Selective visualization of rat brain 5-HT(2A) receptors by autoradiography with [3H]MDL 100,907

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 356, Issue 4, 1997, Pages 446-454

  López Giménez, Juan F ^a   Mengod, Guadalupe ^a   Palacios, José M ^a,b   Vilaró, M Teresa ^a  

^a INST D INVESTIGACIONS B   (Spain)

^b Almirall Prodesfarma S A   (Spain)

Author keywords

5 HT(2A) receptors; 3H ketanserin; 3H MDL100,907; 3H mesulergine; 3H RP62203; Autoradiography in situ hybridization; Rat brain

Indexed keywords

ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; KETANSERIN; MESULERGINE; RECEPTOR SUBTYPE; RITANSERIN; SPIPERONE;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN TISSUE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY;

ANIMALS; AUTORADIOGRAPHY; BINDING, COMPETITIVE; BRAIN; CYCLIC S-OXIDES; ERGOLINES; FLUOROBENZENES; GUANYLYL IMIDODIPHOSPHATE; IN SITU HYBRIDIZATION; KETANSERIN; MALE; NAPHTHALENES; PIPERIDINES; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RNA, MESSENGER; SEROTONIN ANTAGONISTS;

EID: 0030762185     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005075     Document Type: Article

References (46)

1. 1C receptors in rat brain. J Pharmacol Exp Ther 255:843-857
2. 2 serotonin receptors. J Neurochem 43:1213-1219
3. 2 receptor subtypes: a family re-united? Trends Pharmacol Sci 16:105-110
4. 2 receptors and serotoninergic axons in rat neocortex. Brain Res 455:315-328
5. 2 receptor. Mol Pharmacol 38:604-609
6. 50) of an enzymatic reaction. Biochem Pharmacol 22:2099-3108
7. 3H]Mesulergine, a selective ligand for serotonin-2 receptors. Life Sci 32:2485-2495A
8. 2 receptor antagonist. Br J Pharmacol 105:27-36
9. 2A receptor antagonist. Abstract 427.19, Society for Neuroscience, St. Louis
10. 4 receptor. Eur J Pharmacol 314:229-233
11. 2 recognition sites. Brain Res 376:97-107
12. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PPA (1994) VII. International union of pharmacology cassification of receptors for 5-Hydroxytryptamine (serotonin). Pharmacol Rev 46:157-203
13. 2A receptor ligand. Naunyn-Schmiedeberg's Arch Pharmacol 354:205-209
14. 2A antagonist with a favorable CNS safety profile. J Pharmacol Exp Ther 277:968-981
15. Lefkowitz RJ, Stadel JM, Caron MG (1983) Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization. Annu Rev Biochem 52:159-186
16. 2 receptors. Life Sci 28:1015-1022
17. 2 receptor binding sites. Mol Pharmacol 21:301-314
18. 3H]ketanserine binding sites in striatal membranes are associated with a dopac release system on dopaminergic nerve endings. Eur J Pharmacol 134:373-375
19. 2A receptors with positron emission tomography. Life Sci 58:187-192
20. 2 receptors. Mol Pharmacol 31:194-199
21. 2 receptor antagonist. In vitro and ex vivo selectivity profile. Eur J Pharmacol 233:29-35
22. 3H]RP 62203 binding in the rat brain. Eur J Pharmacol 233:37-45
23. 2A receptor antagonist. Eur J Pharmacol 259:137-141
24. McKenna DJ, Saavedra JM (1987) Autoradiography of LSD and 2,5-dimethoxyphenylisopropylamine psychomimetics demonstrates regional, specific cross-displacement in the rat brain. Eur J Pharmacol 142:313-315
25. 3H]LSD binding by rat brain slices in vitro: the effect of 5-hydroxytryptamine. Eur J Pharmacol 67:371-382
26. Mengod G, Nguyen H, Le H, Waeber C, Lübbert H, Palacios JM (1990) The distribution and cellular localization of the serotonin 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution. Neuroscience 35:577-591
27. 2 receptors in the rat brain. Neuroscience 54:701-717
28. Nazarali AJ, McKenna DJ, Saavedra JM (1989) Autoradiographic localization of 5HT2 receptors in rat brain using [125I]-DOI, a selective psychomimetic radioligand. Prog Neuropsychopharmacol Biol Psychiatry 13:573-581
29. 3H]Spiperone binding sites in brain: autoradiographic localization of multiple receptors. Brain Res 213:277-289
30. Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic Press, New York
31. Pazos A, Hoyer D, Palacios JM (1984) The binding of serotonin-ergic ligands to the porcine choroid plexus: characterization of a new tipe of recognition site. Eur J Pharmacol 106:539-546
32. Pazos A, Palacios JM (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res 346:205-230
33. Pazos A, Cortes R, Palacios JM (1985a) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res 346:231-249
34. Pazos A, Hoyer D, Palacios JM (1985b) Mesulergine, a selective serotonin-2 ligand in the rat cortex, does not label these receptors in porcine and human cortex: evidence for species differences in brain serotonin-2 receptors. Eur J Pharmacol 106:531-538
35. 3H]spiroperidol. Mol Pharmacol 16:687-699
36. 2b receptors. Mol Brain Res 23:163-178
37. Pritchett DB, Bach AWJ, Wozny M, Taleb O, Dal Toso R, Shih J, Seeburg PH (1988) Structure and functional expression of cloned rat serotonin 5HT-2 receptor. EMBO J 7:4135-4140
38. Rinaldi-Carmona M, Congy C, Santucci V, Simiand J, Gautret B, Neliat G, Labeeuw B, Le Fur G, Soubrie P, Breliere JC (1992) Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-Hydroxytryptamine2 receptor antagonist. J Pharmacol Exp Ther 262:759-768
39. Rinaldi-Carmona M, Congy C, Pointeau P, Vidal H, Brelière JC, Le Fur G (1993) Identification of binding sites for SR 46349B, a 5-Hydroxytryplamine2 receptor antagonist, in rodent brain. Life Sci 54:119-127
40. 3H]ketanserine recognition sites in rat striatum. J Neurochem 49:1833-1838
41. 2A receptor antagonist, MDL 100,907, increases dopamine efflux in the prefrontal cortex of the rat. Eur J Pharmacol 273:273-279
42. 2A receptors in antipsychotic activity. Life Sci 56:2209-2222
43. 125I]7-amino-8-iodo-ketanserine. Eur J Pharmacol 145:213-216A
44. 125I]7-amino-8-iodo-ketanserine. Eur J Pharmacol 172:99-106
45. 2 receptor antagonist MDL 100907 as a putative atypical antipsycotic: behavioral, electrophysiological and neurochemical studies. J Pharmacol Exp Ther 266:684-691
46. 2 receptor subtypes. Mol Pharmacol 38:594-598