Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system

Neuroscience

Volumn 76, Issue 2, 1997, Pages 323-329

  Duxon, M S ^a   Flanigan, T P ^b   Reavley, A C ^b   Baxter, G S ^c   Blackburn, T P ^c   Fone, K C F ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT(2B) receptor; Amygdala; Immunohistochemistry; Septum; Serotonin; Stomach fundus

Indexed keywords

SEROTONIN 2B RECEPTOR;

AMYGDALOID NUCLEUS; ANIMAL TISSUE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; GENE EXPRESSION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; SEPTUM NUCLEUS; SHORT SURVEY; STOMACH FUNDUS;

EID: 0031024060     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(96)00480-0     Document Type: Article

References (28)

1. 2C receptor protein in human and rat brain using specific antisera. Neuropharmacology 34, 1635-1645.
2. 2B receptors in the rat CNS causes hyperphagia and alters the aversive response to ultrasound. J. Psychopharmac. 10, A45.
3. 2B receptor function? Br. J. Pharmac. 117, 178P.
4. 2 receptor subtypes: a family re-united? Trends pharmac. Sci. 16, 105-110.
5. 2B) in rat stomach fundus longitudinal muscle. Br. J. Pharmac. 112, 323-331.
6. 1C receptor. J. Pharmac. exp. Ther. 264, 709-716.
7. 2C receptors. Br. J. Pharmac. 115, 622-628.
8. 2B receptor: homologous subtype or species variant. Behav. Brain Res. 73, 253-257.
9. 2B receptor agonist BW 723C86 produces anxiolysis on the elevated plus-maze in the rat. Br. J. Pharmac. 116, 331P.
10. 2B receptors of endothelium-dependent relaxation in rat jugular-vein. Br. J. Pharmac. 114, 400-404.
11. 2B receptor mRNA in rat brain. Br. J. Pharmac. 114, 369P.
12. Foguet M., Hoyer D., Pardo L. A., Parekli A., Kluxen F. W., Kalkman H. O., Stuhmer W. and Lubbert H. (1992) Cloning and functional characterization of the rat stomach fundus serotonin receptor. Eur. molec. Biol. Org. J. 11, 3481-3487.
13. 2 and stomach fundus receptor genes. NeuroReport 3, 345-348.
14. Helton L. A., Thor K. B. and Baez M. (1994) 5-Hydroxytryptamine(2A), 5-hydroxytryptamine(2B), and 5-hydroxytryptamine(2C) receptor messenger-RNA expression in the spinal-cord of rat, cat, monkey and human. NeuroReport 5, 2617-2620.
15. Hoyer D., Clarke D. E., Fozard J. R., Hartig P. R., Martin G. R., Mylecharane E. J., Saxena P. R. and Humphrey P. P. A. (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmac. Rev. 46, 157-204.
16. 2C receptor blockade? Life Sci. 54, 641-644.
17. 2B receptor agonist, BW 723C86, on three rat models of anxiety. Br. J. Pharmac. 117, 1443-1448.
18. 2B receptor. Molec. Pharmac. 46, 227-234.
19. 2F) from rat stomach fundus. Molec. Pharmac. 42, 549-557.
20. 2B receptor. J. biol. Chem. 271, 3141-3147.
21. Loric S., Launeay J.-M. and Colas J. F. (1992) New mouse 5-HT2-like receptor: expression in brain, heart and intestine. Fedn Eur. biochem. Socs Lett. 312, 203-207.
22. Loric S., Maroteaux L., Kellermann O. and Launay J. M. (1995) Functional serotonin-2b receptors are expressed by a teratocarcinoma-derived cell-line during serotoninergic differentiation. Molec. Pharmac. 47, 458-466.
23. 2 receptors, in the rat brain. Neuroscience 54, 701-717.
24. 2C receptors. Molec. Brain Res. 23, 163-178.
25. Randall M. D. and Hiley C. R. (1988) Detergent and methylene blue affect endothelium-dependent vasorelaxation and pressure/flow relations in rat blood perfused mesenteric arterial bed. Br. J. Pharmac. 95, 1081-1088.
26. 2B serotonin receptor. Fedn Eur. biochem. Socs Lett. 342, 85-90.
27. 2C receptor protein in adult rat brain and spinal cord determined using a receptor-directed antibody; effect of 5,7-dihydroxytryptamine. Synapse (in press).
28. 2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats. Hypertension 26, 1056-1059.