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0032006298
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Establishment of a BMP-4 morphogen gradient by long-range inhibition
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This paper discusses the role long-range diffusion of noggin and chordin plays in establishing a BMP morphogen gradient.
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Jones CM, Smith JC Establishment of a BMP-4 morphogen gradient by long-range inhibition. Dev Biol. 194:1998;12-17. This paper discusses the role long-range diffusion of noggin and chordin plays in establishing a BMP morphogen gradient.
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Jones, C.M.1
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The inductive properties of mesoderm suggest that the neural crest cells are specified by a BMP gradient
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••] challenge the prevailing view that local interactions between epidermis and neural plate are responsible for determination of neural crest fate. They suggest instead that a gradient of BMP activity directly determines neural plate, neural crest and epidermal fate in the ectoderm.
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••] challenge the prevailing view that local interactions between epidermis and neural plate are responsible for determination of neural crest fate. They suggest instead that a gradient of BMP activity directly determines neural plate, neural crest and epidermal fate in the ectoderm.
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Marchant, L.1
Linker, C.2
Ruiz, P.3
Guerrero, N.4
Mayor, R.5
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0030837822
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The role in neural patterning of translation initiation factor eIF4AII; Induction of neural fold genes
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Although not obvious from its title, this paper addresses the role of intermediate levels of BMP activation in determining neural crest fate. It also revisits the potential role of XASH-3 in dividing the neuroectoderm into territories that will have a neural fate versus a neural crest fate.
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Morgan R, Sargent MG The role in neural patterning of translation initiation factor eIF4AII; induction of neural fold genes. Development. 124:1997;2751-2760. Although not obvious from its title, this paper addresses the role of intermediate levels of BMP activation in determining neural crest fate. It also revisits the potential role of XASH-3 in dividing the neuroectoderm into territories that will have a neural fate versus a neural crest fate.
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Morgan, R.1
Sargent, M.G.2
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0030744740
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Mechanisms of dorsal-ventral patterning in noggin-induced neural tissue
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This is one among a number of papers that show noggin has dose-dependent effects. The authors focus on noggin's role in dorsoventral patterning within neural tissue rather than in the ectoderm. This paper is particularly interesting because it points to a role for cell movement in the establishment of clearly defined dorsoventral territories in neural tissue.
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Knecht AK, Harland RM Mechanisms of dorsal-ventral patterning in noggin-induced neural tissue. Development. 124:1997;2477-2488. This is one among a number of papers that show noggin has dose-dependent effects. The authors focus on noggin's role in dorsoventral patterning within neural tissue rather than in the ectoderm. This paper is particularly interesting because it points to a role for cell movement in the establishment of clearly defined dorsoventral territories in neural tissue.
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Knecht, A.K.1
Harland, R.M.2
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0030919925
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A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish
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Ectopic expression of BMP-4 is used to demonstrate that dorsoventral fate in the ectoderm and mesoderm is related directly or indirectly to the level of BMP activity.
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Neave B, Holder N, Patient R A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish. Mech Dev. 62:1997;183-195. Ectopic expression of BMP-4 is used to demonstrate that dorsoventral fate in the ectoderm and mesoderm is related directly or indirectly to the level of BMP activity.
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Neave, B.1
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0030725089
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A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula
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This paper shows that FGF-8 suppresses BMP expression and suggests that its expression in a dorsoventral gradient at the gastrula margin helps establish a complementary gradient of BMP activity. It also explores the effect of FGFs on convergence movement.
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Furthauer M, Thisse C, Thisse B A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula. Development. 124:1997;4253-4264. This paper shows that FGF-8 suppresses BMP expression and suggests that its expression in a dorsoventral gradient at the gastrula margin helps establish a complementary gradient of BMP activity. It also explores the effect of FGFs on convergence movement.
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Furthauer, M.1
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Thisse, B.3
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Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1
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Wilson PA, Lagna G, Suzuki A, Hemmati-Brivanlou A Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development. 124:1997;3177-3184.
