Alterations of the double-strand break repair gene MRE11 in cancer

Cancer Research

Volumn 61, Issue 1, 2001, Pages 23-26

  Fukuda, Toshikatu ^a   Sumiyoshi, Tatsuaki ^a   Takahashi, Mamoru ^a   Kataoka, Tsuyoshi ^a   Asahara, Toshimasa ^a   Inui, Hiroki ^b   Watatani, Masahiro ^b   Yasutomi, Masayuki ^b   Kamada, Nanao ^a   Miyagawa, Kiyoshi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; DOUBLE STRANDED DNA; GENE PRODUCT; MRE11 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ATAXIA TELANGIECTASIA; BREAST TUMOR; CANCER; CARCINOGENESIS; CONTROLLED STUDY; DNA REPAIR; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; LYMPHATIC SYSTEM TUMOR; LYMPHOMA; MISSENSE MUTATION; PRIORITY JOURNAL;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BASE SEQUENCE; BREAST NEOPLASMS; DNA DAMAGE; DNA REPAIR; DNA, NEOPLASM; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; FUNGAL PROTEINS; HUMANS; LYMPHOMA; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NEOPLASMS; POLYMERASE CHAIN REACTION; RNA, NEOPLASM; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035131930     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae
2. The 3′ to 5′ exonuclease activity of MRE11 facilitates repair of DNA double-strand breaks
3. MRE11 is essential for the maintenance of chromosomal DNA in vertebrate cells
4. The MRE11 complex and ATM: Collaborating to navigate S phase
5. The hMRE11/hRAD50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
6. Positional cloning of the gene for Ni megen breakage syndrome
7. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
8. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
9. The Nijmegen breakage syndrome protein is essential for MRE11 phosphorylation upon DNA damage
10. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
11. Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia
12. Mantle cell lymphoma is characterized by inactivation of the ATM gene
13. ATM-deficient mice: A paradigm of ataxia telangiectasia
14. AT-tributable risks?
15. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants
16. Distinct roles of two separable in vitro activities of yeast MRE11 in mitotic and meiotic recombination
17. Ku70: A candidate tumor suppressor gene for murine T cell lymphoma
18. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
19. MRE11S: A yeast mutation that blocks double-strand break processing and permits nonhomologous synapsis in meiosis
20. Isolation and characterization of the human MRE11 homo ogue