression of cloned rat serotonin 5-HT-2 receptor. EMBO J. 7:1988;4135-4140.
206. Przegalinski E., Ismaiel A.M., Chojnacka-Wojcik E., Budziszewska B., Tatarczynska E., Blaszczynska E. The behavioural, but not the hypothermic or corticosterone, response to 8-hydroxy-2-(di-n-propylamino)tetralin, is antagonized by NAN-190 in the rat. Neuropharmacology. 29:1990;521-526.
207. 1A receptor. J. Biol. Chem. 266:1991;14747-14753.
208. 3 receptors. New York: Academic Press; 1992:129-156.
209. Renner K.J., Allen D.L., Luine V.N. Monoamine levels and turnover in brain: relationship to priming actions of estrogen. Brain Res. Bull. 16:1986;469-475.
210. 4 receptor. Naunyn-Schmied. Arch. Pharmacol. 346:1992;496-503.
211. 2 receptors in mouse brain. Mol. Pharmacol. 43:1993;84-89.
212. 4 receptors in rat esophagus: functional and second messenger studies. J. Pharmacol. Expl Ther. 272:1995;977-983.
213. 1A receptor antagonist WAY100135: an in vivo microdialysis study. Eur. J. Pharmacol. 239:1993;195-202.
214. 7) activating cAMP formation. Proc. natn. Acad. Sci. 96:1993;8547-8551.
215. Ruffolo R. Important concepts of receptor theory. J. Auton. Pharmacol. 2:1982;277-295.
216. 1A agonist, 8-OH-DPAT. Pharmacol. Biochem. Behav. 43:1992;953-955.
217. 1C receptor reserve in choroid plexus masks receptor subsensitivity. J. Pharmacol. Expl Ther. 252:1990;984-988.
218. Sandou F., Hen R. 5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates. Neurochem. Ant. 25:1994;503-532.
219. 3 antagonists. Psychoneuroendocrinology. 20:1995;2399-2457.
220. Saphier D., Feldman S. Paraventricular nucleus neuronal responses following electrical stimulation of the midbrain dorsal raphe: evidence for cotransmission. Expl Brain Res. 78:1989;407-414.
221. 1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, of antidromically identified paraventricular nucleus neurons in the rat. Brain Res. 615:1993;7-12.
222. Sapolsky R.M., Krey L.C., McEwen B.S. Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response. Proc. Natl. Acad. Sci. 81:1984;6174-6177.
223. Sarri E., Picatoste F., Claro E. Neurotransmitter-specific profiles of inositol phosphates in rat brain cortex: relation to the mode of receptor activation of phosphoinositide, phospholipase C. J. Pharmacol. Expl Ther. 272:1995;77-84.
224. Sawchenko P.E. Evidence for a local site of action of glucocorticoids in inhibiting CRF and vasopressin expression in the paraventricular nucleus. Brain Res. 403:1987;213-245.
225. Sawchenko P.E., Swanson L.E., Steinbush H.W.M., Verhofstad A.A.J. The distribution and cells of origin of serotonergic inputs to the paraventricular nuclei of the rat. Brain Res. 272:1983;355-360.
226. Schechter L.E., Bolanos F.J., Gozlan H., Lanfumey L., Haj-Dahmane S., Laporte A.M., Fattaccini C.M., Hamon M. Alterations of central serotonergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies. J. Pharmacol. Expl Ther. 255:1990;1335-1347.
227. Seckl J.R., Fink G. Use of in situ hybridization to investigate the regulation of hippocampal corticosterone receptors by monoamines. J. Steroid Biochem. Mol. Biol. 40:1991;685-688.
228. Sharp T., Bramwell S.R., Clark D., Grahame-Smith D.G. In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis; changes in relation to 5-hydroxytryptaminergic neuronal activity. J. Neurochem. 53:1989;234-240.
229. 1C receptors in pyramidal cells and 5-HT receptors in interneurons. Synapse. 9:1991;230-248.
230. 7 serotonin receptor subtype. J. Biol. Chem. 23:1993;18200-18204.
231. Shimizu A., Take S., Hori T., Oomura Y. In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis: significant enhancement by immobilization stress in rats. Brain Res. Bull. 28:1992;727-734.
232. 7 serotonin receptors: molecular biology and pharmacology. Neurotransmissions. XI:1995;1-6.
233. 7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatment. Mol. Pharmacol. 47:1995;99-103.
234. 1B agonists. Synapse. 1:1987;3-9.
235. Starkey S.J., Skingle M. Effects of WAY-100135, 8-OH-DPAT, and sumatriptan on 5-HT release evoked by a single electrical pulse in slices of guinea-pig dorsal raphe nucleus. Br. J. Pharmacol. 108:1993;100P.
236. Steinbusch, H.W.M. Serotonin-immunoreactive neurons and their projections in the CNS. In: Bjorklund, K.; Hokfelt, T., eds. Handbook of chemical neuroanatomy, Vol. 3. Classical transmitters and transmitter receptors in the CNS, part II. New York: Elsevier; 1984; 70-125.
237. Sumner B.E.K., Fink G. Effects of acute estradiol on 5-hydroxytryptamine and dopamine receptor subtype mRNA expression in female rat brain. Mol. Cell. Neurosci. 4:1993;83-92.
238. Swanson L.W., Sawchenko P.E., Rivier J., Vale W.S. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology. 35:1983;182-186.