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Wilson, P.A.1
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Fisher S, Amacher SL, Halpern ME Loss of cerebrum function ventralizes the zebrafish embryo. Development. 124:1997;1301-1311.
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Fisher, S.1
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Dino and mercedes, two genes regulating dorsal development in the zebrafish embryo
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Genetic analysis of dorsoventral pattern formation in the zebrafish: Requirement of a BMP-like ventralizing activity and its dorsal repressor
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0030708635
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The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning
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Identification of swirl as a BMP2 homologue provides us with a powerful tool for examining the role of the BMP pathway in early patterning events.
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Kishimoto Y, Lee KH, Zon L, Hammerschmidt M, Schulte-Merker S The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Development. 124:1997;4457-4466. Identification of swirl as a BMP2 homologue provides us with a powerful tool for examining the role of the BMP pathway in early patterning events.
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Kishimoto, Y.1
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0032127505
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Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes
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The authors use a range of dorsalized zebrafish mutants to illustrate how a range of BMP activity divides the ectoderm into territories in which cells adopt a epidermal, neural crest or neural fate. Their analysis provides an alternate explanation for why neural crest is normally found at the boundary of the neural plate and epidermis.
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Nguyen VH, Schmid B, Trout J, Connors SA, Ekker M, Mullins MC Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes. Dev Biol. 199:1998;93-110. The authors use a range of dorsalized zebrafish mutants to illustrate how a range of BMP activity divides the ectoderm into territories in which cells adopt a epidermal, neural crest or neural fate. Their analysis provides an alternate explanation for why neural crest is normally found at the boundary of the neural plate and epidermis.
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Identifying the missing links: Genes that connect neural induction and primary neurogenesis in vertebrate embryos
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This is an excellent review that summarizes information about a number of recently identified genes that potentially link neural induction to the generation of early neurons in the Xenopus neural plate.
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Sasai Y Identifying the missing links: genes that connect neural induction and primary neurogenesis in vertebrate embryos. Neuron. 21:1998;455-458. This is an excellent review that summarizes information about a number of recently identified genes that potentially link neural induction to the generation of early neurons in the Xenopus neural plate.
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Sasai, Y.1
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Opl: A zinc finger protein that regulates neural determination and patterning in Xenopus
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Kuo JS, Patel M, Gamse J, Merzdorf C, Liu X, Apekin V, Sive H Opl: a zinc finger protein that regulates neural determination and patterning in Xenopus. Development. 125:1998;2867-2882.
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Sive, H.7
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26
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0031909463
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Xenopus and Zic-related-1 Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction
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This paper reports a successful strategy for identifying genes that link neural induction to generation of early neurons in the Xenopus nervous system.
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Mizuseki K, Kishi M, Matsui M, Nakanishi S, Sasai Y Xenopus and Zic-related-1 Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction. Development. 125:1998;579-587. This paper reports a successful strategy for identifying genes that link neural induction to generation of early neurons in the Xenopus nervous system.
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Mizuseki, K.1
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Xenopus Zic3, a primary regulator both in neural and neural crest development
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Nakata K, Nagai T, Aruga J, Mikoshiba K Xenopus Zic3, a primary regulator both in neural and neural crest development. Proc Natl Acad Sci USA. 94:1997;11980-11985.
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Xenopus Zic family and its role in neural and neural crest development
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Nakata K, Nagai T, Aruga J, Mikoshiba K Xenopus Zic family and its role in neural and neural crest development. Mech Dev. 75:1998;43-51.
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Nakata, K.1
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Gli/Zic factors pattern the neural plate by defining domains of cell differentiation
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The inhibitory influence of Zic2 on neurogenesis provides an important clue about mechanisms that restrict early neurons to three longitudinal domains in the neural plate.
