Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions

Nature Genetics

Volumn 21, Issue 2, 1999, Pages 204-208

  Corda, Yves ^a   Schramke, Vera ^a   Longhese, Maria Pia ^b   Smokvina, Tamara ^a   Paciotti, Vera ^b   Brevet, Vanessa ^c   Gilson, Eric ^c   Géli, Vincent ^a  

^a CNRS   (France)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITÉ DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME PROTEIN;

ARTICLE; DNA DAMAGE; DNA REPAIR; GENE DELETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; TELOMERE; TRANSCRIPTION REGULATION;

CELL CYCLE; CELL CYCLE PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA REPAIR; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TELOMERE; TRANSCRIPTION FACTORS;

EID: 0032954261     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/5991     Document Type: Article

References (30)

1. Nislow, C., Ray, E. & Pillus, L. SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular mechanisms. Mol. Biol. Cell 8, 2421-2436 (1997).
2. Jenuwein, T., Laible, G., Dorn, R. & Reuter, G. SET domain proteins modulate chromatin domains in eu-and heterochromatin. Cell. Mol. Life Sci. 54, 80-93 (1998).
3. Weinert T.A., Kiser, G.L. & Hartwell, L.H. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8, 652-665 (1994).
4. Lydall, D. & Weinert, T.A. Yeast checkpoint genes in DNA damage and processing: implications for repair and arrest. Science 270, 1488-1491 (1995).
5. Longhese, M.P., Fraschini, R., Plevani, P. & Lucchini, G. Yeast pip3/MEC3 mutants fail to delay entry into S phase and to slow down DNA replication in response to DNA damage and they define a functional link between Mec3 and DNA primase. Mol. Cell. Biol. 16, 3225-3244 (1996).
6. Longhese, M.P. et al. The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in yeast. EMBO J. 16, 5216-5226 (1997).
7. Paciotti, V., Lucchini, G., Plevani, P. & Longhese, M.P. Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p. EMBO J. 17, 4199-4209 (1998).
8. Allen, J.B., Zhou, Z., Siede, W., Friedberg, E.C. & Elledge, S.J. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 8, 2416-2428 (1994).
9. Sun, Z., Fay, D.S., Marini, F., Foiani, M. & Stern, D.F. Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10, 395-406 (1996).
10. Jones, R.S. & Gelbart, W.M. The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax. Mol. Cell. Biol. 13, 6357-6366 (1993).
11. Tschiersh, B. et al. The protein encoded by the Drosophila position effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J. 13, 3822-3831 (1994).
12. Stassen, M.J., Bailey, D., Nelson S., Chinwalla, V. & Harte, P.J. The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins. Mech. Dev. 52, 209-223 (1995).
13. Laible, G. et al. Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 16, 3219-3232 (1997).
14. Djabali, M. et al. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nature Genet. 2, 113-118 (1992).
15. Golemis, E.A., Gyuris, J. & Brent, R. Interaction trap/two-hybrid system to indentify interacting proteins. Current Protocols in Molecular Biology supple. 27 (Ausbel, F.M. et al.) 1-14 (Greene Publishing Associates and Wiley-Interscience, New York, 1990).
16. Weinert, T. DNA damage and checkpoint pathways: molecular anatomy and interactions with repair. Cell 94, 555-558 (1998).
17. Paulovich, A.G. & Hartwell, L.H. A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell 82, 841-847 (1995).
18. Gottschling, D.E., Aparicio, O.M., Billington, B.L. & Zakian, V.A. Position effect at S. cerevisiae telomeres: reversible repression of PolII transcription. Cell 63, 751-762 (1990).
19. Palladino, F. et al. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell 75, 543-555 (1993).
20. Adams, A.K. & Hom, C. Specific DNA replication mutants affect telomere length in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 4614-4620 (1996).
21. Wotton, D. & Shore, D. A novel Rap1-interacting factor, Rif2p, cooperates with Rif1p to regulate length in Saccharomyces cerevisiae. Genes Dev. 11, 748-760 (1997).
22. Kyrion, G., Boakye, K.A. & Lustig, A.J. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol. Cell. Biol. 12, 5159-5173 (1992).
23. Dahlen, M., Olsson, T., Kanter-Smoler, G., Ramme, A. & Sunnerhagen, P. Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe. Mol. Biol. Cell 9, 611-621(1998).
24. Marcand, S., Gilson, E. & Shore, D. A protein-counting mechanism for telomere length regulation in yeast. Science 275, 986-990 (1997).
25. Shore, O. Telomeres - unsticky ends. Science 281, 1818-1819 (1998).
26. Cardoso, C. et al. Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein. Hum. Mol. Genet. 7, 679-684 (1998).
27. Rozenblatt-Rosen, O. et al. The C-terminal SET domain of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex. Proc. Natl. Acad. Sci. USA 95, 4152-4157 (1998).
28. Cui, X. et al. Association of SET domain and myotubularin-related proteins modulates growth control. Nature Genet. 18, 331-337 (1998).
29. Fairhead, C., Llorente B., Denis, F., Soler, M. & Dujon, B. New vectors for combinatorial deletions in yeast chromosomes and for gap-repair using split-marker recombination. Yeast 12, 1439-1457 (1996).
30. Cockell, M. et al. The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. J. Cell Biol. 129, 909-924 (1995).