-
1
-
-
0030892234
-
Apoptosis by Death Factor
-
Nagata, S., Apoptosis by Death Factor. Cell 1997. 88: 355-365.
-
(1997)
Cell
, vol.88
, pp. 355-365
-
-
Nagata, S.1
-
3
-
-
0029995766
-
A license to kill
-
Fraser, A. and Evan, G., A license to kill. Cell 1996. 85: 781-784.
-
(1996)
Cell
, vol.85
, pp. 781-784
-
-
Fraser, A.1
Evan, G.2
-
4
-
-
0029066697
-
Contenders in FasL/TNF Death signaling
-
Cleveland, J. L. and Ihle, J. N., Contenders in FasL/TNF Death signaling. Cell 1995. 81: 479-482.
-
(1995)
Cell
, vol.81
, pp. 479-482
-
-
Cleveland, J.L.1
Ihle, J.N.2
-
5
-
-
0028883850
-
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
-
Kischkel, F. C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P. H. and Peter, M. E., Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 1995. 14: 5579-5588.
-
(1995)
EMBO J.
, vol.14
, pp. 5579-5588
-
-
Kischkel, F.C.1
Hellbardt, S.2
Behrmann, I.3
Germer, M.4
Pawlita, M.5
Krammer, P.H.6
Peter, M.E.7
-
6
-
-
0030925774
-
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
-
Medema, J. P., Scaffidi, C., Kischkel, F. C., Shevchenko, A., Mann, M., Krammer, P. H. and Peter, M. E., FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J. 1997. 16: 2794-2804.
-
(1997)
EMBO J.
, vol.16
, pp. 2794-2804
-
-
Medema, J.P.1
Scaffidi, C.2
Kischkel, F.C.3
Shevchenko, A.4
Mann, M.5
Krammer, P.H.6
Peter, M.E.7
-
7
-
-
0029026548
-
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
-
Chinnaiyan, A. M., O'Rourke, K., Tewari, M. and Dixit, V. M., FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995. 81: 505-512.
-
(1995)
Cell
, vol.81
, pp. 505-512
-
-
Chinnaiyan, A.M.1
O'Rourke, K.2
Tewari, M.3
Dixit, V.M.4
-
8
-
-
0028913550
-
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
-
Boldin, M. P., Varfolomeev, E. E., Pancer, Z., Mett, I. L., Camonis, J. H. and Wallach, D., A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J. Biol. Chem. 1995. 270: 7795-7798.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7795-7798
-
-
Boldin, M.P.1
Varfolomeev, E.E.2
Pancer, Z.3
Mett, I.L.4
Camonis, J.H.5
Wallach, D.6
-
9
-
-
15844412409
-
FLICE, a novel FADD-homologous ICE/CED-3-like Protease, is recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
-
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., Mann, M., Krammer, P. H., Peter, M. E. and Dixit, V. M., FLICE, a novel FADD-homologous ICE/CED-3-like Protease, is recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex. Cell 1996. 85: 817-827.
-
(1996)
Cell
, vol.85
, pp. 817-827
-
-
Muzio, M.1
Chinnaiyan, A.M.2
Kischkel, F.C.3
O'Rourke, K.4
Shevchenko, A.5
Ni, J.6
Scaffidi, C.7
Bretz, J.D.8
Zhang, M.9
Gentz, R.10
Mann, M.11
Krammer, P.H.12
Peter, M.E.13
Dixit, V.M.14
-
10
-
-
0030011398
-
Involvement of MACH, a novel MORT1/FADD-interacting Protease, in Fas/APO-1 and TNF Receptor-Induced Cell Death
-
Boldin, M. P., Goncharov, T. M., Goltsev, Y. V. and Wallach, D., Involvement of MACH, a novel MORT1/FADD-interacting Protease, in Fas/APO-1 and TNF Receptor-Induced Cell Death. Cell 1996. 85: 803-815.
-
(1996)
Cell
, vol.85
, pp. 803-815
-
-
Boldin, M.P.1
Goncharov, T.M.2
Goltsev, Y.V.3
Wallach, D.4
-
11
-
-
0009530192
-
Human ICE/CED-3 Protease Nomenclature
-
Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G., Thornberry, N. A., Wong, W. W. and Yuan, J., Human ICE/CED-3 Protease Nomenclature. Cell 1996. 87: 171.
