-
1
-
-
0029563009
-
Telomeres: Beginning to understand the end
-
Zakian V.A. Telomeres: beginning to understand the end. Science. 270:1995;1601-1607.
-
(1995)
Science
, vol.270
, pp. 1601-1607
-
-
Zakian, V.A.1
-
2
-
-
0032522443
-
The telomerase reverse transcriptase: Components and regulation
-
Nugent C.I., Lundblad V. The telomerase reverse transcriptase: components and regulation. Genes Dev. 12:1998;1073-1085.
-
(1998)
Genes Dev
, vol.12
, pp. 1073-1085
-
-
Nugent, C.I.1
Lundblad, V.2
-
3
-
-
0031027618
-
Control of telomere length by the human telomeric protein TRF1
-
van Steensel B., de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature. 385:1997;740-743.
-
(1997)
Nature
, vol.385
, pp. 740-743
-
-
Van Steensel, B.1
De Lange, T.2
-
4
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
Structures formed by a model telomeric DNA and by purified cellular telomeric DNA were examined by electron microscopy. In vitro, model telomeric DNAs incubated with TRF2 form loops of duplex DNA with TRF2 bound at the tail/loop junction. Analysis of purified, de-proteinized cellular telomeric DNA also revealed large duplex DNA loops as well as a single-stranded displacement loop at the tail/loop junction.
-
Griffith J.D., Comeau L., Rosenfield S., Stansel R.M., Bianchi A., Moss H., de Lange T. Mammalian telomeres end in a large duplex loop. Cell. 97:1999;503-514. Structures formed by a model telomeric DNA and by purified cellular telomeric DNA were examined by electron microscopy. In vitro, model telomeric DNAs incubated with TRF2 form loops of duplex DNA with TRF2 bound at the tail/loop junction. Analysis of purified, de-proteinized cellular telomeric DNA also revealed large duplex DNA loops as well as a single-stranded displacement loop at the tail/loop junction.
-
(1999)
Cell
, vol.97
, pp. 503-514
-
-
Griffith, J.D.1
Comeau, L.2
Rosenfield, S.3
Stansel, R.M.4
Bianchi, A.5
Moss, H.6
De Lange, T.7
-
5
-
-
0033961281
-
Control pf human telomere length by TRF1 and TRF2
-
Smorgorzewska A., van Steensel B., Bianchi A., Oelmann S., Schaefer M.R., Schnapp G., de Lange T. Control pf human telomere length by TRF1 and TRF2. Mol Cell Biol. 20:2000;1659-1668.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1659-1668
-
-
Smorgorzewska, A.1
Van Steensel, B.2
Bianchi, A.3
Oelmann, S.4
Schaefer, M.R.5
Schnapp, G.6
De Lange, T.7
-
6
-
-
0032489012
-
TRF2 protects human telomeres from end-to-end fusions
-
The effects of over-expression of wild-type or truncated TRF2 proteins were examined in cultured cells. Over-expression of TRF2 lacking its basic domain induced senesence. Over-expression of dominant negative TRF2 induced senesence, loss of single-stranded telomeric repeats, and end-to-end chromosome fusions.
-
van Steensel B., Smogorzewska A., de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell. 92:1998;401-413. The effects of over-expression of wild-type or truncated TRF2 proteins were examined in cultured cells. Over-expression of TRF2 lacking its basic domain induced senesence. Over-expression of dominant negative TRF2 induced senesence, loss of single-stranded telomeric repeats, and end-to-end chromosome fusions.
-
(1998)
Cell
, vol.92
, pp. 401-413
-
-
Van Steensel, B.1
Smogorzewska, A.2
De Lange, T.3
-
7
-
-
0033605145
-
P53- And ATM-dependent apoptosis induced by telomeres lacking TRF2
-
The effects of over-expression of wild-type or truncated telomere-binding proteins were examined in cultured cells. Dominant negative TRF2 was shown to induce apoptosis, but only in cells with a functional p53/ATM DNA damage response pathway. Induction of apoptosis did not require TRF2-induced chromosome rearrangements.