239. Tan H., Miletic V. Diverse actions of 5-hydroxytryptamine on frog spinal dorsal horn neurons in vitro. Neuroscience. 49:1992;913-923.
240. Tang W.-J., Gilman A.G. Type-specific regulation of adenylyl cyclase by G protein βγ subunits. Science. 254:1991;1500-1503.
241. Tang W.-J., Krupinski J., Gilman A.G. Expression and characterization of calmodulin-activated (Type I) adenylate cyclase. J. Biol. Chem. 266:1991;8595-8603.
242. 2 receptor binding sites. Drug Dev. Res. 24:1991;93-105.
243. Teitler M., Herrick-Davis K. Multiple serotonin receptor subtypes: molecular cloning and functional expression. Crit. Rev. Neurobiol. 8:1994;175-188.
244. Torres G.E., Chaput Y., Andrade R. Cyclic AMP and protein kinase A mediate 5-hydroxytryptamine type 4 receptor regulation of calcium-activated potassium current in adult hippocampal neurons. Mol. Pharmacol. 47:1995;191-218.
245. 1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. Eur. J. Pharmacol. 106:1984;271-282.
246. 1 receptor agonist, RU 24969, in the rat. Neuropharmacology. 25:1986;877-886.
247. Unsworth C.D., Molinoff P.B. Characterization of a 5-hydroxytryptamine receptor in mouse neuroblastoma N18TG2 cells. J. Pharmacol. Expl Ther. 269:1994;246-255.
248. 1A agonist, 8-OH-DPAT, on lordosis behavior. Pharmacol. Biochem. Behav. 47:1994;467-470.
249. 1A agonist in the VMN. Brain Res. 637:1994;173-180.
250. 1A partial agonist/antagonist, NAN-190, on female sexual behavior. Neuropharmacology. 31:1992;969-981.
251. Uphouse L., Colon L., Cox A., Caldarola-Pastuszka M., Wolf A. Effects of mianserin and ketanserin on lordosis behavior after systemic treatment or infusion into the ventromedial nucleus of the hypothalamus. Brain Res. 718:1996;46-52.
252. 1A agonist, 8-OH-DPAT, on sexual behaviors of the proestrous rat. Pharmacol. Biochem. Behav. 39:1991;635-640.
253. Van de Kar L.D. Neuroendocrine pharmacology of serotonergic (5-HT) neurons. Ann. Rev. Pharmacol. Toxicol. 31:1991;289-310.
254. 2 antagonist on prolactin secretion. Neuropharmacology. 28:1989;299-305.
255. 1A receptor ligands on rat dorso-lateral septal neurones in vitro. Br. J. Pharmacol. 196:1991;893-899.
256. Van Wijngaarden I., Tulp M.T., Soudijn W. The concept of selectivity in 5-HT receptor research. Eur. J. Pharmacol. 188:1990;301-312.
257. 1A subtype. Eur. J. Pharmacol. 113:1985;463-464.
258. 1A receptors to adenylyl cyclase. Mol. Pharmacol. 41:1992;999-1007.
259. Waeber C., Schoeffter P., Hoyer D., Palacious J.M. The serotonin-1D receptor: a progress review. Neurochem. Res. 15:1990;567-582.
260. Walker R.F., Wilson C.A. Changes in hypothalamic serotonin associated with amplification of LH surges by progesterone in rats. Neuroendocrinology. 37:1983;221-226.
261. 1 receptors mediate inhibition of cyclic AMP production in neurons. Eur. J. Pharmacol. 129:1986;227-253.
262. 1A receptors inhibit adrenocortical secretion. Neuroendocrinology. 56:1993;272-281.
263. Wilkinson, L.O.; Dourish, C.T. Serotonin and animal behaviour. In: Peroutka, S., ed. Serotonin receptor subtypes; basic and clinical aspects. New York: John Wiley and Sons, Ltd; 1991:147-210.
264. Williams J.T., Colmers W.F., Pan A.A. Voltage- and ligand-activated inwardly rectifying currents in dorsal raphe neurons in vitro. J. Neurosci. 8:1988;3499-3506.
265. 2 agonist, DOI, on female lordosis behavior (submitted).
266. Wright D.E., Jennes L. Lack of expression of serotonin receptor subtype 1A, 1C and 2 mRNAs in gonadotropin releasing hormone producing neurons of the rat. Neurosci. Lett. 163:1993;1-4.
267. Xia Z., Refsdal C.D., Merchant K.M., Dorsa D.M., Storm D.R. Distribution of mRNA for the calmodulin-sensitive adenylate cyglase in rat brain: expression in areas associated with learning and memory. Neuron. 5:1991;431-443.
268. 3 receptors. New York: Academic Press; 1992:103-128.
269. 2 receptors in the wetdog shake behavior induced by 5-hydroxytryptophan in the rat. Neuropharmacology. 22:1988;801-804.
270. 1A receptor linked to adenylate cyclase (AC) in rat and guinea pig hippocampal preparations. Fed. Proc. 45:1986;436.
271. β receptors stably expressed in murine fibroblasts: inhibition of adenylyl cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G protein(s). Mol. Pharmacol. 44:1993;575-582.
272. 1A receptors by corticoid hormones. Mol. Brain Res. 29:1995;23-34.
273. Zifa E., Fillion G. 5-Hydroxytryptamine receptors. Pharmacol. Rev. 44:1992;401-458.