-
1
-
-
0030477686
-
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
-
Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D & Barrett JC 1996 Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. PNAS 93 13742-13747.
-
(1996)
PNAS
, vol.93
, pp. 13742-13747
-
-
Alcorta, D.A.1
Xiong, Y.2
Phelps, D.3
Hannon, G.4
Beach, D.5
Barrett, J.C.6
-
2
-
-
0029145379
-
Evidence for a critical telomere length in senescent human fibroblasts
-
Allsopp RC & Harley CB 1995 Evidence for a critical telomere length in senescent human fibroblasts. Experimental Cell Research 219 130-136.
-
(1995)
Experimental Cell Research
, vol.219
, pp. 130-136
-
-
Allsopp, R.C.1
Harley, C.B.2
-
3
-
-
0026460896
-
Telomere length predicts replicative capacity of human fibroblasts
-
Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW & Harley CB 1992 Telomere length predicts replicative capacity of human fibroblasts. Proceedings of the National Academy of Sciences of the USA 89 10114-10118.
-
(1992)
Proceedings of the National Academy of Sciences of the USA
, vol.89
, pp. 10114-10118
-
-
Allsopp, R.C.1
Vaziri, H.2
Patterson, C.3
Goldstein, S.4
Younglai, E.V.5
Futcher, A.B.6
Greider, C.W.7
Harley, C.B.8
-
5
-
-
0028179423
-
Acid beta-galactosidase: A developmentally regulated marker of endocrine cell precursors in the human fetal pancreas
-
Beattie GM, Levine F, Mally MI, Otonkoski T, O'Brien JS, Salomon DR & Hayek A 1994 Acid beta-galactosidase: a developmentally regulated marker of endocrine cell precursors in the human fetal pancreas. Journal of Clinical Endocrinology and Metabolism 78 1232-1240.
-
(1994)
Journal of Clinical Endocrinology and Metabolism
, vol.78
, pp. 1232-1240
-
-
Beattie, G.M.1
Levine, F.2
Mally, M.I.3
Otonkoski, T.4
O'Brien, J.S.5
Salomon, D.R.6
Hayek, A.7
-
6
-
-
0029795884
-
Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact
-
Beattie GM, Rubin JS, Mally MI, Otonkoski T & Hayek A 1996 Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact. Diabetes 45 1223-1228.
-
(1996)
Diabetes
, vol.45
, pp. 1223-1228
-
-
Beattie, G.M.1
Rubin, J.S.2
Mally, M.I.3
Otonkoski, T.4
Hayek, A.5
-
8
-
-
0032932851
-
Sustained proliferation of PDX-1+ cells derived from human islets
-
Beattie GM, Itkin-Ansari P, Cirulli V, Leibowitz G, Lopez AD, Bossie S, Mally MI, Levine F & Hayek A 1999 Sustained proliferation of PDX-1+ cells derived from human islets. Diabetes 48 1013-1019.
-
(1999)
Diabetes
, vol.48
, pp. 1013-1019
-
-
Beattie, G.M.1
Itkin-Ansari, P.2
Cirulli, V.3
Leibowitz, G.4
Lopez, A.D.5
Bossie, S.6
Mally, M.I.7
Levine, F.8
Hayek, A.9
-
9
-
-
0018253053
-
The effect of donor age on the in vitro life span of cultured human arterial smooth-muscle cells
-
Bierman EL 1978 The effect of donor age on the in vitro life span of cultured human arterial smooth-muscle cells. In Vitro 14 951-955.
-
(1978)
In Vitro
, vol.14
, pp. 951-955
-
-
Bierman, E.L.1
-
10
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S & Wright WE 1998 Extension of life-span by introduction of telomerase into normal human cells (see comments). Science 279 349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
Wright, W.E.10
-
11
-
-
0030964277
-
The biology of replicative senescence
-
Campisi J 1997 The biology of replicative senescence. European Journal of Cancer 33 703-709.
-
(1997)
European Journal of Cancer
, vol.33
, pp. 703-709
-
-
Campisi, J.1
-
12
-
-
0032168373
-
Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation
-
Cristofalo VJ, Allen RG, Pignolo RJ, Martin BG & Beck JC 1998 Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. PNAS 95 10614-10619.
