The dynamics of protein kinase B regulation during B cell antigen receptor engagement

Journal of Cell Biology

Volumn 145, Issue 7, 1999, Pages 1511-1520

  Astoul, Emmanuelle ^a   Watton, Sandra ^a   Cantrell, Doreen ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Akt PKB; B cell antigen receptor; Fc RIIb; GSK3; Phosphatidylinositol 3 kinase

Indexed keywords

B LYMPHOCYTE ANTIGEN; GREEN FLUORESCENT PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL FUNCTION; CELL MEMBRANE; CYTOSOL; ENZYME LOCALIZATION; ENZYME REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, CD; B-LYMPHOCYTES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL MEMBRANE; CELL NUCLEUS; CYTOSOL; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR AGGREGATION; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, IGG; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033612540     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.145.7.1511     Document Type: Article

References (46)

1. Alessi, D., and P. Cohen. 1998. Mechanism of activation and function of protein-kinase-B. Curr. Opin. Genet. Dev. 8:55-62.
2. Alessi, D.R., S.R. James, C.P. Downes, A.B. Holmes, P.R. Gaffney, C.B. Reese, and P. Cohen. 1997. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr. Biol. 7:261-269.
3. Aman, M.J., T.D. Lamkin, H. Okada, T. Kurosaki, and S. Ravichandran. 1998. The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells. J. Biol. Chem. 273:33922-33928.
4. andjelkovic, M., D.R. Alessi, R. Meier, A. Fernandez, N.J. Lamb, M. Fiech, P. Cron, P. Cohen, J.M. Lucocq, B.A. Hemmings. 1997. Role of translocation in the activation and function of PKB. J. Biol. Chem. 272:31515-31524.
5. Beals, C.R., C.M. Sheridan, C.W. Turck, P. Gardner, and G. Crabtree. 1997. Nuclear export of NFATc enhanced by glycogen synthase kinase-3. Science. 275:1930-1933.
6. Bellacosa, A., T.O. Chan, N.N. Ahmed, K. Datta, S. Malstrom, D. Stokoe, F. McCormick, J. Feng, and P. Tsichlis. 1998. Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene. 17:313-325.
7. Holland, S., R.N. Pearse, T. Kurosaki, and J.V. Ravetch. 1998. SHIP modulates immune receptor responses by regulating membrane association of Btk. Immunity. 8:509.
8. Brennan, P., J.W. Babbage, B.M.T. Burgering, B. Groner, K. Reif, and D.A. Cantrell. 1997. Phosphatidylinositol 3-kinase controls E2F transcriptional activity in response to interleukin-2. Immunity. 7:679-689.
9. Burshtyn, D., and E. Long. 1997. Regulation through inhibitory receptors: lessons from natural-killer cells. Trends Cell Biol. 7:473-479.
10. Cambier, J.C., and W.A. Jensen. 1994. The hetero-oligomeric antigen receptor complex and its coupling to cytoplasmic effectors. Curr. Biol. 4:55-63.
11. Cross, D.A., D.R. Alessi, P. Cohen, M. Andjelkovic, and B.A. Hemmings. 1995. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 378:785-789.
12. DeFranco, A.L. 1997. Molecular mechanisms in B cell antigen receptor signaling. Curr. Opin. Immunol. 9:309.
13. Desiderio, S., and J.D. Siliciano. 1994. The Itk/Btk/Tec family of protein-tyrosine kinases. Chem. Immunol. 59:191-210.
14. Franke, F.T., S. Yang, O.T. Chan, K. Datta, A. Kazlauskas, K.D. Morrison, R.D. Kalpan, and N.P. Tsichlis. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell. 81:727-736.
15. Franke, T.F., D.R. Kaplan, L.C. Cantley, and A. Toker. 1997. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science. 275:665-668.
16. Frech, M., M. Andjelkovic, E. Ingley, K.K. Reddy, J.R. Falck, and B.A. Hemmings. 1997. High-affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of rac protein-kinase-B and their influence on kinase-activity. J. Biol. Chem. 272:8474-8481.
17. Fruman, D., S. Snapper, C. Yballe, L. Davidson, J. Yu, F. Alt, and L. Cantley. 1999. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85. Science. 283:393-397.
18. Gold, M.R., V.W. Chan, C.W. Turck, and A.L. DeFranco. 1992. Membrane Ig cross-linking regulates phosphatidylinosilol 3-kinase in B lymphocytes. J. Immunol. 148:2012-2022.
19. Heim, R., and R.Y. Tsien. 1996. Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer. Curr. Biol. 6:178-182.
20. Helgason, C., J. Damen, P. Rosten, R. Grewal, P. Sorensen, S. Chappel, A. Borowski, F. Jirik, G. Krystal, and R. Humphries. 1998. Targeted disruption of Ship leads to hematopoietic perturbations lung pathology, and a shortened life-span. Genes Dev. 12:1610-1620.
21. Hippen, K.L., A.M. Buhl, D. D'Ambrosia, K. Nakamura, C. Persin, and J.C. Gambier. 1997. FcγRIIb inhibition of BCR mediated phosphoinositide hydrolysis and calcium mobilization is integrated by CD19 dephosphorylation. Immunity. 7:49-58.
