Two modes of survival of fission yeast without telomerase

Science

Volumn 282, Issue 5388, 1998, Pages 493-496

  Nakamura, Toru M ^a   Cooper, Julia Promisel ^b   Cech, Thomas R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TELOMERASE;

CONTROLLED STUDY; DNA BINDING; GENE DELETION; GENETIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SCHIZOSACCHAROMYCES POMBE; SURVIVAL; TELOMERE;

CHROMOSOMES, FUNGAL; DNA PROBES; DNA, FUNGAL; DNA-BINDING PROTEINS; GENE DELETION; GENES, FUNGAL; PROTEINS; RECOMBINATION, GENETIC; RNA; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TELOMERASE; TELOMERE; TELOMERE-BINDING PROTEINS;

SCHIZOSACCHAROMYCES POMBE;

EID: 3543142313     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.282.5388.493     Document Type: Review

References (38)

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15. + genes are homologous to the human ATM (ataxia-telangiectasia mutated) gene.
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17. - survivors with linear chromosomes. In addition, the possibility that chromosome circularization itself may require recombination (9) complicates the analysis.
18. - survivors with linear chromosomes. In addition, the possibility that chromosome circularization itself may require recombination (9) complicates the analysis.
19. - survivors with linear chromosomes. In addition, the possibility that chromosome circularization itself may require recombination (9) complicates the analysis.
20. - survivors with linear chromosomes. In addition, the possibility that chromosome circularization itself may require recombination (9) complicates the analysis.
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26. - cells with linear chromosomes ran normally in the PFGE gels and maintained telomere and TAS hybridization signals.
27. J. P. Cooper and T. R. Cech, unpublished observations.
28. - survivors.
29. - cells by transformation of the pWH5-trt1 plasmid produced a strong increase in telomeric-repeat hybridization signal.
30. Growth rates were determined by measuring absorbance at 600 nm of exponentially growing cells in yeast extract medium supplemented (YES) liquid culture (20) at 32°C every 30 min.
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38. We thank J. Sperger for discussions and comments on the manuscript, other members of T.R.C.'s lab for discussions, and N. Sugawara for the pNSU70 plasmid. Supported by NIH grant GM28039 (T.R.C.).