Some benzenesulfonamido-substituted valerophenones that are selective antagonists for the 5-HT(2C) receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 22, 1996, Pages 2687-2692

  Weinhardt, Klaus K ^a   Bonhaus, Douglas W ^a   De Souza, Andrea ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 [4 (5 AMINO 2,4 DIMETHOXYBENZOYL)BUTYL] 1,3,8 TRIAZASPIRO[4.5]DECANE 2,4 DIONE; BENZENESULFONAMIDE DERIVATIVE; KETANSERIN; MESULERGINE; SEROTONIN; SEROTONIN 1C RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN ANTAGONIST; SPIPERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GENE EXPRESSION; HUMAN; MOLECULAR CLONING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 0030593860     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00503-3     Document Type: Article

References (13)

1. 1. (a) Review: Homer, D.; Clarke, D. E.; Fozard, J. R.; Hartig, P. R.; Martin, G. R.; Mylecharane, E. J.; Saxena, P. R.; Humphrey, P. P. A. Pharmacol. Rev. 1994, 46, 157.
2. (b) Lucaites, V. L.; Nelson, D. L.; Wainscott, D. B.; Baez, M. Life Sci. 1996, 59, 1081.
3. 2. Reviews: (a) Kennet, G. A.; Wood, M. D.; Forbes, I. T.; Ham, P.; Jones, G. E.; Baxter, G. S.; Blackburn, T. P. Int. Congr. Ser. 1995, 1088, 113.
4. (b) Kennet, G. A. Curr. Opin. Invest. Drugs 1993, 2, 317.
5. 3. (a) Fox, S.; Brotchie, J. Eur. J. Pharmacol. 1996, 301, 27.
6. (b) Kennet, G. A.; Pittaway, K.; Blackburn, T. P. Psychopharmacol. 1994, 114, 90.
7. 4. (a) Kennet, G. A.; Wood, M. D.; Bright, F.; Cilia, J.; Piper, D. C.; Gager, T.; Thomas, D.; Baxter, G. S.; Forbes, I. T.; Ham, P. Brit. J. Pharmacol. 1996, 117, 427.
8. (b) Kennet, G. A.; Bailey, F.; Piper, D. C.; Blackburn, T. P. Psychopharmacology 1995, 118, 178.
9. (c) Forbes, I. T.; Ham, P.; Booth, D. H.; Martin, R. T.; Thompson, M.; Baxter, G. S.; Blackburn, T. P.; Glen, A; Kennett, G. A.; Wood, M. D. J. Med. Chem. 1995, 38 , 2524.
10. (d) Nozulak, J.; Kalkman, H. O.; Floerscheim, P.; Hoyer, D.; Schoeffter, P.; Burki, H. R. J. Med. Chem. 1995, 38 , 28.
11. 5. Clark, R. D.; Jahangir, A.; Langston, J. A.; Weinhardt, K. K.; Miller, A. B.; Leung, E.; Bonhaus, D. W.; Wong, E. H. F.; Eglen, R. M. Bioorg. Med. Chem. Lett. 1994, 4 , 2481.
12. 2C receptors.
13. 7. McConnell, H. M.; Owiki, J. C., Parce, J. W.; Miller, D. L.; Baxter, G. T.; Wada, H. G.; Pitchford, S. Science 1992, 257, 1906.