-
Karlseder J., Broccoli D., Dai Y., Hardy S., de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science. 283:1999;1321-1325. The effects of over-expression of wild-type or truncated telomere-binding proteins were examined in cultured cells. Dominant negative TRF2 was shown to induce apoptosis, but only in cells with a functional p53/ATM DNA damage response pathway. Induction of apoptosis did not require TRF2-induced chromosome rearrangements.
-
(1999)
Science
, vol.283
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
Dai, Y.3
Hardy, S.4
De Lange, T.5
-
8
-
-
0032553473
-
Tankyrase, a poly(ADP ribose) polymerase at human telomeres
-
Tankyrase was identified by interaction with TRF1 in a yeast two-hybrid assay and shown to localize to human telomeres. Recombinant tankyrase ADP-ribosylates itself and TRF1 in an in vitro assay for ADP ribosylation.
-
Smith S., Giriat I., Schmitt A., de Lange T. Tankyrase, a poly(ADP ribose) polymerase at human telomeres. Science. 282:1998;1484-1487. Tankyrase was identified by interaction with TRF1 in a yeast two-hybrid assay and shown to localize to human telomeres. Recombinant tankyrase ADP-ribosylates itself and TRF1 in an in vitro assay for ADP ribosylation.
-
(1998)
Science
, vol.282
, pp. 1484-1487
-
-
Smith, S.1
Giriat, I.2
Schmitt, A.3
De Lange, T.4
-
9
-
-
0032727616
-
TIN2, a new regulator of telomere length in human cells
-
TIN2 was identified by interaction with TRF1 in a yeast two-hybrid assay and shown to localize to human telomeres. Over-expression of truncated TIN2 resulted in telomere lengthening. Recombinant TIN2 bound to TRF1 in a manner that did not disrupt the interaction of TRF1 with telomeric DNA.
-
Kim S., Kaminker P., Campisi J. TIN2, a new regulator of telomere length in human cells. Nat Genet. 23:1999;405-412. TIN2 was identified by interaction with TRF1 in a yeast two-hybrid assay and shown to localize to human telomeres. Over-expression of truncated TIN2 resulted in telomere lengthening. Recombinant TIN2 bound to TRF1 in a manner that did not disrupt the interaction of TRF1 with telomeric DNA.
-
(1999)
Nat Genet
, vol.23
, pp. 405-412
-
-
Kim, S.1
Kaminker, P.2
Campisi, J.3
-
10
-
-
0033597820
-
Ku binds telomeric DNA in vitro
-
Bianchi A., de Lange T. Ku binds telomeric DNA in vitro. J Biol Chem. 274:1999;21223-21227.
-
(1999)
J Biol Chem
, vol.274
, pp. 21223-21227
-
-
Bianchi, A.1
De Lange, T.2
-
12
-
-
0027263365
-
Nuclear proteins that bind the pre-mRNA 3′ splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n
-
Ishikawa F., Matunis M.J., Dreyfuss G., Cech T.R. Nuclear proteins that bind the pre-mRNA 3′ splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol. 13:1993;4301-4310.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 4301-4310
-
-
Ishikawa, F.1
Matunis, M.J.2
Dreyfuss, G.3
Cech, T.R.4
-
13
-
-
0033134777
-
Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA
-
Ding J., Hayashi M.K., Zhang Y., Manche L., Krainer A.R., Xu R. Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes Dev. 13:1999;1102-1115.
-
(1999)
Genes Dev
, vol.13
, pp. 1102-1115
-
-
Ding, J.1
Hayashi, M.K.2
Zhang, Y.3
Manche, L.4
Krainer, A.R.5
Xu, R.6
-
14
-
-
0029778191
-
Requirement for Ku80 in growth and immunoglobin V(D)J recombination
-
Nussenzweig A., Chen C., Soares CdC., Sanchez M., Sokol K., Nussenzweig M.C., Li G.C. Requirement for Ku80 in growth and immunoglobin V(D)J recombination. Nature. 382:1996;551-555.
