Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells

Molecular and Cellular Biology

Volumn 19, Issue 2, 1999, Pages 1289-1300

  Gorospe, Myriam ^a   Egan, Josephine M ^a   Zbar, Berton ^b   Lerman, Michael ^b   Geil, Laura ^b   Kuzmin, Igor ^b   Holbrook, Nikki J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL CULTURE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; COLONY FORMATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SUPPRESSOR GENE;

EID: 0032908982     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.2.1289     Document Type: Article

References (59)

1. Aso, T., D. Haque, R. J. Barstead, R. C. Conaway, and J. W. Conaway. 1996. The inducible elongin A elongation activation domain: structure, function and interaction with elongin BC complex. EMBO J. 15:101-110.
2. Baumeister, W., J. Walz, F. Zuhl, and E. Seemuller. 1998. The proteasome: paradigm of a self-compartmentalizing protease. Cell 92:367-380.
3. Brayden, D. J., M. R. Hanley, O. Thastrup, and A. W. Cuthbert. 1989. Thapsigargin, a new calcium-dependent epithelial anion secretagogue. Br. J. Pharmacol. 98:809-816.
4. Carlson, S. G., T. W. Fawcett, J. D. Bartlett, M. Bernier, and N. J. Holbrook. 1993. Regulation of the C/EBP-related gene gadd153 by glucose deprivation. Mol. Cell. Biol. 13:4736-4744.
5. Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991-1995.
6. Corless, C. L., A. S. Kibel, O. Iliopoulos, and W. G. Kaelin. Jr. 1997. Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues. Hum. Pathol. 28:459-464.
7. Duan, D. R., A. Pause, W. Burgess, T. Aso, D. Y. T. Chen, K. P. Garrett, R. C. Conaway, J. W. Conaway, W. M. Linehan, and R. D. Klausner. 1995. Inhibition of transcriptional elongation by the VHL tumor suppressor protein. Science 269:1402-1406.
8. Feldman, R. M., C. C. Correll, K. B. Kaplan, and R. J. Deshaies. 1997. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91:221-230.
9. Field, S. J., F. Y. Tsai, F. Kuo, A. M. Zubiaga, W. G. Kaelin, Jr., D. M. Livingston, S. H. Orkin, and M. E. Greenberg. 1996. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85:549-561.
10. Fornace, A. J., Jr., I. J. Alamo, M. C. Hollander, and E. Lamoreaux. 1989. Induction of heat shock protein transcripts and B2 transcripts by various stresses in Chinese hamster cells. Exp. Cell Res. 182:61-74.
11. Garrett, K. P., T. Aso, J. N. Bradsher, S. I. Foundling, W. S. Lane, R. C. Conaway, and J. W. Conaway. 1995. Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. Proc. Natl. Acad. Sci. USA 92:7172-7176.
12. Gnarra, J. R., D. R. Duan, Y. Weng, J. S. Humphrey, D. Y. T. Chen, S. Lee, A. Pause, F. Dudley, F. Latif, I. Kuzmin, L. Schmidt, F.-M. Duh, T. Stackhouse, F. Chen, T. Kishida, M. H. Wei, M. I. Lerman, B. Zbar, R. D. Klausner, and W. M. Linehan. 1996. Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal cell carcinoma. Biochim. Biophys. Acta 1242:201-210.
13. Gnarra, J. R., S. Zhou, M. J. Merrill, J. R. Wagner, A. Krumm, E. Papavassiliou, E. H. Oldfield, R. D. Klausner, and W. M. Linehan. 1996. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc. Natl. Acad. Sci. USA 93:10589-10594.
14. Gnarra, J. R., J. M. Ward, F. D. Porter, J. R. Wagner, D. E. Devor, A. Grinberg, M. R. Emmert-Buck, H. Westphal, R. D. Klausner, and W. M. Linehan. 1997. Defective placental vasculogenesis causes embryonic lethality in VHL-delicient mice. Proc. Natl. Acad. Sci. USA 94:9102-9107.
15. Goldberg, M. A., S. P. Dunning, and H. F. Bunn. 1988. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242:1412-1415.
16. 2-mediated growth arrest. Mol. Cell. Biol. 16:762-70.
17. 2-mediated cellular arrest and death. Cancer Res. 56:475-479.
18. Grossman, H. B., G. Wedemeyer, and L. Q. Ren. 1985. Human renal carcinoma: characterization of five new cell lines. J. Surg. Oncol. 28:237-244.
19. Guillemain, I., and J. H. Exton. 1997. Effects of brefeldin A on phosphatidylcholine phospholipase D and inositolphospholipid metabolism in HL-60 cells. Eur. J. Biochem. 249:812-819.
20. Humphrey, J. S., R. D. Klausner, and W. M. Linehan. 1996. Von Hippel-Lindau syndrome: hereditary cancer arising from inherited mutations of the VHL tumor suppressor gene. Cancer Treat. Res. 88:13-39.
21. Iliopoulos, O., A. Kibel, S. Gray, and W. G. Kaelin, Jr. 1995. Tumor suppression by the human von Hippel-Lindau gene product. Nat. Med. 1:822-826.
22. Iliopoulos, O., A. P. Levy, C. Jiang, W. G. Kaelin, Jr., and M. A. Goldberg. 1996. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc. Natl. Acad. Sci. USA 93:10595-10599.
23. Iliopoulos, O., and W. G. Kaelin, Jr. 1997. The molecular basis of von Hippel-Lindau disease. Mol. Med. 3:289-293.
24. Jackson, P. K. 1996. Cell cycle: cull and destroy. Curr. Biol. 6:1209-1212.
25. Jiang, B. H., F. Agani, A. Passaniti, and G. L. Semenza. 1997. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res. 57:5328-5335.
26. Kibel, A., O. Iliopoulos, J. D. DeCaprio, and W. G. Kaelin, Jr. 1995. Binding of the von Hippel-Lindau tumor suppressor protein to elongin B and C. Science 269:1444-1446.
27. Kim, Y. H., J. J. Proust, M. J. Buchholz, F. J. Chrest, and A. A. Nordin. 1992 Expression of the murine homologue of the cell cycle control protein p34cdc2 in T lymphocytes. J. Immunol. 149:17-23.
28. Kipreos, E. T., L. E. Lander, J. P. Wing, W. W. He, and E. M. Hedgecock. 1996. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85:829-839.
29. Kishida, T., T. M. Stackhouse, F. Chen, M. I. Lerman, and B. Zbar. 1995. Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations. Cancer Res. 55:4544-4548.
30. Korsmeyer, S. J. 1992. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 80:879-886.
31. Lee, S., D. Y. T. Chen, J. S. Humphrey, J. R. Gnarra, W. M. Linehan, and R. D. Klausner. 1996. Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density. Proc. Natl. Acad. Sci. USA 93:1770-1775.
32. Lee, A. S. 1987. Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells. Trends Biochem. Sci. 12:20-23.
33. Levy, A. P., N. S. Levy, and M. A. Goldberg. 1996. Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein. J. Biol. Chem. 271:25492-25497.
34. Levy, A. P., N. S. Levy, O. Iliopoulos, C. Jiang, W. G. Kaelin, Jr., and M. A. Goldberg. 1997. Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene. Kidney Int. 51:575-578.
35. Lisztwan, J., A. Marti, H. Sutterluty, M. Gstaiger, C. Wirbelauer, and W. Krek. 1998. Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein 45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. EMBO J. 17:368-383.
36. Lonergan, K. M., O. Iliopoulos, M. Ohh, T. Kamura, R. C. Conaway, J. W. Conaway, and W. G. Kaelin, Jr. 1998. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Mol. Cell. Biol. 18:732-741.
37. Lowe, S. W., H. E. Ruley, T. Jacks, and D. E. Housman. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967.
38. Maher, E. R., and W. G. Kaelin, Jr. 1997. von Hippel-Lindau disease. Medicine 76:381-391.
39. Maltepe, E., J. V. Schmidt, D. Baunoch, C. A. Bradfield, and M. C. Simon. 1997. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386:403-407.
