Effect of PS1 deficiency and an APP γ-secretase inhibitor on Notch1 signaling in primary mammalian neurons

Molecular Brain Research

Volumn 87, Issue 2, 2001, Pages 166-174

  Jack, Christine ^a   Berezovska, Oksana ^a   Wolfe, Michael S ^b   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

Author keywords

Secretase; Alzheimer's disease; Amyloid presursor protein; Notch; Presenilin

Indexed keywords

GAMMA SECRETASE; LUCIFERASE; MUTANT PROTEIN; NOTCH RECEPTOR; PRESENILIN 1; PROTEIN PRECURSOR;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITOR INTERACTION; GENETIC TRANSFECTION; MAMMAL; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; REPORTER GENE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL MEMBRANE; CELL NUCLEUS; CELLS, CULTURED; CEREBRAL CORTEX; DNA-BINDING PROTEINS; ENDOPEPTIDASES; ENZYME INHIBITORS; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; LUCIFERASES; MAMMALS; MEMBRANE PROTEINS; MICE; NEURONS; NUCLEAR PROTEINS; PRESENILIN-1; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; TRANSCRIPTION FACTORS; TRANSFECTION;

MAMMALIA;

EID: 0035809789     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00010-9     Document Type: Article

References (33)

1. Notch signaling
2. Oncogenic forms of Notch1 lacking either the primary binding site for RBP-Jk or nuclear localization signal sequences retain the ability to associate with RBP-Jk and activate transcription
3. Aspartate mutations in presenilin and g-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch signaling
4. The Alzheimer-related gene presenilin 1 facilitates Notch1 in primary mammalian neurons
5. Notch1 inhibits neurite outgrowth in postmitotic primary neurons
6. Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease
7. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
8. Calcium phosphate-mediated gene transfer: A highly efficient system for stably transforming cells with plasmid DNA
9. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos
10. Closing in on γ-secretase
11. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
12. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
13. Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells
14. Drosophila presenilin is required for neuronal differentiation and affects Notch subcellular localization and signaling
15. Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
16. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
17. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
18. Photoactivated γ-secretase inhibitors directed to the active site convalently label presenilin1
19. The Notch1 receptor is cleaved constitutively by a furin-like convertase
20. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
21. Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression
22. Calcium depletion dissociates and activates heterodimeric Notch receptors
23. Cell Surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch
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25. In search of γ-secretase: Presenilin at the cutting edge
26. Contact-dependent inhibition of cortical neurite growth mediated by Notch signaling
27. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
28. Presenilin is required for activity and nuclear access of Notch in Drosophila
29. Notch receptor activation inhibits oligodendrocyte differentiation
30. The ins and outs of Notch signaling
31. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
32. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity
33. Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants