Normal telomere lengths in young mothers of children with Down's syndrome

Lancet

Volumn 352, Issue 9132, 1998, Pages 961-962

  Dorland, M ^a   Van Montfrans, J M ^b   Van Kooij, R J ^b   Lambalk, C B ^b   Te Velde, E R ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ARTICLE; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; HUMAN; HUMAN CELL; MATERNAL AGE; NORMAL HUMAN; PRIORITY JOURNAL; TELOMERE;

EID: 0032547565     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)61516-4     Document Type: Article

References (5)

1. 1 Schupf N, Kapell D, Lee J-H, Ottman R, Mayeux R. Increased risk of Alzheimer's disease in mothers of adults with Down's syndrome. Lancet 1994; 344: 353-56.
2. 2 Hassold T, Chiu D. Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy. Hum Genet 1985; 70: 11-17.
3. 3 Vaziri H, Schachter F, Uchida I, et al. Loss of telomeric DNA during ageing of normal and trisomy 21 human lymphocytes. Am J Hum Genet 1993; 52: 661-67.
4. 4 van Steensel B, de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature 1997; 385: 740-43.
5. 5 Li J, Xu M, Zhou H, Ma J, Potter H. Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell 1997; 90: 917-27.