-
(1998)
PNAS
, vol.95
, pp. 10614-10619
-
-
Cristofalo, V.J.1
Allen, R.G.2
Pignolo, R.J.3
Martin, B.G.4
Beck, J.C.5
-
13
-
-
0029821899
-
Vulnerability of islets in the immediate post-transplantation period. Dynamic changes in structure and function
-
Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S & Weir GC 1996 Vulnerability of islets in the immediate post-transplantation period. Dynamic changes in structure and function. Diabetes 45 1161-1167.
-
(1996)
Diabetes
, vol.45
, pp. 1161-1167
-
-
Davalli, A.M.1
Scaglia, L.2
Zangen, D.H.3
Hollister, J.4
Bonner-Weir, S.5
Weir, G.C.6
-
14
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M & Campisi J 1995 A biomarker that identifies senescent human cells in culture and in aging skin in vivo. PNAS 92 9363-9367.
-
(1995)
PNAS
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.10
Peacocke, M.11
Campisi, J.12
-
16
-
-
0033019840
-
Telomerase activity is sufficient to allow transformed cells to escape from crisis
-
Halvorsen TL, Leibowitz G & Levine F 1999 Telomerase activity is sufficient to allow transformed cells to escape from crisis. Molecular and Cellular Biology 19 1864-1870.
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 1864-1870
-
-
Halvorsen, T.L.1
Leibowitz, G.2
Levine, F.3
-
17
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Futcher AB & Greider CW 1990 Telomeres shorten during ageing of human fibroblasts. Nature 345 458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
18
-
-
0023197701
-
Loss of expression of a differentiated function gene, steroid 17 alpha-hydroxylase, as adrenocortical cells senescence in culture
-
Hornsby PJ, Hancock JP, Vo TP, Nason LM, Ryan RF & McAllister JM 1987 Loss of expression of a differentiated function gene, steroid 17 alpha-hydroxylase, as adrenocortical cells senescence in culture. PNAS 84 1580-1584.
-
(1987)
PNAS
, vol.84
, pp. 1580-1584
-
-
Hornsby, P.J.1
Hancock, J.P.2
Vo, T.P.3
Nason, L.M.4
Ryan, R.F.5
McAllister, J.M.6
-
19
-
-
0032923742
-
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
-
Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD & Chiu CP 1999 Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nature Genetics 21 111-114.
-
(1999)
Nature Genetics
, vol.21
, pp. 111-114
-
-
Jiang, X.R.1
Jimenez, G.2
Chang, E.3
Frolkis, M.4
Kusler, B.5
Sage, M.6
Beeche, M.7
Bodnar, A.G.8
Wahl, G.M.9
Tlsty, T.D.10
Chiu, C.P.11
-
20
-
-
6844239526
-
Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: Graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft
-
Keymeulen B, Ling Z, Gorus FK, Delvaux G, Bouwens L, Grupping A, Hendrieckx C, Pipeleers-Marichal M, Van Schravendijk C, Salmela K & Pipeleers DG 1998 Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft. Diabetologia 41 452-459.
-
(1998)
Diabetologia
, vol.41
, pp. 452-459
-
-
Keymeulen, B.1
Ling, Z.2
Gorus, F.K.3
Delvaux, G.4
Bouwens, L.5
Grupping, A.6
Hendrieckx, C.7
Pipeleers-Marichal, M.8
Van Schravendijk, C.9
Salmela, K.10
Pipeleers, D.G.11
-
21
-
-
0032487675
-
Both Rb/p16 INK-4a inactivation and telomerase activity are required to immortalize human epithelial cells
-
Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA & Klingelhutz AJ 1998 Both Rb/p16 INK-4a inactivation and telomerase activity are required to immortalize human epithelial cells (see comments). Nature 396 84-88.
-
(1998)
Nature
, vol.396
, pp. 84-88
-
-
Kiyono, T.1
Foster, S.A.2
Koop, J.I.3
McDougall, J.K.4
Galloway, D.A.5
Klingelhutz, A.J.6
-
22
-
-
0023897727
-
A simple method of staining fresh and cultured islets
-
Latif ZA, Noel J & Alejandro R 1988 A simple method of staining fresh and cultured islets. Transplantation 45 827-830.
-
(1988)
Transplantation
, vol.45
, pp. 827-830
-
-
Latif, Z.A.1
Noel, J.2
Alejandro, R.3
-
23
-
-
0015741785
-
Long-term culture of human adult liver cells: Morphological changes related to in vitro senescence and effect of donor's age on growth potential
-
Le Guilly Y, Simon M, Lenoir P & Bourel M 1973 Long-term culture of human adult liver cells: morphological changes related to in vitro senescence and effect of donor's age on growth potential. Gerontologia 19 303-313.
-
(1973)
Gerontologia
, vol.19
, pp. 303-313
-
-
Le Guilly, Y.1
Simon, M.2
Lenoir, P.3
Bourel, M.4
-
24
-
-
0033030446
-
Gene transfer to human pancreatic endocrine cells using viral vectors
-
Leibowitz G, Beattie GM, Kafri T, Cirulli V, Lopez AD, Hayek A & Levine F 1999 Gene transfer to human pancreatic endocrine cells using viral vectors. Diabetes 48 745-753.
-
(1999)
Diabetes
, vol.48
, pp. 745-753
-
-
Leibowitz, G.1
Beattie, G.M.2
Kafri, T.3
Cirulli, V.4
Lopez, A.D.5
Hayek, A.6
Levine, F.7
-
25
-
-
0028034775
-
Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb
-
Li Y, Nichols MA, Shay JW & Xiong Y 1994 Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Research 54 6078-6082.
-
(1994)
Cancer Research
, vol.54
, pp. 6078-6082
-
-
Li, Y.1
Nichols, Ma.2
Shay, J.W.3
Xiong, Y.4
-
26
-
-
0017705087
-
In vitro aging. Cytogenetic comparison of diploid human fibroblast and epithelioid cell lines
-
Miller RC, Nichols WW, Pottash J & Aronson MM 1977 in vitro aging. Cytogenetic comparison of diploid human fibroblast and epithelioid cell lines, Experimental Cell Research 110 63-73.
-
(1977)
Experimental Cell Research
, vol.110
, pp. 63-73
-
-
Miller, R.C.1
Nichols, W.W.2
Pottash, J.3
Aronson, M.M.4
-
27
-
-
17344363008
-
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
-
Nakayama J, Tahara H, Tahara E, Saito M, Ito K, Nakamura H, Nakanishi T, Ide T & Ishikawa F 1998 Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nature Genetics 18 65-68.
-
(1998)
Nature Genetics
, vol.18
, pp. 65-68
-
-
Nakayama, J.1
Tahara, H.2
Tahara, E.3
Saito, M.4
Ito, K.5
Nakamura, H.6
Nakanishi, T.7
Ide, T.8
Ishikawa, F.9
-
28
-
-
0033028606
-
Functional characterization of the MODY1 gene mutations HNF4(R127W), HNF4(V255M), and HNF4(E276Q)
-
Navas MA, Munoz-Elias EJ, Kim J, Shih D & Stoffel M 1999 Functional characterization of the MODY1 gene mutations HNF4(R127W), HNF4(V255M), and HNF4(E276Q). Diabetes 48 1459-1465.
-
(1999)
Diabetes
, vol.48
, pp. 1459-1465
-
-
Navas, Ma.1
Munoz-Elias, E.J.2
Kim, J.3
Shih, D.4
Stoffel, M.5
-
29
-
-
0029662028
-
Transfer of p16 inka/CDKN2 gene in leukaemic cell lines inhibits cell proliferation
-
Quesnel B, Preudhomme C, Lepelley P, Hetum D, Vanrumbeke M, Bauters F, Velu T & Fenaux P 1996 Transfer of p16 inka/CDKN2 gene in leukaemic cell lines inhibits cell proliferation. British Journal of Haematology 95 291-298.
-
(1996)
British Journal of Haematology
, vol.95
, pp. 291-298
-
-
Quesnel, B.1
Preudhomme, C.2
Lepelley, P.3
Hetum, D.4
Vanrumbeke M, B.F.5
Velu, T.6
Fenaux, P.7
-
30
-
-
0023758401
-
Crystallins and their synthesis in human lens epithelial cells in tissue culture
-
Reddy VN, Lin LR, Arita T, Zigler JS Jr & Huang QL 1988 Crystallins and their synthesis in human lens epithelial cells in tissue culture. Experimental Eye Research 47 465-478.
-
(1988)
Experimental Eye Research
, vol.47
, pp. 465-478
-
-
Reddy, V.N.1
Lin, L.R.2
Arita, T.3
Zigler J.S., Jr.4
Huang, Q.L.5
-
31
-
-
0023912253
-
Automated method for isolation of human pancreatic islets
-
Ricordi C, Lacy PE, Finke EH, Olack BJ & Scharp DW 1988 Automated method for isolation of human pancreatic islets. Diabetes 37 413-420.
-
(1988)
Diabetes
, vol.37
, pp. 413-420
-
-
Ricordi, C.1
Lacy, P.E.2
Finke, E.H.3
Olack, B.J.4
Scharp, D.W.5
-
33
-
-
0018595902
-
Human lens cells have an in vitro proliferative capacity inversely proportional to the donor age
-
Tassin J, Malaise E & Courtois Y 1979 Human lens cells have an in vitro proliferative capacity inversely proportional to the donor age. Experimental Cell Research 123 388-392.
-
(1979)
Experimental Cell Research
, vol.123
, pp. 388-392
-
-
Tassin, J.1
Malaise, E.2
Courtois, Y.3
-
35
-
-
0033013985
-
Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts
-
Vaziri H, Squire JA, Pandita TK, Bradley G, Kuba RM, Zhang H, Gulyas S, Hill RP, Nolan GP & Benchimol S 1999 Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts. Molecular and Cellular Biology 19 2373-2379.
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 2373-2379
-
-
Vaziri, H.1
Squire, J.A.2
Pandita, T.K.3
Bradley, G.4
Kuba, R.M.5
Zhang, H.6
Gulyas, S.7
Hill, R.P.8
Nolan, G.P.9
Benchimol, S.10
-
36
-
-
0031029972
-
Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas
-
Wang S, Beattie GM, Mally MI, Cirulli V, Itkin-Ansari P, Lopez AD, Hayek A & Levine F 1997 Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas. Cell Transplantation 6 59-67.
-
(1997)
Cell Transplantation
, vol.6
, pp. 59-67
-
-
Wang, S.1
Beattie, G.M.2
Mally, M.I.3
Cirulli, V.4
Itkin-Ansari, P.5
Lopez, A.D.6
Hayek, A.7
Levine, F.8
-
37
-
-
0030659644
-
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
-
Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB & Morin GB 1997 Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nature Genetics 17 498-502.
-
(1997)
Nature Genetics
, vol.17
, pp. 498-502
-
-
Weinrich, S.L.1
Pruzan, R.2
Ma, L.3
Ouellette, M.4
Tesmer, V.M.5
Holt, S.E.6
Bodnar, A.G.7
Lichtsteiner, S.8
Kim, N.W.9
Trager, J.B.10
Taylor, R.D.11
Carlos, R.12
Andrews, W.H.13
Wright, W.E.14
Shay, J.W.15
Harley, C.B.16
Morin, G.B.17
-
39
-
-
0033543760
-
Human endothelial cell life extension by telomerase expression
-
Yang J, Chang E, Cherry AM, Bangs CD, Oei Y, Bodnar A, Bronstein A, Chiu CP & Herron GS 1999 Human endothelial cell life extension by telomerase expression. Journal of Biological Chemistry 274 26141-26148.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 26141-26148
-
-
Yang, J.1
Chang, E.2
Cherry, A.M.3
Bangs, C.D.4
Oei, Y.5
Bodnar, A.6
Bronstein, A.7
Chiu, C.P.8
Herron, G.S.9
|