-
(1996)
Cell
, vol.87
, pp. 171
-
-
Alnemri, E.S.1
Livingston, D.J.2
Nicholson, D.W.3
Salvesen, G.4
Thornberry, N.A.5
Wong, W.W.6
Yuan, J.7
-
12
-
-
0029125701
-
Protease activation during apoptosis: Death by a thousands cuts?
-
Martin, S. J. and Green, D. R., Protease activation during apoptosis: death by a thousands cuts? Cell 1995. 82: 349-352.
-
(1995)
Cell
, vol.82
, pp. 349-352
-
-
Martin, S.J.1
Green, D.R.2
-
13
-
-
0029794385
-
The ICE family of cysteine proteases as effectors of cell death
-
Kumar, S. and Lavin, M. F., The ICE family of cysteine proteases as effectors of cell death. Cell Death Differ. 1996. 3: 255-267.
-
(1996)
Cell Death Differ.
, vol.3
, pp. 255-267
-
-
Kumar, S.1
Lavin, M.F.2
-
14
-
-
0030473287
-
Sphingomyelin breakdown and cell fate
-
Testi, R., Sphingomyelin breakdown and cell fate. Trends Biochem. Sci. 1996. 21: 468-471.
-
(1996)
Trends Biochem. Sci.
, vol.21
, pp. 468-471
-
-
Testi, R.1
-
15
-
-
0030024114
-
Fas-mediated apoptosis and sphingomyelinase signal transduction: The role of ceramide as a second messenger for apoptosis
-
Skowronski, E. W., Kolesnick, R. N. and Green, D. R., Fas-mediated apoptosis and sphingomyelinase signal transduction: the role of ceramide as a second messenger for apoptosis. Cell Death Differ. 1996. 3: 171-176.
-
(1996)
Cell Death Differ.
, vol.3
, pp. 171-176
-
-
Skowronski, E.W.1
Kolesnick, R.N.2
Green, D.R.3
-
16
-
-
0030448021
-
Functions of Ceramide in coordinating cellular responses to stress
-
Hannun, J. A., Functions of Ceramide in coordinating cellular responses to stress. Science 1996. 274: 1855-1859.
-
(1996)
Science
, vol.274
, pp. 1855-1859
-
-
Hannun, J.A.1
-
17
-
-
0028670382
-
The role of APO-1 mediated apoptosis in the immune system
-
Krammer, P. H., Dhein, Y., Valczak, H., Behrmann, I., Mariani, S., Matiba, B., Fath, M., Daniel, P. T., Knipping, E., Westendorp, M. O., Stricker, K., Baumler, C., Hellbardt, S., Germer, M., Peter, M. E. and Debatin, K.-M., The role of APO-1 mediated apoptosis in the immune system. Immunol. Rev. 1994. 142: 175-191.
-
(1994)
Immunol. Rev.
, vol.142
, pp. 175-191
-
-
Krammer, P.H.1
Dhein, Y.2
Valczak, H.3
Behrmann, I.4
Mariani, S.5
Matiba, B.6
Fath, M.7
Daniel, P.T.8
Knipping, E.9
Westendorp, M.O.10
Stricker, K.11
Baumler, C.12
Hellbardt, S.13
Germer, M.14
Peter, M.E.15
Debatin, K.-M.16
-
18
-
-
0028927607
-
The Fas death factor
-
Nagata, S. and Golstein, P., The Fas death factor. Science 1995. 267: 1449-1456.
-
(1995)
Science
, vol.267
, pp. 1449-1456
-
-
Nagata, S.1
Golstein, P.2
-
19
-
-
0030025995
-
Involvement of Fas in regression of vaginal epithelia after ovariectomy and during an estrous cycle
-
Suzuki, A., Enari, M., Eguchi, Y., Matsuzawa, A., Nagata, S., Tsujimoto, Y. and Iguchi, T., Involvement of Fas in regression of vaginal epithelia after ovariectomy and during an estrous cycle. EMBO J. 1996. 15: 211-215.
-
(1996)
EMBO J.