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Brewster R, Lee J, Ruiz i Altaba A Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. Nature. 393:1998;579-583. The inhibitory influence of Zic2 on neurogenesis provides an important clue about mechanisms that restrict early neurons to three longitudinal domains in the neural plate.
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Nature
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Brewster, R.1
Lee, J.2
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Determination of the zebrafish forebrain: Induction and patterning
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Grinblat Y, Gamse J, Patel M, Sive H Determination of the zebrafish forebrain: induction and patterning. Development. 125:1998;4403-4416.
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Grinblat, Y.1
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Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation
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This paper identifies a new gene that plays an important role in the determination of neural and neuronal fate. The discovery of this gene and others illustrates how multiple potentially interacting pathways are involved in determining neural fate in the ectoderm.
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Kroll KL, Salic AN, Evans LM, Kirschne MW Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development. 125:1998;3247-3258. This paper identifies a new gene that plays an important role in the determination of neural and neuronal fate. The discovery of this gene and others illustrates how multiple potentially interacting pathways are involved in determining neural fate in the ectoderm.
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Development
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Kroll, K.L.1
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SoxD: An essential mediator of induction of anterior neural tissues in Xenopus embryos
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The discovery of SoxD, a neuralizing gene, is particularly interesting because its early expression in the blastoderm may help account for the 'default' ability of the ectoderm to adopt a neural fate.
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Mizuseki K, Kishi M, Shiota K, Nakanishi S, Sasai Y SoxD: an essential mediator of induction of anterior neural tissues in Xenopus embryos. Neuron. 21:1998;77-85. The discovery of SoxD, a neuralizing gene, is particularly interesting because its early expression in the blastoderm may help account for the 'default' ability of the ectoderm to adopt a neural fate.
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Mizuseki, K.1
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Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes
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Gomez-Skarmeta JL, del Corral RD, de la Calle-Mustienes EFerre-, Marco D, Modolell J Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes. Cell. 85:1996;95-105.
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Gomez-Skarmeta, J.L.1
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Bosse A, Zulch A, Becker MB, Torres M, Gomez-Skarmeta JL, Modolell J, Gruss P Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 69:1997;169-181.
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Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate
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This paper explores the role of Xiro genes in determining neural fate and in controlling proneural gene expression in vertebrates. It shows that, like in Drosophila, the vertebrate iroquois genes are upregulated by cubitus interuptus.
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Gomez-Skarmeta JL, Glavic A, de la Calle-Mustienes E, Modolell J, Mayor R Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate. EMBO J. 17:1998;181-190. This paper explores the role of Xiro genes in determining neural fate and in controlling proneural gene expression in vertebrates. It shows that, like in Drosophila, the vertebrate iroquois genes are upregulated by cubitus interuptus.
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Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification
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While the role of proneural and neurogenic gene homologues in the determination of neuronal fate has been emphasized, their role in determining neural fate remains poorly understood in vertebrates. Expansion of the neural plate by ectopic Xiro3 and induction of XASH-3 expression raises important questions about the role of these genes in the determination of neural fate.
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Bellefroid EJ, Kobbe A, Gruss P, Pieler T, Gurdon JB, Papalopulu N Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification. EMBO J. 17:1998;191-203. While the role of proneural and neurogenic gene homologues in the determination of neuronal fate has been emphasized, their role in determining neural fate remains poorly understood in vertebrates. Expansion of the neural plate by ectopic Xiro3 and induction of XASH-3 expression raises important questions about the role of these genes in the determination of neural fate.
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Blader P, Fischer N, Gradwohl G, Guillemont F, Strahle U The activity of neurogenin1 is controlled by local cues in the zebrafish embryo. Development. 124:1997;4557-4569.
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Appel B, Eisen JS Regulation of neuronal specification in the zebrafish spinal cord by Delta function. Development. 125:1998;371-380. Identification of Delta homologues in zebrafish provide additional support for the role of these ligands in selecting neuronal fates in the spinal cord.
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