-
(1996)
Nature
, vol.382
, pp. 551-555
-
-
Nussenzweig, A.1
Chen, C.2
Soares, Cd.c.3
Sanchez, M.4
Sokol, K.5
Nussenzweig, M.C.6
Li, G.C.7
-
15
-
-
0032827888
-
Deletion of Ku86 causes early onset of senescence in mice
-
Vogel H., Lim D., Karsenty G., Finegold M., Hasty P. Deletion of Ku86 causes early onset of senescence in mice. Proc Natl Acad Sci USA. 96:1999;10770-10775.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 10770-10775
-
-
Vogel, H.1
Lim, D.2
Karsenty, G.3
Finegold, M.4
Hasty, P.5
-
16
-
-
0031800617
-
Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase
-
LaBranche H., Dupuis S., Ben-David Y., Bani M., Wellinger R.J., Chabot B. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nat Genet. 19:1998;199-202.
-
(1998)
Nat Genet
, vol.19
, pp. 199-202
-
-
Labranche, H.1
Dupuis, S.2
Ben-David, Y.3
Bani, M.4
Wellinger, R.J.5
Chabot, B.6
-
17
-
-
0032562649
-
TRF1 promotes parallel pairing of telomeric tracts in vitro
-
Griffith J., Bianchi A., de Lange T. TRF1 promotes parallel pairing of telomeric tracts in vitro. J Mol Biol. 278:1998;79-88.
-
(1998)
J Mol Biol
, vol.278
, pp. 79-88
-
-
Griffith, J.1
Bianchi, A.2
De Lange, T.3
-
18
-
-
0033199695
-
Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body
-
Yeager T.R., Neumann A.A., Englezou A., Huschtscha L.I., Noble J.R., Reddel R.R. Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res. 59:1999;4175-4179.
-
(1999)
Cancer Res
, vol.59
, pp. 4175-4179
-
-
Yeager, T.R.1
Neumann, A.A.2
Englezou, A.3
Huschtscha, L.I.4
Noble, J.R.5
Reddel, R.R.6
-
19
-
-
0033616762
-
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
-
Zhu J., Wang H., Bishop J.M., Blackburn E.H. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci USA. 96:1999;3723-3728.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3723-3728
-
-
Zhu, J.1
Wang, H.2
Bishop, J.M.3
Blackburn, E.H.4
-
20
-
-
0002952287
-
Telomere proteins
-
E.H. Blackburn, & C.W. Greider. Cold Spring Harbor, New York: Cold Spring Harbor Press
-
Fang G., Cech T.R. Telomere proteins. Blackburn E.H., Greider C.W. Telomeres. 1995;69-105 Cold Spring Harbor Press, Cold Spring Harbor, New York.
-
(1995)
Telomeres
, pp. 69-105
-
-
Fang, G.1
Cech, T.R.2
-
21
-
-
0033406877
-
Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops
-
••], but macronuclear chromosome ends did not.
-
••], but macronuclear chromosome ends did not.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14436-14439
-
-
Murti, K.G.1
Prescott, D.M.2
-
22
-
-
0030681073
-
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
-
Kilian A., Bowtell D.D.L., Abud H.E., Hime G.R., Venter D.J., Keese P.K., Duncan E.L., Reddel R.R., Jefferson R.A. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet. 6:1997;2011-2019.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 2011-2019
-
-
Kilian, A.1
Bowtell, D.D.L.2
Abud, H.E.3
Hime, G.R.4
Venter, D.J.5
Keese, P.K.6
Duncan, E.L.7
Reddel, R.R.8
Jefferson, R.A.9
-
23
-
-
0032530136
-
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts
-
Ulaner G.A., Hu J., Vu T.H., Giudice L.C., Hoffman A.R. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res. 58:1998;4168-4172.
-
(1998)
Cancer Res
, vol.58
, pp. 4168-4172
-
-
Ulaner, G.A.1
Hu, J.2
Vu, T.H.3
Giudice, L.C.4
Hoffman, A.R.5
-
24
-
-
0033609046
-
Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes
-
Liu K., Schoonmaker M.M., Levine B.L., June C.H., Hodes R.J., Weng N. Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes. Proc Natl Acad Sci USA. 96:1999;5147-5152.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 5147-5152
-
-
Liu, K.1
Schoonmaker, M.M.2
Levine, B.L.3
June, C.H.4
Hodes, R.J.5
Weng, N.6
-
25
-
-
0032509350
-
Telomerase is controlled by protein kinase Ca in human breast cancer cells
-
Li H., Zhao L., Yang Z., Funder J.W., Liu J. Telomerase is controlled by protein kinase Ca in human breast cancer cells. J Biol Chem. 273:1998;33436-33442.
-
(1998)
J Biol Chem
, vol.273
, pp. 33436-33442
-
-
Li, H.1
Zhao, L.2
Yang, Z.3
Funder, J.W.4
Liu, J.5
-
26
-
-
0033532056
-
Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
-
Kang S.S., Kwon T., Kwon D.Y., Do S.I. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J Biol Chem. 274:1999;13085-13090.
-
(1999)
J Biol Chem
, vol.274
, pp. 13085-13090
-
-
Kang, S.S.1
Kwon, T.2
Kwon, D.Y.3
Do, S.I.4
-
27
-
-
0032961170
-
A box H/ACA small nucleolar RNA like domain at the human telomerase RNA 3′ end
-
The 3′ region of human telomerase RNA was shown to have structural and functional similarities with the H/ACA family of snoRNAs. Conserved H/ACA motif elements were required for telomerase RNA stability and processing, and telomerase-specific features of the H/ACA domain were required for catalytic activity of RNPs assembled in vivo.
-
Mitchell J.R., Cheng J., Collins K. A box H/ACA small nucleolar RNA like domain at the human telomerase RNA 3′ end. Mol Cell Biol. 19:1999;567-576. The 3′ region of human telomerase RNA was shown to have structural and functional similarities with the H/ACA family of snoRNAs. Conserved H/ACA motif elements were required for telomerase RNA stability and processing, and telomerase-specific features of the H/ACA domain were required for catalytic activity of RNPs assembled in vivo.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 567-576
-
-
Mitchell, J.R.1
Cheng, J.2
Collins, K.3
-
28
-
-
0033153297
-
Guided tours: From precursor snoRNA to functional snoRNP
-
Weinstein L.B., Steitz J.A. Guided tours: from precursor snoRNA to functional snoRNP. Curr Opin Cell Biol. 11:1999;378-384.
-
(1999)
Curr Opin Cell Biol
, vol.11
, pp. 378-384
-
-
Weinstein, L.B.1
Steitz, J.A.2
-
29
-
-
0029945504
-
Pseudouridine synthases: Four families of enzymes containing a putative uridine-binding motif also conserved in dUTPases and dCTP deaminases
-
Koonin E.V. Pseudouridine synthases: four families of enzymes containing a putative uridine-binding motif also conserved in dUTPases and dCTP deaminases. Nucleic Acids Res. 24:1996;2411-2415.
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 2411-2415
-
-
Koonin, E.V.1
-
30
-
-
0031799895
-
X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions
-
The gene encoding dyskerin was identified as the basis of X-linked DKC. Several mutant alleles of the dyskerin gene were sequenced.
-
Heiss N.S., Knight S.W., Vulliamy T.J., Klauck S.M., Wiemann S., Mason P.J., Poustka A., Dokal I. X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat Genet. 19:1998;32-38. The gene encoding dyskerin was identified as the basis of X-linked DKC. Several mutant alleles of the dyskerin gene were sequenced.