, vol.15
, pp. 211-215
-
-
Suzuki, A.1
Enari, M.2
Eguchi, Y.3
Matsuzawa, A.4
Nagata, S.5
Tsujimoto, Y.6
Iguchi, T.7
-
20
-
-
0031034933
-
Potential involvement of Fas and its Ligand in the pathogenesis of Hashimoto's Thyroiditis
-
Giordano, C., Stassi, G., De Maria, R., Todaro, M., Richiusa, P., Papoff, G., Ruberti, G., Bagnasco, M., Testi, R. and Galluzzi, A., Potential involvement of Fas and its Ligand in the pathogenesis of Hashimoto's Thyroiditis. Science 1997. 275: 960-963.
-
(1997)
Science
, vol.275
, pp. 960-963
-
-
Giordano, C.1
Stassi, G.2
De Maria, R.3
Todaro, M.4
Richiusa, P.5
Papoff, G.6
Ruberti, G.7
Bagnasco, M.8
Testi, R.9
Galluzzi, A.10
-
21
-
-
0026524523
-
DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement
-
Owen-Schaub, L. B., Yonehara, S., Crump, W. L. and Grimm, E. A., DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cell. Immunol. 1992. 140: 197-205.
-
(1992)
Cell. Immunol.
, vol.140
, pp. 197-205
-
-
Owen-Schaub, L.B.1
Yonehara, S.2
Crump, W.L.3
Grimm, E.A.4
-
22
-
-
0027183703
-
Activation interferes with the APO-1 pathways in mature human T cells
-
Klas, C., Debatin, K.-M., Jonker, R. R. and Krammer, P. H., Activation interferes with the APO-1 pathways in mature human T cells. Int. Immunol. 1993. 5: 625-630.
-
(1993)
Int. Immunol.
, vol.5
, pp. 625-630
-
-
Klas, C.1
Debatin, K.-M.2
Jonker, R.R.3
Krammer, P.H.4
-
23
-
-
0028837554
-
CD28 and apoptosis
-
Boise, L. H., Noel, P. J. and Thompson, C. B., CD28 and apoptosis. Curr. Opin. Immunol. 1995. 7: 620-625.
-
(1995)
Curr. Opin. Immunol.
, vol.7
, pp. 620-625
-
-
Boise, L.H.1
Noel, P.J.2
Thompson, C.B.3
-
24
-
-
0030266548
-
IL-4 induces Fas resistance in B cells
-
Foote, L. C., Howard, R. G., Marshak-Rothstein, A. and Rothstein, T. L., IL-4 induces Fas resistance in B cells. J. Immunol. 1996. 157: 2749-2753.
-
(1996)
J. Immunol.
, vol.157
, pp. 2749-2753
-
-
Foote, L.C.1
Howard, R.G.2
Marshak-Rothstein, A.3
Rothstein, T.L.4
-
26
-
-
0028963084
-
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
-
Yao, R. and Cooper, G. M., Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 1995. 267: 2003-2006.
-
(1995)
Science
, vol.267
, pp. 2003-2006
-
-
Yao, R.1
Cooper, G.M.2
-
27
-
-
0030026693
-
Requirement for phosphatidylinositol 3′-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor
-
Minshall, C., Arkins, S., Freund, G. G. and Kelley, K. W., Requirement for phosphatidylinositol 3′-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor. J. Immunol. 1996. 156: 939-947.
-
(1996)
J. Immunol.
, vol.156
, pp. 939-947
-
-
Minshall, C.1
Arkins, S.2
Freund, G.G.3
Kelley, K.W.4
-
28
-
-
0031014651
-
Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways
-
Parrizas, M., Saltiel, A. R. and LeRoith, D., Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J. Biol. Chem. 1997. 272: 154-161.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 154-161
-
-
Parrizas, M.1
Saltiel, A.R.2
LeRoith, D.3
-
29
-
-
0028834557
-
Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: Phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signaling between interleukin-3 and granulocyte-macrophage colony stimulating factor
-
Scheid, M. P., Lauener, R. W. and Duronio, V., Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signaling between interleukin-3 and granulocyte-macrophage colony stimulating factor. Biochem. J. 1995. 312: 159-162.
-
(1995)
Biochem. J.
, vol.312
, pp. 159-162
-
-
Scheid, M.P.1
Lauener, R.W.2
Duronio, V.3
-
30
-
-
0030907987
-
PI3K: Downstream AKTion blocks apoptosis
-
Franke, T. F., Kaplan, D. R. and Cantley, L. C., PI3K: downstream AKTion blocks apoptosis. Cell 1997. 88: 435-437.
