Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

Molecular and Cellular Biology

Volumn 20, Issue 15, 2000, Pages 5712-5721

  Filippa, Nathalie ^a   Sable, Carol L ^a   Hemmings, Brian A ^b   Van Obberghen, Emmanuel ^a  

^a INSERM   (France)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PHOSPHATIDYLINOSITIDE; PROTEIN KINASE; PROTEIN KINASE B;

ARTICLE; CELL CULTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BIOLOGICAL TRANSPORT; CELL LINE; CELL MEMBRANE; ENZYME ACTIVATION; HUMANS; INSULIN; MICROSCOPY, CONFOCAL; MUTATION; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT PROTEINS; SUBCELLULAR FRACTIONS;

EID: 0033912843     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.15.5712-5721.2000     Document Type: Article

References (25)

1. Ahmed, N. N., H. L. Grimes, A. Bellacosa, T. O. Chan, and P. N. Tsichlis. 1997. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl. Acad. Sci. USA 94:3627-3632.
2. Alessi, D., and P. Cohen. 1998. Mechanism of activation and function of protein kinase B. Curr. Opin. Genet. Dev. 8:55-62.
3. Alessi, D., M. T. Kozlowski, Q.-P. Weng, N. Morrice, and J. Avruch. 1997. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr. Biol. 8:69-81.
4. Alessi, D. R., M. Deak, A. Casamayor, F. B. Caudwell, M. Morrice, D. G. Norman, P. Gaffney, C. B. Reese, C. N. MacDougall, D. Harbison, A. Ashworth, and M. Bownes. 1997. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol. 7:776-789.
5. Alessi, D. R., S. R. James, C. P. Downes, A. B. Holmes, P. R. J. Gaffney, C. B. Reese, and P. Cohen. 1997. Characterization of a 3-phosphoinositide-dependent kinase which phosphorylates and activates protein kinase Bα. Curr. Biol. 7:261-269.
6. Anderson, K. E., J. Coadwell, L. R. Stephens, and P. T. Hawkins. 1998. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr. Biol. 8:684-691.
7. Andjelkovic, M., D. Alessi, R. Meier, A. Fernandez, N. Lamb, M. Frech, P. Cron, P. Cohen, J. Lucocq, and B. Hemmings. 1997. Role of translocation in the activation and function of protein kinase B. J. Biol. Chem. 272:31515-31524.
8. Andjelkovic, M., T. Jakubowicz, P. Cron, X.-F. Ming, J.-W. Han, and B. A. Hemmings. 1996. Activation and phosphorylation of a pleckstrin holology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc. Natl. Acad. Sci. USA 93:5699-5704.
9. Burgering, T., M. Boudewijn, and P. J. Coffer. 1995. Protein kinase B (c-Akt) in phosphotidylinositol-3-OH kinase signal transduction. Nature 376:599-602.
10. Cheng, J. Q., A. K. Godwin, A. Bellacosa, T. Taguchi, T. F. Franke, T. C. Hamilton, P. N. Tsichlis, and J. R. Testa. 1992. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases is amplified in human ovarian carcinomas. Proc. Natl. Acad. Sci. USA 89:9267-9271.
11. Cheng, J. Q., B. Ruggeri, W. M. Klein, G. Sonoda, D. A. Altomare, D. K. Watson, and J. R. Testa. 1996. Amplification of AKT2 in human pancreatic-cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc. Natl. Acad. Sci. USA 93:3636-3641.
12. Cross, D. A. E., D. R. Alessi, P. Cohen, M. Andjelkovich, and B. A. Hemmings. 1995. Inhibition of glycogen synthetase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789.
13. Currie, R. A., K. S. Walker, A. Gray, M. Deak, A. Casamayor, C. P. Downes, P. Cohen, D. R. Alessi, and J. Lucocq. 1999. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem. J. 337:575-583.
14. Filippa, N., C. L. Sable, C. Filloux, B. A. Hemmings, and E. Van Obberghen. 1999. Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase. Mol. Cell. Biol. 19:4989-5000.
15. Franke, T. F., S.-I. Yang, T. O. Chan, K. Datta, A. Kazlauskas, D. K. Morrison, D. R. Kaplan, and P. N. Tsichlis. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinosital 3-kinase. Cell 81:727-736.
16. Frech, M., M. Andjelkovic, E. Ingley, K. K. Reddy, J. R. Falck, and B. A. Hemmings. 1997. High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J. Biol. Chem. 272:8474-8481.
17. Göransson, O., J. Wijkander, V. Manganiello, and E. Degerman. 1998. Insulin-induced translocation of protein kinase B to the plasma membrane in rat adipocytes. Biophys. Biochem. Res. Commun. 246:249-254.
18. Kohn, A. D., K. S. Kovacina, and R. A. Roth. 1995. Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing Ser/thr kinase. EMBO J. 14:4288-4295.
19. Li, Z., M. Wahl, A. Eguinoa, L. Stephens, P. Hawkins, and O. Witte. 1997. Proc. Natl. Acad. Sci. USA 94:13820-13825.
20. Pullen, N., P. Dennis, M. Andjelkovic, A. Dufner, S. Kozma, B. Hemmings, and G. Thomas. 1998. Phosphorylation and activation of p70s6k by PDK1. Science 279:707-710.
21. Sable, C. L., N. Filippa, C. Filloux, B. A. Hemmings, and E. Van Obberghen. 1998. Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B. J. Biol. Chem. 273:29600-29606.
22. Stephens, L., K. Anderson, D. Stokoe, H. Erdjument-Bromage, G. Painter, A. Holmes, P. Gaffney, C. Reese, F. McCormick, P. Tempst, J. Coadwell, and P. Hawkins. 1998. Protein kinase B kinase that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 279: 710-714.
23. Stokoe, D., L. R. Stephens, T. Copeland, P. R. J. Gaffney, C. B. Reese, G. F. Painter, A. B. Holmes, F. McCormick, and P. T. Hawkins. 1997. Duel role of phosphatidylinositol-3,4,5,-trisphosphate in the activation of protein kinase B. Science 277:567-570.
24. Walker, K., M. Deak, A. Paterson, K. Hudson, P. Cohen, and D. Alessi. 1998. Activation of protein kinase B beta and gamma isoforms by insulin and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B. Biochem. J. 331:299-308.
25. Wijkander, J., L. Stenson-Holst, T. Rahn, S. Resjo, I. Castan, V. Manganiello, P. Belfrage, and E. Degerman. 1997. Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxyvanadate. J. Biol. Chem. 272:21520-21526.