Lipid phosphatases in the immune system

Seminars in Immunology

Volumn 12, Issue 4, 2000, Pages 397-403

  Krystal, Gerald ^a  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

Apoptosis; Proliferation; PTEN; SHIP; SHIP2

Indexed keywords

PHOSPHATASE;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVITY; HUMAN; IMMUNE SYSTEM; SIGNAL TRANSDUCTION;

EID: 0033804532     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.2000.0222     Document Type: Article

References (65)

1. Lipid second messengers
2. First thoughts on lipid second messengers
3. Phospholipid signaling
4. Phosphoinositides as regulators in membrane traffic
5. The study of phosphoinositide 3-kinase function
6. The diversity and possible functions of the inositol polyphosphate 5-phosphatases
7. The role of phosphoinositide 3-kinase lipid products in cell function
8. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways
9. Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes
10. The role of phosphatases in inositol signaling reactions
11. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
12. p150(Ship), a signal transduction molecule with inositol polyphosphate-5-phosphatase activity
13. Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
14. The SH2-containing inositol polyphosphatase 5-phosphatase. SHIP, is expressed during hematopoiesis and spermatogenesis
15. The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood
16. A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: Aberrant development and enhanced function of B lymphocytes in SHIP(-/-) mice
17. The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors
18. Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation
19. Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl
20. A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development
21. The SH2 domain of SHIP is essential for SHIP's tyrosine phosphorylation, its association with Shc and its induction of apoptosis
22. Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2
23. The Src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes
24. Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc
25. The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation
26. Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs
27. Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene
28. Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31
29. The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptor
30. The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis
31. CDw150 associates with Src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis
32. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology and a shortened lifespan
33. The inositol polyphosphate 5-phosphatase Ship is a crucial negative regulator of B cell antigen receptor signaling
34. A lethal myeloproliferatiw: Syndrome in mice transplanted with bone marrow cells infected with a retrosvirus expressing granulocyte-macrophage colony stimulating factor
35. The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation
36. Targeted disruption of SHIP leads to steel factor induced degranulation of mast cells
37. The role of the SRC homology 2-containing inositol 5'-phosphatase in FcεR1-induced signaling
38. Regulation of mast cell degranulation by SHIP
39. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc-gamma-RIIB
40. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling
41. SHIP modulates immune receptor responses by regulating membrane association of Btk
42. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
43. The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells
44. Fcγ/RIIb modulation of surface immunoglobulin-induced Akt activation in murine B cells
45. Inhibitory signaling by B cell FcγRIIb
46. Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors
47. Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP
48. A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells
49. The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity
50. Distribution of the Src-homology-2-domain-containing inositol 5-phosphatase SHIP-2 in both non-haemopoietic and haemopoietic cells and possible involvement of SHIP-2 in negative signalling of B-cell
51. The two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytes
52. Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein
53. Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling
54. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
55. Identification of a candidate tumour suppressor gene. MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
56. TEP1, encoded by a candidate tumor suppressor locus, is a novel promin tyrosine phosphatase regulated by transforming growth factor β
57. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
58. Tensin: A potential link between the cytoskeleton and signal transduction
59. Role of auxilin in uncoating clathrin-coated vesicles
60. Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: Differential involvement of focal adhesion kinase and p130(Cas)
61. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
62. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
63. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
64. PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1