Protection of telomeres by the Ku protein in fission yeast

Molecular Biology of the Cell

Volumn 11, Issue 10, 2000, Pages 3265-3275

  Baumann, P ^a   Cech, T R ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TELOMERASE;

ARTICLE; CHROMOSOME REARRANGEMENT; CHROMOSOME STRUCTURE; DNA DEGRADATION; DNA REPAIR; FUNGUS GROWTH; GENETIC CONSERVATION; GENETIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE; SENESCENCE; TELOMERE; TEMPERATURE SENSITIVITY;

SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

EID: 0033783039     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.11.10.3265     Document Type: Article

References (53)

1. The function of DNA polymerase alpha at telomeric G tails is important for telomere homeostasis
2. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
3. DNA double-strand-break sensitivity. DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae
4. Ku binds telomeric DNA in vitro
5. Structure and function of telomeres
6. Extension of life-span by introduction of telomerase into normal human cells
7. Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomeric maintenance
8. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways
9. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
10. Telomerase and the maintenance of chromosome ends
11. Telomere elongation in immortal human cells without detectable telomerase activity
12. Molecular cloning and characterization of the Schizosaccharomyces pombe his3 gene for use as a selectable marker
13. Genomic sequencing
14. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta
15. Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids
16. Telomerase, Ku, and telomeric silencing in Saccharomyces cerevisiae
17. Detection and characterization of a ring chromosome in the fission yeast Schizosaccharomyces pombe
18. Ku, a DNA repair protein with multiple cellular functions?
19. A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae
20. Subtelomeric repeat amplification is associated with growth at elevated temperature in yku70 mutants of Saccharomyces cerevisiae
21. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
22. Yeast Ku as a regulator of chromosomal DNA end structure
23. Telomere length regulation
24. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
25. Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA
26. Ku is associated with the telomere in mammals
27. Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres
28. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
29. A novel mechanism for telomere size control in Saccharomyces cerevisiae
30. Reverse transcriptase motifs in the catalytic subunit of telomerase
31. An alternative pathway for yeast telomere maintenance rescues est1-senescence
32. A mutant with a defect in telomere elongation leads to senescence in yeast
33. Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
34. Mechanism of interaction between Ku protein and DNA
35. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues
36. Reversing time: Origin of telomerase
37. Two modes of survival of fission yeast without telomerase
38. Telomerase catalytic subunit homologs from fission yeast and human
39. Telomere maintenance is dependent on activities required for end repair of double-strand breaks
40. The telomerase reverse transcriptase: Components and regulation
41. Telomerases
42. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities
43. The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae
44. Synthesis of the telomeric C-strand
45. Immortalized ceils with no detectable telomerase activity
46. TLC1 template RNA component of Saccharomyces cerevisiae telomerase
47. The DNA-dependent protein kinase
48. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
49. Control of telomere length by the human telomeric protein TRF1
50. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae
51. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs