Control of chromosomal DNA replication in the early Xenopus embryo

EMBO Journal

Volumn 20, Issue 13, 2001, Pages 3293-3297

  Blow, J J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

DNA replication; Licensing; ORC; SPF; Xenopus

Indexed keywords

DNA;

CELL CYCLE S PHASE; CHROMOSOME; DEVELOPMENTAL GENETICS; DNA REPLICATION; EMBRYO; EMBRYO DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; REVIEW; XENOPUS;

ANIMALS; CHROMOSOMES; DNA REPLICATION; EMBRYO, NONMAMMALIAN; FEMALE; MODELS, BIOLOGICAL; OVUM; REPLICATION ORIGIN; XENOPUS LAEVIS;

EID: 0035796407     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.13.3293     Document Type: Review

References (46)

1. Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs
2. A role for the nuclear envelope in controlling DNA replication within the cell cycle
3. Replication origins in Xenopus egg extract are 5-15 kb apart and are activated in clusters that fire at different times
4. The units of DNA replication in Drosophila melanogaster chromosomes
5. Role for a Xenopus Orc2-related protein in controlling DNA replication
6. Purification of an Mcm-containing complex as a component of the DNA replication licensing system
7. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts
8. Replication origins in metazoan chromosomes: Fact or fiction?
9. Once and only once upon a time: Specifying and regulating origins of DNA replication in eukaryotic cells
10. Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast
11. Regulated DNA replication of DNA microinjected into eggs of Xenopus laevis
12. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2
13. A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle
14. Plasmid replication in Xenopus eggs and egg extracts: A 2D gel electrophoretic analysis
15. Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos
16. Transition in specification of embryonic metazoan DNA replication origins
17. Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading
18. First the CDKs, now the DDKs
19. MCM proteins: Evolution, properties and role in DNA replication
20. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor
21. Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs
22. Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?
23. Formation in vitro of sperm pronuclei and mitotic chromosomes induced by amphibian ooplasmic components
24. DNA replication initiates at multiple sites on plasmid DNA in Xenopus egg extracts
25. Cell cycle regulation of the replication licensing system: Involvement of a Cdk-dependent inhibitor
26. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
27. Geminin, an inhibitor of DNA replication, is degraded during mitosis
28. Xenopus Cdc45-dependent loading of DNA polymerase α onto chromatin under the control of S-phase cdk
29. Central role for Cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts
30. Cyclin synthesis drives the early embryonic cell cycle
31. The Cdt1 protein is required to license DNA for replication in fission yeast
32. Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle
33. Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity
34. 1 phase
35. The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin
36. Interaction between the origin recognition complex and the replication licensing system in Xenopus
37. Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins
38. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase
39. Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts
40. The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins
41. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
42. The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides
43. Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts
44. Regulated chromosomal DNA replication in the absence of a nucleus
45. Inhibition of eukaryotic replication by geminin binding to Cdt1
46. Proteolysis and DNA replication: The CDC34 requirement in the Xenopus egg cell cycle