WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts

Cancer Research

Volumn 60, Issue 9, 2000, Pages 2372-2376

  Hisama, Fuki M ^a,b   Chen, Yao Hui ^a,b   Meyn, M Stephen ^c   Oshima, Junko ^d   Weissman, Sherman M ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; HELICASE; TELOMERASE;

ANIMAL CELL; ARTICLE; CANCER RISK; CELL DIVISION; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE SEQUENCE; MALIGNANT TRANSFORMATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SENESCENCE; WERNER SYNDROME; WESTERN BLOTTING;

4-NITROQUINOLINE-1-OXIDE; ANIMALS; BLOTTING, WESTERN; CELL LINE, TRANSFORMED; COS CELLS; DNA HELICASES; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HELA CELLS; HUMANS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTAGENS; MUTATION; RECQ HELICASES; RNA; SEQUENCE ANALYSIS, DNA; TELOMERASE; TELOMERE; TRANSFECTION; WERNER SYNDROME;

EID: 0034192355     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Epstein, C. J., Martin, G. M., Schultz, A. L., and Motulsky, A. G. Werner's syndrome: a review of its symptomatology, natural history, pathologic features, genetics, and relationship to the natural aging process. Medicine (Baltimore), 45: 177-221, 1966.
2. Goto, M., Miller, R. W., Ishikawa, Y., and Sugano, H. Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiol. Biomark. Prev., 5: 239-246, 1996.
3. Ogburn, C. E., Oshima, J., Poot, M., Chen, R., Hunt, K. E., Gollahon, K. A., Rabinovitch, P. S., and Martin, G. M. An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants. Hum. Genet. 101: 121-125, 1997.
4. Yu, C. E., Oshima, J., Fu, Y. H., Wijsman, E. M., Hisama, F., Alisch, R., Matthews, S., Nakura, J., Miki, T., Ouais, S., Martin, G. M., Mulligan, J., and Schellenberg, G. D. Positional cloning of the Werner's syndrome gene. Science (Washington DC), 272: 258-262, 1996.
5. Kitao, S., Shimamoto, A., Goto, M., Miller, R. W., Smithson, W. A., Lindor, N. M., and Furuichi, Y. Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome. Nat. Genet., 22: 82-84, 1999.
6. Huang, S., Li, B., Gray, M. D., Oshima, J., Mian, S., and Campisi, J. The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease. Nat. Genet., 20: 114-116, 1998.
7. Gray, M. D., Shen, J-C., Kamath-Loeb, A. S., Blank, A., Sopher, B. L., Martin, G. M., Oshima, J., and Loeb, L. A. The Werner syndrome protein is a DNA helicase. Nat. Genet., 17: 100-103, 1997.
8. Matsumoto, T. A., Shimamoto, A., Goto, M., and Furuichi, Y. Impaired nuclear localization of defective DNA helicases in Werner's syndrome. Nat. Genet., 16: 335-336, 1997.
9. Lebel, M., and Leder, P. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc. Natl. Acad. Sci. USA, 95: 13097-13102, 1998.
10. Bryan, T. M., and Cech, T. R. Telomerase and the maintainance of chromosome ends. Curr. Opin. Cell Biol., 11: 318-324, 1999.
11. Harley, C. B., Futcher, A. B., and Greider, C. W. Telomeres shorten during ageing of human fibroblasts. Nature (Lond.), 345: 458-460, 1990.
12. Jiang, X. R., Jimenez, G., Chang, E., Frolkis, M., Kusler, B., Sage, M., Beeche, M., Bodnar, A. G., Wahl, G. M., Tlsty, T. D., and Chiu, C. P. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat. Genet., 21: 111-114, 1999.
13. Morales, C. P., Holt, S. E., Ouellette, M., Kaur, K. J., Yan, Y., Wilson, K. S., White, M. A., Wright, W. E., and Shay, J. W. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat. Genet., 21: 115-118, 1999.
14. Yu. C. E., Oshima, J., Wijsman, E. M., Nakura, J., Miki, T., Piussan, C., Matthews, S., Fu, Y. H., Mulligan, J., Martin, G. M., Schellenberg, G. D., and the Werner's Syndrome Collaborative Group. Mutations in the consensus helicase domains of the Werner syndrome gene. Am. J. Hum. Genet., 60: 330-341, 1997.
15. Prince, P. R., Ogburn, C. E., Moser, M. J., Emond, M. J., Martin, G. M., and Monnat, R. J., Jr. Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines. Hum. Genet., 105: 132-138, 1999.
16. Counter, C. M., Hahn, W. C., Wei, W., Dickinson Caddle, S., Beijersbergen, R. L., Lansdorp, P. M., Sedivy, J. M., and Weinberg, R. A. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc. Natl. Acad. Sci. USA, 95: 14723-14728, 1998.
17. Marciniak, R. A., Lombard, D. B., Johnson, F. B., and Guarente, L. Nucleolar localization of the Werner syndrome protein in human cells. Proc. Natl. Acad. Sci. USA, 95: 6887-6892, 1998.
18. Huschtscha, L. I., Thompson, K. V. A., and Holliday, R. The susceptibility of Werner's syndrome and other human skin fibroblasts to SV40-induced transformation and immortalization. Proc. R. Soc. Lond. Series B Biol. Sci., 229: 1-12, 1986.
19. Kohda, K., Taka, K., Kasai, H., Nishimura, S., and Kawazoe, Y. Formation of 8-hydroxyguanine residues in cellular DNA exposed to the carcinogen 4-nitroquinoline-1-oxide. Biochem. Biophys. Res. Commun., 139: 626-632, 1986.
20. Watt, P. M., Louis, E. J., Borts, R. H., and Hickson, I. D. Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell, 81: 253-260, 1995.
21. Gangloff, S., McDonald, J. P., Bendixen, C., Arthur, L., and Rothstein, R. The yeast type 1 topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol. Cell. Biol., 14: 8391-8398, 1994.
22. Giesler, T., Baker, K., Zhang, B., McDaniel, L. D., and Schultz, R. A. Correction of the Bloom syndrome cellular phenotypes. Somat. Cell Mol. Genet., 23: 303-312, 1997.
23. Burger, A. M., Double, J. A., and Newell, D. R. Inhibition of telomerase activity by cisplatin in human testicular cancer cells. Eur. J. Cancer, 33: 638-644, 1997.
24. Fu, W., Begley, J. G., Killen, M. W., and Mattson, M. P. Anti-apoptotic role of telomerase in pheochromocytoma cells. J. Biol. Chem., 274: 7264-7271, 1999.
25. Zhu, J., Wang, H., Bishop, J. M., and Blackburn, E. H. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA, 96: 3723-3728, 1999.
26. Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., and de Lange, T. Mammalian telomeres end in a large duplex loop. Cell, 97: 503-514, 1999.
27. von Zglinicki, T., Saretzki, G., Docke, W., and Lotze, C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp. Cell Res., 220: 186-193, 1995.
28. 2+-mediated Fenton reactions has possible biological implications. J. Biol. Chem., 274: 962-971, 1999.
29. Wyllie, F. S., Jones, C. J., Skinner, J. W., Haughton, M. F., Wallis, C., Wynford-Thomas, D., Faragher, R. G., and Kipling, G. Telomerase prevents the accelerated ageing of Werner syndrome fibroblasts. Nat. Genet., 24: 16-17, 2000.