DOI disrupts prepulse inhibition of startle in rats via 5-HT(2A) receptors in the ventral pallidum

Brain Research

Volumn 761, Issue 1, 1997, Pages 97-104

  Sipes, Thomas E ^a   Geyer, Mark A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hallucinogens; Prepulse inhibition; Schizophrenia; Sensorimotor gating; Serotonin 2A; Startle

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; SEROTONIN 2A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; GABAERGIC SYSTEM; GLOBUS PALLIDUS; HUNTINGTON CHOREA; INTERNEURON; MALE; NONHUMAN; OBSESSION; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION; SEROTONINERGIC SYSTEM; STARTLE REFLEX;

AMPHETAMINES; ANIMALS; FLUOROBENZENES; GLOBUS PALLIDUS; HALLUCINOGENS; MALE; MICROINJECTIONS; NEURAL INHIBITION; NUCLEUS ACCUMBENS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STARTLE REACTION;

EID: 0030750579     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00316-8     Document Type: Article

References (41)

1. 1c receptors in rat brain. J. Pharmacol. Exp. Ther. 255:1990;843-857.
2. Braff D.L., Grillon C., Geyer M.A. Gating and habituation of the startle reflex in schizophrenic patients. Arch. Gen. Psychiatry. 49:1992;206-215.
3. Cools A.R. Role of neostriatal dopaminergic activity in sequencing and selecting behavioral strategies: facilitation of processes involved in selecting the best strategy in a stressful situation. Behav. Brain Res. 1:1980;361-378.
4. Ebert U., Ostwald J. The mesencephalic locomotor region is activated during the auditory startle response of the unrestrained rat. Brain Res. 565:1991;209-217.
5. Geyer, M.A. and Markou, A., Animal models of psychiatric disorders, in: F.E. Bloom, D.J. Kupfer (Eds.), Psychopharmacology: the Fourth Generation of Progress, Raven Press, New York, NY, 1995, pp. 787-798.
6. Graham F.K. The more or less startling effects of weak prestimuli. Psychophysiology. 12:1975;238-248.
7. Groenewegen H.J., Berendse H.W., Haber S.N. Organization of the output of the ventral striatopallidal system in the rat: ventral pallidal efferents. Neuroscience. 57:1993;113-142.
8. Haber S.N., Groenewegen H.J., Grove E.A., Nauta W.J.H. Efferent connections of the ventral pallidum: evidence of a dual striatopallidofugal pathway. J. Comp. Neurol. 235:1985;322-335.
9. Insel T. Toward a neuroanatomy of obsessive-compulsive disorder. Arch. Gen. Psychiatry. 49:1992;739-744.
10. Joyce J.N., Shane A., Lexow N., Winokur A., Casanova M.F., Kleinman J.E. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology. 8:1993;315-336.
11. 2A antagonist with a favorable CNS safety profile. J. Pharmacol. Exp. Ther. 277:1996;968-981.
12. Koch M., Kungel M., Herbert H. Cholinergic neurons in the pedunculopontine tegmental nucleus are involved in the mediation of prepulse inhibition of the acoustic startle response in the rat. Exp. Brain Res. 97:1993;71-82.
13. Kodsi M.H., Swerdlow N.R. Quinolinic acid lesions of the ventral striatum reduce sensorimotor gating of acoustic startle in rats. Brain Res. 643:1994;59-65.
14. Leitner D.S., Powers A.S., Stitt C.L., Hoffman H.S. Midbrain reticular formation involved in the inhibition of acoustic startle. Physiol. Behav. 26:1981;259-268.
15. Lingenhohl K., Friauf E. Giant neurons in the rat reticular formation: a sensorimotor interface in the elementary acoustic startle circuit? J. Neurosci. 14:1994;1176-1194.
16. Mansbach R.S., Braff D.L., Geyer M.A. Prepulse inhibition of the acoustic startle response is disrupted by N-ethyl-3,4-methylenedioxyamphetamine (MDEA) in the rat. Eur. J. Pharmacol. 167:1989;49-55.
17. Martinez D.L., Geyer M.A. Characterization of the disruptions of prepulse inhibition and habituation of startle induced by α-ethyltryptamine. Neuropsychopharmacology. 16:1997;246-255.
18. Meltzer H.Y. The mechanism of action of novel antipsychotic drugs. Schizophr. Bull. 17:1991;263-287.
19. Mink J.W., Thach W.T. Basal ganglia intrinsic circuits and their role in behavior. Curr. Opin. Neurobiol. 3:1993;950-957.
20. Morilak D.A., Garlow S.J., Ciaranello R.D. Immunocytochemical localization and description of neurons expressing serotonin2 receptors in the rat brain. Neuroscience. 54:1993;701-717.
21. 2 receptors in the rat brain: neurochemical identification of cell types by immunocytochemistry. Neuropsychopharmacology. 11:1994;157-166.
22. Nauta W.H.J., Smith G.P., Faull R.L.M., Domesick V.B. Efferent connections and nigral afferents of the nucleus accumbens septi in the rat. Neuroscience. 3:1978;385.
23. 2C antagonist, Soc. Neurosci. Abstr., 126.11 (1993).
24. 2A antagonist MDL 100,907 on disruption of sound and light prepulse inhibition produced by 5-HT agonists in Wistar rats Psychopharmacology. 124:1996;107-116.
25. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, 2nd edn., Academic Press, San Diego, CA, 1986.
26. Penney J.B., Young A.B. Speculations on the functional anatomy of basal ganglia disorders. Annu. Rev. Neurosci. 6:1983;73-94.
27. Rigdon G.C., Weatherspoon J.K. 5-Hydroxytryptamine-1a receptor agonists block prepulse inhibition of acoustic startle reflex. J. Pharmacol. Exp. Ther. 263:1992;486-493.
28. Robbins T.W., Everitt B.J. Functional studies of central catecholamines. Int. Rev. Neurobiol. 23:1982;303-365.
29. Sipes T.A., Geyer M.A. Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats. Neuropharmacology. 33:1994;441-448.
30. Sipes T.A., Geyer M.A. 8-OH-DPAT disruption of prepulse inhibition in the rat: localization of site of action with WAY 100,135. Psychopharmacology. 117:1995;41-48.
31. 2C receptors. Behav. Pharmacol. 6:1995;839-842.
32. 2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J. Pharmacol. Exp. Ther. 266:1993;684-691.
33. Swerdlow N.R., Benbow C.H., Zisook S., Geyer M.A., Braff D.L. A preliminary assessment of sensorimotor gating in patients with obsessive compulsive disorder. Biol. Psychiatry. 33:1993;298-301.
34. Swerdlow, N.R., Braff, D.L., Caine, S.B., Geyer M.A., Limbic cortico-striato-pallido-pontine substrates of sensorimotor gating in animal models and psychiatric disorders, in: P.W. Kalivas, C.D. Barnes (Eds.), Limbic Motor Circuits and Neuropsychiatry, CRC Press, Boca Raton, FL, 1993, pp. 311-328.
35. Swerdlow N.R., Braff D.L., Geyer M.A. GABAergic projection from nucleus accumbens to ventral pallidum mediates dopamine-induced sensorimotor gating deficits of acoustic startle in rats. Brain Res. 532:1990;146-150.
36. Swerdlow N.R., Braff D.L., Geyer M.A., Koob G.F. Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics. Biol. Psychiatry. 21:1986;23-33.
37. Swerdlow N.R., Geyer M.A. Prepulse inhibition of acoustic startle in rats after lesions of the pedunculopontine tegmental nucleus. Behav. Neurosci. 107:1993;104-117.
38. Swerdlow N.R., Paulsen J., Braff D.L., Butters N., Geyer M.A., Swenson M.R. Impaired prepulse inhibition of acoustic startle and tactile startle response in patients with Huntington's disease. J. Neurol. Neurosurg. Psychiatry. 58:1995;192-200.
39. Winslow J.T., Insel T.R. Neurobiology of obsessive compulsive disorder: a possible role for serotonin. J. Clin. Psychiatry. 51(Suppl.):1990;27-31.
40. Wu M.F., Mallick B.N., Siegel J.M. Lateral geniculate spikes, muscle atonia and startle response elicited by auditory stimuli as a function of stimulus parameters and arousal state. Brain Res. 499:1989;7-17.
41. Wu M.F., Suzuki S.S., Siegel J.M. Anatomical distribution and response patterns of reticular neurons active in relation to acoustic startle. Brain Res. 457:1988;399-406.