-
(1997)
Cell
, vol.88
, pp. 435-437
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
-
31
-
-
0031028730
-
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
-
Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J. and Evan, G., Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 1997. 385: 544-548.
-
(1997)
Nature
, vol.385
, pp. 544-548
-
-
Kauffmann-Zeh, A.1
Rodriguez-Viciana, P.2
Ulrich, E.3
Gilbert, C.4
Coffer, P.5
Downward, J.6
Evan, G.7
-
32
-
-
0029048498
-
Life and death during lymphocyte development and function: Evidence for two distinct killing mechanisms
-
Strasser, A., Life and death during lymphocyte development and function: evidence for two distinct killing mechanisms. Curr. Opin. Immunol. 1995. 7: 228-234.
-
(1995)
Curr. Opin. Immunol.
, vol.7
, pp. 228-234
-
-
Strasser, A.1
-
33
-
-
0029899181
-
Molecular Thanatopsis: A discourse on the Bcl2 family and cell death
-
Yang, E. and Korsmeyer, S. J., Molecular Thanatopsis: a discourse on the Bcl2 family and cell death. Blood 1996. 15: 386-401.
-
(1996)
Blood
, vol.15
, pp. 386-401
-
-
Yang, E.1
Korsmeyer, S.J.2
-
34
-
-
0031034563
-
Controlling cell death
-
Golstein, P., Controlling cell death. Science 1997. 275: 1081-1082.
-
(1997)
Science
, vol.275
, pp. 1081-1082
-
-
Golstein, P.1
-
35
-
-
0029118603
-
Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
-
Ui, M., Okada, T., Hazeki, K. and Hazeki, O., Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem. Sci. 1995. 20: 303-307.
-
(1995)
Trends Biochem. Sci.
, vol.20
, pp. 303-307
-
-
Ui, M.1
Okada, T.2
Hazeki, K.3
Hazeki, O.4
-
36
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos, C. J., Matter, W. F., Hui, K. Y. and Brown, R. F., A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 1994. 269: 5241-5248.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
37
-
-
0030293886
-
Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
-
Reif, K., Nobes, C. D., Thomas, G., Hall, A. and Cantrell, D. A., Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 1996. 6: 1445-1455.
-
(1996)
Curr. Biol.
, vol.6
, pp. 1445-1455
-
-
Reif, K.1
Nobes, C.D.2
Thomas, G.3
Hall, A.4
Cantrell, D.A.5
-
38
-
-
10544236916
-
Signal transduction by DR3 a death domain containing receptor related to TNFR1 and CD95
-
Chinnaiyan, A. M., O'Rourke, K., Yu, G.-L., Lyons, R. H., Garg, M., Duan, D. R., Xing, L., Gentz, R., Ni, J. and Dixit, V. M., Signal transduction by DR3 a death domain containing receptor related to TNFR1 and CD95. Science 1996. 274: 990-992.
-
(1996)
Science
, vol.274
, pp. 990-992
-
-
Chinnaiyan, A.M.1
O'Rourke, K.2
Yu, G.-L.3
Lyons, R.H.4
Garg, M.5
Duan, D.R.6
Xing, L.7
Gentz, R.8
Ni, J.9
Dixit, V.M.10
-
40
-
-
0026006501
-
Molecular-cloning and characterization of a novel putative protein-serine kinase related to the cAMP-dependent and protein-kinase-C families
-
Coffer, P. J. and Woodgett, J. R., Molecular-cloning and characterization of a novel putative protein-serine kinase related to the cAMP-dependent and protein-kinase-C families. Eur. J. Biochem. 1991. 201: 475-481.
-
(1991)
Eur. J. Biochem.
, vol.201
, pp. 475-481
-
-
Coffer, P.J.1
Woodgett, J.R.2
-
41
-
-
0025882091
-
Molecular-cloning and identification of a serine threonine protein-kinase of the 2nd-messenger subfamily
-
Jones, P. F., Jacubowicz, T., Pitossi, F. J., Maurer, F. and Hemmings, B. A., Molecular-cloning and identification of a serine threonine protein-kinase of the 2nd-messenger subfamily. Proc. Natl. Acad. Sci. USA 1991. 88: 4171-4175.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 4171-4175
-
-
Jones, P.F.1
Jacubowicz, T.2
Pitossi, F.J.3
Maurer, F.4
Hemmings, B.A.5
-
42
-
-
0026095665
-
A retroviral oncogene, AKT, encoding a serine-threonine kinase containing and SH2-like region
-
Bellacosa, A., Testa, J. R., Staal, S. P. and Tsichilis, P. N., A retroviral oncogene, AKT, encoding a serine-threonine kinase containing and SH2-like region. Science 1991. 254: 244-247.
-
(1991)
Science
, vol.254
, pp. 244-247
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichilis, P.N.4
-
43
-
-
0026659046
-
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70kdS6 protein kinase
-
Chung, J., Kuo, C. J., Crabtree, G. R. and Blenis, J., Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70kdS6 protein kinase. Cell 1992. 69: 1227-1236.
-
(1992)
Cell
, vol.69
, pp. 1227-1236
-
-
Chung, J.1
Kuo, C.J.2
Crabtree, G.R.3
Blenis, J.4
-
44
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
Burgering, B. M. and Coffer, P. J., Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 1995. 376: 599-602.
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.1
Coffer, P.J.2
-
45
-
-
0029079275
-
The protein kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R. and Tsichilis, P. N., The protein kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 1995. 81: 727-736.
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
Datta, K.4
Kazlauskas, A.5
Morrison, D.K.6
Kaplan, D.R.7
Tsichilis, P.N.8
-
46
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovic, M. and Hemmings, B. A., Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995. 378: 785-789.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.E.1
Alessi, D.R.2
Cohen, P.3
Andjelkovic, M.4
Hemmings, B.A.5
-
47
-
-
0029143388
-
Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase
-
Kohn, A. D., Kovacina, K. S. and Roth, R. A., Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J. 1995. 14: 4288-4295.
-
(1995)
EMBO J.
, vol.14
, pp. 4288-4295
-
-
Kohn, A.D.1
Kovacina, K.S.2
Roth, R.A.3
-
48
-
-
0029804116
-
Mechanism of activation of protein-kinase B by insulin and IGF-1
-
Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P. and Hemmings, B. A., Mechanism of activation of protein-kinase B by insulin and IGF-1. EMBO J. 1996. 15: 6541-6551.
-
(1996)
EMBO J.
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
50
-
-
0029943605
-
Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
-
Klippel, A., Reinhard, C., Kavanaugh, W. M., Apell, G., Escobedo, M. A. and Williams, L. T., Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell. Biol. 1996. 16: 4117-4127.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4117-4127
-
-
Klippel, A.1
Reinhard, C.2
Kavanaugh, W.M.3
Apell, G.4
Escobedo, M.A.5
Williams, L.T.6
-
51
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R. and Greenberg, M. E., Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997. 275: 661-665.
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
52
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Thompson, C. B., Apoptosis in the pathogenesis and treatment of disease. Science 1995. 267: 1456-1462.
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thompson, C.B.1
-
53
-
-
0029015694
-
A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids
-
Nakanishi, S., Catt, K. J. and Balla, T., A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids. Proc. Natl. Acad. Sci. USA 1995. 92: 5317-5321.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5317-5321
-
-
Nakanishi, S.1
Catt, K.J.2
Balla, T.3
-
54
-
-
0028850452
-
Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase
-
Cross, M. J., Stewart, A., Hodgkin, M. N., Kerr, D. J. and Wakelam, M. J., Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase. J. Biol. Chem. 1995. 270: 25352-25355.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 25352-25355
-
-
Cross, M.J.1
Stewart, A.2
Hodgkin, M.N.3
Kerr, D.J.4
Wakelam, M.J.5
-
55
-
-
0029831167
-
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002
-
Brunn, G. J., Williams, J., Sabers, C., Wiederrecht, G., Lawrence Jr, J. C. and Abraham, R. T., Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 1996. 15: 5256-5267.
-
(1996)
EMBO J.
, vol.15
, pp. 5256-5267
-
-
Brunn, G.J.1
Williams, J.2
Sabers, C.3
Wiederrecht, G.4
Lawrence Jr., J.C.5
Abraham, R.T.6
-
56
-
-
0030063193
-
Fas/Apo-1/CD95 receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis
-
Cascino, I., Papoff, G., De Maria, R., Testi, R. and Ruberti, G., Fas/Apo-1/CD95 receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis. J. Immunol. 1996. 156: 13-17.
-
(1996)
J. Immunol.
, vol.156
, pp. 13-17
-
-
Cascino, I.1
Papoff, G.2
De Maria, R.3
Testi, R.4
Ruberti, G.5
-
57
-
-
0031039024
-
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-biphosphate
-
Franke, T. F., Kaplan, D. R., Cantley, L. C. and Toker, A., Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-biphosphate. Science 1997. 275: 665-668.
-
(1997)
Science
, vol.275
, pp. 665-668
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
-
58
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
-
Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B. and Cohen, P., Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr. Biol. 1997. 7: 261-269.
-
(1997)
Curr. Biol.
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.J.5
Reese, C.B.6
Cohen, P.7
-
59
-
-
0029821721
-
Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase
-
Konishi, M., Matsuzaki, H., Tanaka, M., Ono, Y., Tokunaga, C., Kuroda, S. and Kikkawa, U., Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 1996. 93: 7639-7643.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 7639-7643
-
-
Konishi, M.1
Matsuzaki, H.2
Tanaka, M.3
Ono, Y.4
Tokunaga, C.5
Kuroda, S.6
Kikkawa, U.7
-
60
-
-
0028840004
-
Inactivation of Glycogen Synthase Kinase-3 by Epidermal Growth Factor is mediated by Mitogen-activated Protein Kinase/p90 Ribosomal Protein S6 Kinase signaling pathway in NIH/3T3 cells
-
Eldar-Finkelman, H., Seger, R., Vandenheede, J. R. and Krebs, E. G., Inactivation of Glycogen Synthase Kinase-3 by Epidermal Growth Factor is mediated by Mitogen-activated Protein Kinase/p90 Ribosomal Protein S6 Kinase signaling pathway in NIH/3T3 cells. J. Biol. Chem. 1995. 270: 987-990.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 987-990
-
-
Eldar-Finkelman, H.1
Seger, R.2
Vandenheede, J.R.3
Krebs, E.G.4
-
61
-
-
0030890234
-
Nuclear export of NF-ATc enhanced by Glycogen Synthase Kinase-3
-
Beals, C. R., Sheridan, C. M., Turck, C. W., Gardner, P. and Crabtree, G. R., Nuclear export of NF-ATc enhanced by Glycogen Synthase Kinase-3. Science 1997. 275: 1930-1933.
-
(1997)
Science
, vol.275
, pp. 1930-1933
-
-
Beals, C.R.1
Sheridan, C.M.2
Turck, C.W.3
Gardner, P.4
Crabtree, G.R.5
-
62
-
-
17544374351
-
T cell activation leads to rapid stimulation of translation initiation factor IF2B and inactivation of glycogen synthase kinase-3
-
Welsh, G. I., Miyamoto, S., Price, N. T., Safer, B. and Proud, C. G., T cell activation leads to rapid stimulation of translation initiation factor IF2B and inactivation of glycogen synthase kinase-3. J. Biol. Chem. 1996. 271: 11410-11413.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 11410-11413
-
-
Welsh, G.I.1
Miyamoto, S.2
Price, N.T.3
Safer, B.4
Proud, C.G.5
-
63
-
-
0025871394
-
Nuclear association of a T-cell transcription factor blocked by FK-506 and Cyclosporin A
-
Flanagan, W. M., Corthesy, B., Bram, R. J. and Crabtree, G. R., Nuclear association of a T-cell transcription factor blocked by FK-506 and Cyclosporin A. Nature 1991. 352: 803-807.
-
(1991)
Nature
, vol.352
, pp. 803-807
-
-
Flanagan, W.M.1
Corthesy, B.2
Bram, R.J.3
Crabtree, G.R.4
-
64
-
-
0029851762
-
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
-
Timmerman, L. A., Clipstone, N. A., Ho, S. N., Northrop, J. P. and Crabtree, G. R., Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature 1996. 383: 837-840.
-
(1996)
Nature
, vol.383
, pp. 837-840
-
-
Timmerman, L.A.1
Clipstone, N.A.2
Ho, S.N.3
Northrop, J.P.4
Crabtree, G.R.5
-
65
-
-
0026643141
-
Identification of Calcineurin as a key signalling enzyme in T-lymphocyte activation
-
Clipstone, N. A. and Crabtree, G. R., Identification of Calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 1992. 357: 695-697.
-
(1992)
Nature
, vol.357
, pp. 695-697
-
-
Clipstone, N.A.1
Crabtree, G.R.2
-
66
-
-
0025893168
-
Calcineurin is a common target of Cyclophilin-Cyclosporin A and FKBP-FK506 complexes
-
Liu, J., Farmer Jr, J. D., Lane, W. S., Friedman, J., Weissman, I. and Schreiber, S. L., Calcineurin is a common target of Cyclophilin-Cyclosporin A and FKBP-FK506 complexes. Cell 1991. 66: 807-815.
-
(1991)
Cell
, vol.66
, pp. 807-815
-
-
Liu, J.1
Farmer Jr., J.D.2
Lane, W.S.3
Friedman, J.4
Weissman, I.5
Schreiber, S.L.6
-
67
-
-
0029163387
-
CD28 costimulation can promote T cell survival by enhancing the expression of Bel-XL
-
Boise, L. H., Minn, A. J., Noel, P. J., June, C. H., Accavitti, M. A., Lindsten, T. and Thompson, C. B., CD28 costimulation can promote T cell survival by enhancing the expression of Bel-XL. Immunity 1995. 3: 87-98.
-
(1995)
Immunity
, vol.3
, pp. 87-98
-
-
Boise, L.H.1
Minn, A.J.2
Noel, P.J.3
June, C.H.4
Accavitti, M.A.5
Lindsten, T.6
Thompson, C.B.7
-
68
-
-
0030588674
-
Protection against Fas/Apo-1- and Tumor Necrosis Factor-mediated cell death by a novel protein, Sentrin
-
Okura, T., Gong, L., Kamitani, T., Wada, T., Okura, I., Wei, C.-F., Chang, H.-M. and Yeh, T. H., Protection against Fas/Apo-1- and Tumor Necrosis Factor-mediated cell death by a novel protein, Sentrin. J. Immunol. 1996. 157: 4277-4281.
-
(1996)
J. Immunol.
, vol.157
, pp. 4277-4281
-
-
Okura, T.1
Gong, L.2
Kamitani, T.3
Wada, T.4
Okura, I.5
Wei, C.-F.6
Chang, H.-M.7
Yeh, T.H.8
-
69
-
-
1842367285
-
Placing death under control
-
Wallach, D., Placing death under control. Nature 1997. 388: 123-126.
-
(1997)
Nature
, vol.388
, pp. 123-126
-
-
Wallach, D.1
-
70
-
-
0030590875
-
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase
-
Alessi, D. R., Caudwell, F. B., Andjelkovic, M., Hemmings, B. A. and Cohen, P., Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett. 1996. 399: 333-338.
-
(1996)
FEBS Lett.
, vol.399
, pp. 333-338
-
-
Alessi, D.R.1
Caudwell, F.B.2
Andjelkovic, M.3
Hemmings, B.A.4
Cohen, P.5
-
71
-
-
0030710188
-
Transformation of hemato-poietic cells by BCR/ABL requires activation of a PI-Sk/ Akt-dependent pathway
-
Skorski, T., Bellacosa, A., Nieborowska-Skorska, M., Majewski, M., Martinez, R., Choi, J. K., Trotta, R., Wlodarski, P., Perrotti, D., Chan, T. O., Wasik, M. A., Tsichlis, P. N. and Calabretta, B., Transformation of hemato-poietic cells by BCR/ABL requires activation of a PI-Sk/ Akt-dependent pathway. EMBO J. 1997. 16: 6151-6161.
-
(1997)
EMBO J.
, vol.16
, pp. 6151-6161
-
-
Skorski, T.1
Bellacosa, A.2
Nieborowska-Skorska, M.3
Majewski, M.4
Martinez, R.5
Choi, J.K.6
Trotta, R.7
Wlodarski, P.8
Perrotti, D.9
Chan, T.O.10
Wasik, M.A.11
Tsichlis, P.N.12
Calabretta, B.13
-
72
-
-
0029086533
-
Regulation of the Fas apoptotic cell death pathway by Abl
-
McGahon, A. J., Nishioka, W. K., Martin, S. J., Mahboubi, A., Cotter, T. G. and Green, D. R., Regulation of the Fas apoptotic cell death pathway by Abl. J. Biol. Chem. 1995. 270: 22625-22631.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22625-22631
-
-
McGahon, A.J.1
Nishioka, W.K.2
Martin, S.J.3
Mahboubi, A.4
Cotter, T.G.5
Green, D.R.6
-
73
-
-
0031034574
-
Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
-
Kulik, G., Klippel, A. and Weber, M. J., Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 1997. 17: 1595-1606.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
74
-
-
0030904561
-
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
-
Kennedy, S. G., Wagner, A. J., Conzen, S. D., Jordan, J., Bellacosa, A., Tsichlis, P. N. and Hay, N., The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 1997. 11: 701-713.
-
(1997)
Genes Dev.
, vol.11
, pp. 701-713
-
-
Kennedy, S.G.1
Wagner, A.J.2
Conzen, S.D.3
Jordan, J.4
Bellacosa, A.5
Tsichlis, P.N.6
Hay, N.7
-
75
-
-
0030913673
-
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
-
Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P. H. and Downward, J., Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 1997. 16: 2783-2793.
-
(1997)
EMBO J.
, vol.16
, pp. 2783-2793
-
-
Khwaja, A.1
Rodriguez-Viciana, P.2
Wennstrom, S.3
Warne, P.H.4
Downward, J.5
-
76
-
-
0026667730
-
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine threonine kinases, is amplified in human ovarian carcinomas
-
Cheng, J. Q., Godwin, A. K., Bellacosa, A., Taguchi, T., Franke, T. F., Hamilton, T. C., Tsichlis, P. N. and Testa, J. R., AKT2, a putative oncogene encoding a member of a subfamily of protein-serine threonine kinases, is amplified in human ovarian carcinomas. Proc. Natl. Acad. Sci. USA 1992. 89: 9267-9271.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 9267-9271
-
-
Cheng, J.Q.1
Godwin, A.K.2
Bellacosa, A.3
Taguchi, T.4
Franke, T.F.5
Hamilton, T.C.6
Tsichlis, P.N.7
Testa, J.R.8
-
77
-
-
0001457668
-
Amplification of AKT2 in human pancreatic-cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
-
Cheng, J. Q., Ruggeri, B., Klein, W. M., Sonoda, G., Altomare, D. A., Watson, D. K. and Testa, J. R., Amplification of AKT2 in human pancreatic-cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc. Natl. Acad. Sci. USA 1996. 93: 3636-3641.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 3636-3641
-
-
Cheng, J.Q.1
Ruggeri, B.2
Klein, W.M.3
Sonoda, G.4
Altomare, D.A.5
Watson, D.K.6
Testa, J.R.7
-
78
-
-
0025726216
-
A rapid and simple method for measuring thymocyte apoptosis by propidium staining and flow cytometry
-
Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. and Riccardi, C., A rapid and simple method for measuring thymocyte apoptosis by propidium staining and flow cytometry. J. Immunol. Methods 1991. 139: 271-279.
-
(1991)
J. Immunol. Methods
, vol.139
, pp. 271-279
-
-
Nicoletti, I.1
Migliorati, G.2
Pagliacci, M.C.3
Grignani, F.4
Riccardi, C.5
-
79
-
-
0028146616
-
Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase
-
Okada, T., Sakuma, L., Fukui, Y., Hazeki, O. and Ui, M., Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase. J. Biol. Chem. 1994. 269: 3653-3667.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 3653-3667
-
-
Okada, T.1
Sakuma, L.2
Fukui, Y.3
Hazeki, O.4
Ui, M.5
-
80
-
-
0025731596
-
Pathway of phosphatidylinositol (3,4,5)-trisphosphate synthesis and activated neutrophils
-
Stephens, L. R., Hughes, K. T. and Irvine, R. F., Pathway of phosphatidylinositol (3,4,5)-trisphosphate synthesis and activated neutrophils. Nature 1991. 351: 33-39.
-
(1991)
Nature
, vol.351
, pp. 33-39
-
-
Stephens, L.R.1
Hughes, K.T.2
Irvine, R.F.3
|