Elongated telomeres in scid mice

Genomics

Volumn 56, Issue 2, 1999, Pages 221-223

  Hande, Prakash ^a   Slijepcevic, Predrag ^b   Silver, Andy ^c   Bouffler, Simon ^b   Van Buul, Paul ^d   Bryant, Peter ^b   Lansdorp, Peter ^a  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF ST ANDREWS   (United Kingdom)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMBINED IMMUNODEFICIENCY; ENZYME SUBUNIT; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TELOMERE;

ATAXIA; ATAXIA TELANGIECTASIA; MAMMALIA; RODENTIA;

EID: 0033104830     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1998.5668     Document Type: Article

References (14)

1. Araki R., Fujimori A., Hamatani K., Mita K., Saito T., Mori M., Fukumura R., Morimyo M., Muto M., Itoh M., Tatsumi K., Abe M. Nonsense mutation at T4r-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Proc. Natl. Acad. Sci. USA. 94:1997;2438-2443.
2. Blunt T., Finnie N. J., Taccioli G. E., Smith G. C. M., Demengeot J., Gottlieb T. M., Mizuta R., Varghese A. J., Alt F. W., Jeggo P. A., Jackson S. P. Cell. 80:1995;813-823.
3. Boulton S. J., Jackson S. P. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17:1998;1819-1828.
4. Boulton S. J., Jackson S. P. Identification of aSaccharomyces cerevisiae. Nucleic Acids Res. 24:1996;4639-4648.
5. Gravel S., Larrivee M., Labrecque P., Wellinger R. J. Yeast Ku is a regulator of chromosomal DNA end-structure. Science. 280:1998;741-744.
6. Greenwell P. W., Kronmal S. L., Porter S. E., Gassenhuber J., Obermaier B., Petes T. D. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell. 82:1995;823-829.
7. Jeggo P. A. DNA-PK: At the crossroads of biochemistry and genetics. Mutat. Res. 384:1997;1-14.
8. Kirchessner C. U., Patil C. K., Evans J. W., Cuomo C. A., Fried L. M., Carter T., Oetlinger M. A., Brown J. M. DNA dependent kinase (p350) as a candidate gene for the murine scid defect. Science. 267:1995;1178-1183.
9. Metcalfe J. A., Parkhill J., Campbell L., Stacey M., Biggs P., Byrd P. J., Taylor A. M. Accelerated telomere shortening in ataxia telangiectasia. Nat. Genet. 13:1996;350-353.
10. Morrow D. M., Tagle D. A., Shiloh Y., Collins F. S., Hieter P. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell. 82:1995;831-840.
11. Nugent C. I., Bosco G., Ross L., Evans S. K., Salinger A. P., Moore J. K., Haber J., Lundblad V. Telomere maintenance is dependent on activities required for end-repair of double strand breaks. Curr. Biol. 8:1998;657-660.
12. Polotnianka R. M., Li J., Lustig A. J. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Curr. Biol. 8:1998;831-834.
13. Slijepcevic P., Hande M. P., Bouffler S. D., Lansdorp P. Telomere length, chromatin structure and chromosome fusigenic potential. Chromosoma. 106:1997;413-421.
14. Zijlmans J. M. J. M., Martens U. M., Poon S. S., Raap A. K., Tanke H. J., Ward R. K., Lansdorp P. M. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc. Natl. Acad. Sci. USA. 94:1997;7423-7428.