40. Maxwell, P. H., G. U. Dachs, J. M. Gleadle, L. G. Nicholls, A. L. Harris, I. J. Stratford, O. Hankinson, C. W. Pugh, and P. J. Ratcliffe. 1997. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl. Acad. Sci. USA 94:8104-8109.
41. Morinaga, N., J. Moss, and M. Vaughan. 1997. Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor. Proc. Natl. Acad. Sci. USA 94:12926-12931.
42. Mukhopadhyay, D., B. Knebelmann, H. T. Cohen, S. Ananth, and V. P. Sukhatme. 1997. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity. Mol. Cell. Biol. 17:5629-5639.
43. Núñez, G., D. Hockenbery, T. J. McDonnell, C. M. Sorensen, and S. J. Korsmeyer. 1991. Bcl-2 maintains B cell memory. Nature 353:71-73.
44. Pause, A., S. Lee, R. A. Worrell, D. Y. T. Chen, W. H. Burgess, W. M. Linehan, and R. D. Klausner. 1997. The von Hippel-Lindau tumor suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Natl. Acad. Sci. USA 94:2156-2161.
45. Paton, E. E., A. R. Willens, D. Sa, L. Kuras, D. Thomas, K. L. Craig, and M. Tyers. 1998. Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast. Genes Dev. 12:692-705.
46. Pickart, C. M. 1997. Targeting of substrates to the 26S proteasome. FASEB J. 11:1055-1066.
47. Reed, J. C. 1995. Bcl-2: prevention of apoptosis as a mechanism of drug resistance. Hematol. Oncol. Clin. North Am. 9:451-473.
48. Rubin, D. M., and D. Finley. 1995. Proteolysis. The proteasome: a protein-degrading organelle? Curr. Biol. 5:854-858.
49. Sato, K., K. Terada, T. Sugiyama, S. Takahashi, M. Saito, M. Moriyama, H. Kakinuma, Y. Suzuki, M. Kato, and T. Kato. 1994. Frequent overexpression of vascular endothelial growth factor gene in human renal cell carcinoma. Tohoku J. Exp. Med. 173:355-360.
50. Shweiki, D., M. Neeman, A. Itin, and E. Keshet. 1995 Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis. Proc. Natl. Acad. Sci. USA 92:768-772.
51. Siemeister, G., K. Weindel, K. Mohrs, B. Barleon, G. Martiny-Baron, and D. Marme. 1996. Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res. 56:2299-2301.
52. Sommer, T., and H. W. Dieter. 1997. Endoplasmic reticulum degradation: reverse protein flow of no return. FASEB J. 11:1127.
53. Stein, I., M. Neeman, D. Shweiki, A. Itin, and E. Keshet. 1995. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol. Cell. Biol. 15: 5363-5368.
54. Takahashi, A., H. Sasaki, S. J. Kim, K. Tobisu, T. Kakizoe, T. Tsukamoto, Y. Kumamotu, T. Sugimura, and M. Terada. 1994. Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res. 54:4233-4237.
55. Ting, J., S. K. Wooden, R. Kriz, K. Kelleher, R. J. Kaufman, and A. S. Lee. 1987. The nucleotide sequence encoding the hamster 78-kDa glucose-regulated protein (GRP78) and its conservation between hamster and rat. Gene 55:147-52.
56. Thastrup, O., A. P. Dawson, O. Scharff, B. Hoder, P. J. Cullen, B. K. Drobak, P. J. Bjerrum, S. B. Christensen, and M. R. Hanley. 1989. Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. Agents Actions 27:17-23.
57. Tsai, F. H., C. G. Overberger, and R. Zand. 1990. Synthesis and peptide bond orientation in tetrapeptides containing L-azetidine-2-carboxylic acid and L-proline. Biopolymers 30:1039-1049.
58. Watowich, S. S., and R. I. Morimoto. 1988. Complex regulation of heat shock- and glucose-responsive genes in human cells. Mol. Cell. Biol. 8:393-405.
59. Wizigmann-Voos, S., G. Breier, W. Risau, and K. Plate. 1995. Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res. 55:1358-1364.