-
(1998)
Nat Genet
, vol.19
, pp. 32-38
-
-
Heiss, N.S.1
Knight, S.W.2
Vulliamy, T.J.3
Klauck, S.M.4
Wiemann, S.5
Mason, P.J.6
Poustka, A.7
Dokal, I.8
-
31
-
-
0033518188
-
A telomerase component is defective in the human disease dyskeratosis congenital
-
Dyskerin was shown to be a component of conventional H/ACA snoRNPs and the human telomerase RNP. Single amino-acid substitutions in dyskerin that cause the disease dyskeratosis congenita did not affect conventional H/ACA snoRNP function but did reduce the accumulation of telomerase RNP. Cells from patients with the disease had abnormally short telomeres, potentially accounting for the disease phenotypes.
-
Mitchell J.R., Wood E., Collins K. A telomerase component is defective in the human disease dyskeratosis congenital. Nature. 402:1999;551-555. Dyskerin was shown to be a component of conventional H/ACA snoRNPs and the human telomerase RNP. Single amino-acid substitutions in dyskerin that cause the disease dyskeratosis congenita did not affect conventional H/ACA snoRNP function but did reduce the accumulation of telomerase RNP. Cells from patients with the disease had abnormally short telomeres, potentially accounting for the disease phenotypes.
-
(1999)
Nature
, vol.402
, pp. 551-555
-
-
Mitchell, J.R.1
Wood, E.2
Collins, K.3
-
32
-
-
0033118355
-
Functional requirement of p23 and Hsp90 in telomerase complexes
-
Molecular chaperones were shown to interact with recombinant mammalian TERT and to be associated with active telomerase in cell extract. Depletion of molecular chaperones partially inhibited production of recombinant telomerase activity in vitro, and inhibition of molecular chaperones in vivo inhibited telomerase activity.
-
Holt S.E., Aisner D.L., Baur J., Tesmer V.M., Dy M., Ouellette M., Trager J.B., Morin G.B., Toft D.O., Shay J.W.et al. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 13:1999;817-826. Molecular chaperones were shown to interact with recombinant mammalian TERT and to be associated with active telomerase in cell extract. Depletion of molecular chaperones partially inhibited production of recombinant telomerase activity in vitro, and inhibition of molecular chaperones in vivo inhibited telomerase activity.
-
(1999)
Genes Dev
, vol.13
, pp. 817-826
-
-
Holt, S.E.1
Aisner, D.L.2
Baur, J.3
Tesmer, V.M.4
Dy, M.5
Ouellette, M.6
Trager, J.B.7
Morin, G.B.8
Toft, D.O.9
Shay, J.W.10
-
33
-
-
0032536049
-
Telomeres and senescence: Ending the debate
-
de Lange T. Telomeres and senescence: ending the debate. Science. 279:1998;334-335.
-
(1998)
Science
, vol.279
, pp. 334-335
-
-
De Lange, T.1
-
34
-
-
0033118323
-
Telomeres and telomerase: Broad effects on cell growth
-
Price C.M. Telomeres and telomerase: broad effects on cell growth. Curr Opin Gen Dev. 9:1999;218-224.
-
(1999)
Curr Opin Gen Dev
, vol.9
, pp. 218-224
-
-
Price, C.M.1
-
35
-
-
0033568462
-
Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
-
Dominant negative TERT expression in cells inhibited telomerase activity and resulted in telomere shortening. In cells with short telomeres, telomerase inhibition induced cell death by apoptosis.
-
Zhang X., Mar V., Zhou W., Harrington L., Robinson M.O. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. 13:1999;2388-2399. Dominant negative TERT expression in cells inhibited telomerase activity and resulted in telomere shortening. In cells with short telomeres, telomerase inhibition induced cell death by apoptosis.
-
(1999)
Genes Dev
, vol.13
, pp. 2388-2399
-
-
Zhang, X.1
Mar, V.2
Zhou, W.3
Harrington, L.4
Robinson, M.O.5
-
36
-
-
0032828652
-
Inhibition of telomerase limits the growth of human cancer cells
-
Dominant negative TERT expression in cells inhibited telomerase activity and resulted in telomere shortening. Telomere shortening induced in apoptosis in cell culture and reduced the tumorigenicity of cells in the organism.
-
Hahn W.C., Stewart S.A., Brooks M.W., York S.G., Eaton E., Kurachi A., Beijersbergen R.L., Knoll J.H.M., Meyerson M., Weinberg R.A. Inhibition of telomerase limits the growth of human cancer cells. Nat Med. 5:1999;1164-1170. Dominant negative TERT expression in cells inhibited telomerase activity and resulted in telomere shortening. Telomere shortening induced in apoptosis in cell culture and reduced the tumorigenicity of cells in the organism.
-
(1999)
Nat Med
, vol.5
, pp. 1164-1170
-
-
Hahn, W.C.1
Stewart, S.A.2
Brooks, M.W.3
York, S.G.4
Eaton, E.5
Kurachi, A.6
Beijersbergen, R.L.7
Knoll, J.H.M.8
Meyerson, M.9
Weinberg, R.A.10
-
37
-
-
0033455559
-
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
-
Telomerase inhibition in cells by a modified oligonucleotide resulted in telomere shortening and cell death.
-
Herbert B-S., Pitts A.E., Baker S.I., Hamilton S.E., Wright W.E., Shay J.W., Corey D.R. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci USA. 96:1999;14276-14281. Telomerase inhibition in cells by a modified oligonucleotide resulted in telomere shortening and cell death.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14276-14281
-
-
Herbert, B.-S.1
Pitts, A.E.2
Baker, S.I.3
Hamilton, S.E.4
Wright, W.E.5
Shay, J.W.6
Corey, D.R.7
-
38
-
-
0033062578
-
Telomere maintenance mechanisms and cellular immortalization
-
Colgin L.M., Reddel R.R. Telomere maintenance mechanisms and cellular immortalization. Curr Opin Gen Dev. 9:1999;97-103.
-
(1999)
Curr Opin Gen Dev
, vol.9
, pp. 97-103
-
-
Colgin, L.M.1
Reddel, R.R.2
-
39
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Telomerase activation increased the tumorigenicity of human cells expressing two oncogenes, SV-40 large T antigen and H-rasV12.
-
Hahn W.C., Counter C.M., Lundberg A.S., Beijersbergen R.L., Brooks M.W., Weinberg R.A. Creation of human tumour cells with defined genetic elements. Nature. 400:1999;464-468. Telomerase activation increased the tumorigenicity of human cells expressing two oncogenes, SV-40 large T antigen and H-rasV12.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
40
-
-
0033593814
-
Telomere length dynamics and chromosome instability in cells derived from telomerase null mice
-
Individual telomeres were analyzed in fibroblasts from wild-type and telomerase RNA knockout mice as a function of mouse generation and culture passaging. Telomere dynamics and telomere rearrangements were characterized.
-
Hande M.P., Samper E., Lansdorp P., Blasco M.A. Telomere length dynamics and chromosome instability in cells derived from telomerase null mice. J Cell Biol. 144:1999;589-601. Individual telomeres were analyzed in fibroblasts from wild-type and telomerase RNA knockout mice as a function of mouse generation and culture passaging. Telomere dynamics and telomere rearrangements were characterized.
-
(1999)
J Cell Biol
, vol.144
, pp. 589-601
-
-
Hande, M.P.1
Samper, E.2
Lansdorp, P.3
Blasco, M.A.4
-
41
-
-
0033153424
-
Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
-
Phenotypes in telomerase RNA knockout mice were examined. Several deficiencies of proliferative renewal were evident earlier and more strikingly in mice with shorter wild-type telomere length than the genetic background previously analyzed.
-
Herrera E., Samper E., Martín-Caballero J., Flores J.M., Lee H-W., Blasco M.A. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18:1999;2950-2960. Phenotypes in telomerase RNA knockout mice were examined. Several deficiencies of proliferative renewal were evident earlier and more strikingly in mice with shorter wild-type telomere length than the genetic background previously analyzed.
-
(1999)
EMBO J
, vol.18
, pp. 2950-2960
-
-
Herrera, E.1
Samper, E.2
Martín-Caballero, J.3
Flores, J.M.4
Lee, H.-W.5
Blasco, M.A.6
-
42
-
-
0033104511
-
-/- embryos is associated with failure to close the neural tube
-
-/- embryos is associated with failure to close the neural tube. EMBO J. 18:1999;1172-1181.
-
(1999)
EMBO J
, vol.18
, pp. 1172-1181
-
-
Herrera, E.1
Samper, E.2
Blasco, M.A.3
-
43
-
-
0343750697
-
Impaired germinal center reaction in mice with short telomeres
-
in press.
-
Herrera E., Martinez -A.C., Blasco M.A. Impaired germinal center reaction in mice with short telomeres. EMBO J. 2000;. in press.
-
(2000)
EMBO J
-
-
Herrera, E.1
Martinez, -A.C.2
Blasco, M.A.3
-
44
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Phenotypes in aging telomerase RNA knockout mice were examined. Lifespan and stress responses were compromised by loss of telomerase, as was immune system function. The occurrence of some age-related pathologies was enhanced.
-
Rudolph K.L., Chang S., Lee H-W., Blasco M., Gottlieb G.J., Greider C., DePinho R.A. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 96:1999;701-712. Phenotypes in aging telomerase RNA knockout mice were examined. Lifespan and stress responses were compromised by loss of telomerase, as was immune system function. The occurrence of some age-related pathologies was enhanced.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.-W.3
Blasco, M.4
Gottlieb, G.J.5
Greider, C.6
Depinho, R.A.7
-
45
-
-
0033553516
-
P53 deficiency rescues the adverse effects of telomerase loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Telomerase RNA knockout mice were crossed to p53 null mice. Loss of p53 allowed additional cell proliferation in telomerase RNA knockout mice but did not ultimately rescue proliferative deficiencies. Loss of telomerase increased the tumorigenicity of p53 null cells with short telomeres.
-
Chin L., Artandi S.E., Shen Q., Tam A., Lee S-L., Gottlieb G.J., Greider C.W., DePinho R.A. p53 deficiency rescues the adverse effects of telomerase loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 97:1999;527-538. Telomerase RNA knockout mice were crossed to p53 null mice. Loss of p53 allowed additional cell proliferation in telomerase RNA knockout mice but did not ultimately rescue proliferative deficiencies. Loss of telomerase increased the tumorigenicity of p53 null cells with short telomeres.
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
Tam, A.4
Lee, S.-L.5
Gottlieb, G.J.6
Greider, C.W.7
Depinho, R.A.8
-
46
-
-
0000146723
-
Δ2/3 cancer-prone mouse
-
Telomerase RNA knockout mice were crossed with cancer-prone mice harboring a deletion in the INK4a/ARF locus. Loss of telomerase reduced the tumorigenicity of INK4a null cells.
-
Δ2/3 cancer-prone mouse. Cell. 97:1999;515-525. Telomerase RNA knockout mice were crossed with cancer-prone mice harboring a deletion in the INK4a/ARF locus. Loss of telomerase reduced the tumorigenicity of INK4a null cells.
-
(1999)
Cell
, vol.97
, pp. 515-525
-
-
Greenberg, R.A.1
Chin, L.2
Femino, A.3
Lee, K.-H.4
Gottlieb, G.J.5
Singer, R.H.6
Greider, C.W.7
Depinho, R.A.8
-
47
-
-
0030097639
-
Dyskeratosis congenita: An inherited bone marrow failure syndrome
-
Dokal I. Dyskeratosis congenita: an inherited bone marrow failure syndrome. Br J Haematol. 92:1996;775-779.
-
(1996)
Br J Haematol
, vol.92
, pp. 775-779
-
-
Dokal, I.1
|