22. Jacob, A., D. Cooney, S. Tridandapani, T. Kelly, and K.M. Coggeshall. 1999. FcγRIIB modulation of surface immunoglobulin induced AKT activation in murine B cells. J. Biol. Chem. 274:13704-13710.
23. Kauffmann-Zeh, A., P. Rodriguez-Viciana, E. Ulrich, C. Gilbert, P. Coffer, J. Downward, and G. Evan. 1997. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature. 385:544-548.
24. Klippel, A., W.M. Kavanaugh, D. Pot, and L.T. Williams. 1997. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol. Cell. Biol. 17:338-344.
25. Kulik, G., A. Klippel, and M.J. Weber. 1997. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17:1595-1606.
26. Meier, R., D.R. Alesssi, P. Cron, M. Andjelkovic, and B.A. Hemmings. 1997. Mitogenic activation, phosphorylation and nuclear translocation of protein kinase Bβ. J. Biol. Chem. 272:30491-30497.
27. Meier, R., M. Thelen, and B.A. Hemmings. 1998. Inactivation and dephosphorylation of protein kinase Ba (PKBα) promoted by hyperosmotic stress. EMBO (Eur. Mol. Biol. Organ.) J. 17:7294-7303.
28. 2+ oscillatory response. J. Immunol. 161:5129-5132.
29. Ono, M., H. Okada, S. Bolland, S. Yanagi, T. Kurosaki, and J.V. Ravetch. 1997. Deletion of SHIP of SHP-1 reveals two distinct pathways for inhibitory signaling. Cell. 90:293.
30. Rameh, L.E., A.-K. Arvidsson, K.L. Carraway III, A.D. Couvillon, G. Rathbun, A. Crompton, B. VanRenterghem, M.P. Czech, K.S. Ravichandran, S.J. Burakoff, et al. 1997. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J. Biol. Chem. 272:22059-22066.
31. Rawlings, D.J., A.M. Scharenberg, H. Park, M.I. Wahl, S. Lin, R.M. Kato, A.C. Fluckiger, O.N. Witte, and J.P. Kinet. 1996. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science. 271:822-825.
32. Reif, K., B.M.T. Burgering, and D.A. Cantrell. 1997. Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase. J. Biol. Chem. 272:14426-14438.
33. Reif, K., C.D. Nobes, G. Thomas, A. Hall, and D.A. Cantrell. 1996. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6:1445-1455.
34. Rizzuto, R., M. Brini, F. De Giorgi, R. Rossi, R. Heim, R.Y. Tsien, and T. Pozzan. 1996. Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo. Curr. Biol. 6:183-188.
35. Rubinfeld, B., I. Albert, E. Porfiri, C. Fiol. S. Munemitsu, and P. Polakis. 1996. Binding of GSK3-beta to the APC-beta-catenin complex and regulation of complex assembly. Science. 272:1023-1026.
36. Sarao, R., I. Kozieradzki, P. Ohashi, J. Penninger, and D. Dumont. 1998. The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B-cell antigen receptor signaling. J. Exp. Med. 188:1333-1342.
37. Scharenberg, A., O. Elhillal, D. Fruman, L. Beitz, Z. Li, S. Lin, I. Gout, L. Cantley, D. Rawlings, and J. Kinet. 1998. Phosphatidylinositol-3,4,5-trisphosphate (Ptdins-3,4,5-P-3) Tec kinase-dependent calcium signaling pathway: a target for Ship-mediated inhibitory signals. EMBO (Eur. Mol. Biol. Organ.) J. 17:1961-1972.
38. Scharenberg, A.M., and J.P. Kinet. 1998. PtdIns-3, 4, 5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals. Cell. 94:5.
39. Staal, S.P., and J.W. Hartley. 1988. Thymic lymphoma induction by the AKT8 murine retrovirus. J. Exp. Med. 167:1259-1264.
40. Stephens, L., K. Anderson, D. Stokoe, H. Erdjument-Bromage, G.F. Painter, A.B. Holmes, P.R.J. Gaffney, C.B. Reese, F. McCormick, P. Tempst, J. Coadwell, and P.T. Hawkins. 1998. Protein-kinase-B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein-kinase-b. Science. 279:710-714.
41. Suzuki, H., Y. Terauchi, M. Fujiwara, S. Aizawa, Y. Yazaki, T. Kadowaki, and Y. Koyasu. 1999. Xid-like immunodeficiency in mice with disruption of the p85 subunit of phosphoinositide 3-kinase. Science. 283:390-392.
42. Takai, T., M. Ono, M. Hikida, H. Ohmori, and J.V. Ravetch. 1996. Augmented humoral and anaphylactic responses in FcγRII-deficient mice. Nature. 379:346.
43. Tridandapani, S., T. Kelley, M. Pradhan, D. Cooney, L. Justement, and K. Coggeshall. 1997. Recruitment and phosphorylation of SH2-containing inositol phosphatase and She to the B-cell Fc-gamma immunoreceptor tyrosine-based inhibition motif peptide motif. Mol. Cell. Biol. 17:4305-4311.
44. Watton, S., and J. Downward. 1999. Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction. Curr. Biol. 9:433-436.
45. Yamanashi, Y., Y. Fukui, B. Wongsasant, Y. Kinoshita, Y. Ichimori, K. Toyoshima, and T. Yamamoto. 1992. Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling. Proc. Natl. Acad. Sci. USA. 89: 1118-1122.
46. Zha, J., H. Harada, E. Yang, J. Jockel, and S.J. Korsmeyer. 1996. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell. 87:619-628.