Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair

EMBO Journal

Volumn 20, Issue 23, 2001, Pages 6660-6671

  Hartsuiker, E ^a   Vaessen, E ^b   Carr, A M ^a   Kohli, J ^c  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY OF FRIBOURG   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

DNA replication; Rad21; Rad50; Recombinational DNA repair; Sister chromatid cohesion

Indexed keywords

DNA; FUNGAL PROTEIN; PROTEIN RAD21; RAD50 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE S PHASE; DNA REPLICATION; FUNGAL GENETICS; GENE DELETION; GENETIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SISTER CHROMATID; YEAST;

AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL CYCLE PROTEINS; CELL SEPARATION; CHROMOSOME DELETION; CLONING, MOLECULAR; CROSSES, GENETIC; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; EPISTASIS, GENETIC; FLOW CYTOMETRY; FUNGAL PROTEINS; GAMMA RAYS; GENE DELETION; GENOTYPE; HUMANS; HYDROXYUREA; METHYL METHANESULFONATE; MICE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHOSPHOPROTEINS; RECOMBINATION, GENETIC; S PHASE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SISTER CHROMATID EXCHANGE; TELOMERE; TIME FACTORS;

EID: 0035803488     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.23.6660     Document Type: Article

References (68)

1. Characterization of Schizosaccharomyces pombe Rad2 protein, a FEN-1 homolog
2. A site- and strand-specific DNA break confers asymmetric switching potential in fission yeast
3. Fission yeast switches mating type by a replication-recombination coupled process
4. Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe
5. Enzymes and reactions at the eukaryotic DNA replication fork
6. Cloning and characterization of rad21, an essential gene of Schizosaccharomyces pombe involved in DNA double-strand-break repair
7. The rad21 gene product of Schizosaccharomyces pombe is a nuclear, cell cycle-regulated phosphoprotein
8. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
9. The Mrell-Rad50-Xrs2 protein complex facilitates homologous recombination-based double strand break repair in Saccharomyces cerevisiae
10. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
11. Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p
12. Repair of MMS-induced DNA double-strand breaks in haploid cells of Saccharomyces cerevisiae, which requires the presence of a duplicate genome
13. Inhibition of deoxyribonucleic acid synthesis and replicon elongation in mammalian cells exposed to methyl methanesulfonate
14. Orientation of DNA replication establishes mating-type switching pattern in S.pombe
15. The yeast Xrs2 complex functions in S phase checkpoint regulation
16. Human Rad50 is physically associated with human Mre11: Identification of a conserved multiprotein complex implicated in recombinational DNA repair
17. - mutants of Schizosaccharomyces pombe
18. DNA double-strand breaks and the RAD50-RAD57 genes in Saccharomyces
19. Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis
20. Mammalian telomeres end in a large duplex loop
21. Schizosaccharomyces pombe
22. The many interfaces of Mre11
23. Sister chromatid cohesion and recombination in meiosis
24. A sequence property approach to searching protein databases
25. High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S.pombe
26. Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily
27. Mutations in XRS2 and RAD50 delay but do not prevent mating type switching in Saccharomyces cerevisiae
28. Recombination in telomerelength maintenance
29. A new recombinational DNA repair gene from Schizosaccharomyces pombe with homology to Escherichia coli RecA
30. Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae
31. Initiation of genetic recombination and recombination-dependent replication
32. Two enzymes are required for strand incision in repair of alkylated DNA
33. The distribution of the number of mutants in bacterial populations
34. The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair
35. Tying up loose ends: Nonhomologous end-joining in Saccharomyces cerevisiae
36. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development and sensitivity to ionizing radiation
37. The RAD50 gene, a member of the double strand break repair epistasis group, is not required for spontaneous mitotic recombination in yeast
38. Novel functional requirements for nonhomologous DNA end joining in Schizosaccharomyces pombe
39. The RAD52 recombinational repair pathway is essential in pol30 (PCNA) mutants that accumulate small single-stranded DNA fragments during DNA synthesis
40. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
41. Cloning the RAD51 homologue of Schizosaccharomyces pombe
42. Isolation of the Schizosaccharomyces pombe rad54 homologue, rhp54, a gene involved in the repair of radiation damage and replication fidelity
43. + genes
44. Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage
45. Two modes of survival of fission yeast without telomerase
46. Telomere-associated chromosome breakage in fission yeast results in variegated expression of adjacent genes
47. Telomere maintenance is dependent on activities required for end repair of double-strand breaks
48. Mutations in the MRE11, RAD50, XRS2 and MRE2 genes alter chromatin configuration at meiotic DNA double-stranded break sites in premeiotic and meiotic cells
49. The fission yeast rad22 gene, having a function in mating-type switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiae
50. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
51. The mammalian Mre11-Rad50-Nbs1 protein complex: Integration of functions in the cellular DNA-damage response
52. The Mre11 complex and ATM: Collaborating to navigate S phase
53. The RAD52 epistasis group in mammalian double strand break repair
54. Architectural features of pre-mRNA introns in the fission yeast Schizosaccharomyces pombe
55. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit
56. The ade6-M26 mutation of Schizosaccharomyces pombe increases the frequency of crossing over
57. Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast
58. Structural maintenance of chromosomes (SMC) proteins. Conserved molecular properties for multiple biological functions
59. The smt-0 mutation, which abolishes mating-type switching in fission yeast is a deletion
60. Cloning and characterization of the Schizosaccharomyces pombe rad32 gene: A gene required for repair of double strand breaks and recombination
61. The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres
62. Cohesion between sister chromatids must be established during DNA replication
63. A DNA damage response pathway controlled by Te11 and the Mre11 complex
64. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
65. Distantly related sequences in the α- and β-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
66. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
67. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres