Novel and selective 5-HT(2C/2B) receptor antagonists as potential anxiolytic agents: Synthesis, quantitative structure - Activity relationships, and molecular modeling of substituted 1-(3- pyridylcarbamoyl)indolines

Journal of Medicinal Chemistry

Volumn 41, Issue 10, 1998, Pages 1598-1612

  Bromidge, Steven M ^a   Dabbs, Steven ^a   Davies, David T ^a   Duckworth, D Malcolm ^a   Forbes, Ian T ^a   Ham, Peter ^a   Jones, Graham E ^a   King, Frank D ^a   Saunders, Damian V ^a   Starr, Susannah ^a   Thewlis, Kevin M ^a   Wyman, Paul A ^a   Blaney, Frank E ^a   Naylor, Christopher B ^a   Bailey, Fiona ^a   Blackburn, Thomas P ^a   Holland, Vicky ^a   Kennett, Guy A ^a   Riley, Graham J ^a   Wood, Martyn D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 (METHYLTHIO) 1 (3 PYRIDYLCARBAMOYL) 6 (TRIFLUOROMETHYL)INDOLINE; 5 METHYLTHIO 1 (3 PYRIDYLCARBAMOYL) 6 (TRIFLUOROMETHYL)INDOLINE; ANXIOLYTIC AGENT; SEROTONIN 2B RECEPTOR; SEROTONIN 2C ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANXIETY NEUROSIS; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; CONDITIONING, OPERANT; CONFLICT (PSYCHOLOGY); INDOLES; MALE; MODELS, MOLECULAR; MOTOR ACTIVITY; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SOCIAL BEHAVIOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15144345036     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970741j     Document Type: Article

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