Caffeine inhibits the checkpoint kinase ATM

Current Biology

Volumn 9, Issue 19, 1999, Pages 1135-1138

  Blasina, Alessandra ^a   Price, Brendan D ^b   Turenne, Gaetan A ^b   McGowan, Clare H ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ZEA MAYS;

EID: 0033533725     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80486-2     Document Type: Article

References (23)

1. Lau CC, Pardee AB: Mechanism by which caffeine potentiates lethality of nitrogen mustard. Proc Natl Acad Sci USA 1982, 79:2942-2946.
2. Schlegel R, Pardee AB: Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science 1986, 232:1264-1266.
3. Hartwell LH, Kastan MB: Cell cycle control and cancer. Science 1994, 266:1821-1828.
4. Blasina A, de Weyer IV, Laus MC, Luyten W, Parker AE, McGowan CH: A human homologue of the checkpoint kinase cds1 directly inhibits cdc25 phosphatase. Curr Biol 1999, 9:1-10.
5. Matsuoka S, Huang M, Elledge SJ: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998, 282:1893-1897.
6. Powell SN, Defrank JS, Connell P, Eogan M, Preffer F, Dombkowski D, et al.: Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay. Cancer Res 1995, 55:1643-1648.
7. Russell KJ, Wiens LW, Demers GW, Galloway DA, Plon SE, et al.: Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells. Cancer Res 1995, 55:1639-1642.
8. Yao SL, Akhtar AJ, McKenna KA, Bedi GC, Sidransky D, Mabry M: Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase. Nat Med 1996, 2:1140-1143.
9. Jin P, Gu Y, Morgan DO: Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells. J Cell Biol 1996, 134:963-970.
10. Blasina A, Paegle ES, McGowan CH: The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation induced damage in HeLa cells. Mol Biol Cell 1997, 8:1-11.
11. Rhind N, Russell P: Mitotic DNA damage and replication checkpoints in yeast. Curr Opin Cell Biol 1998, 10:749-758.
12. Peng C-Y, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H: Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 1997, 277:1501-1505.
13. Lopez-Girona A, Furnari B, Mondesert O, Russell P: Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature 1999, 397:172-175.
14. Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, et al: Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to cdk regulation through cdc25. Science 1997, 277:1497-1501.
15. Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT: Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res 1998, 58:4375-4382.
16. Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, et al.: Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998, 281:1674-1677.
17. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al.: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998, 281:1677-1679.
18. Brown AL, Lee CH, Schwarz JK, Mitiku N, Piwnica-Worms H, Chung JH: A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc Natl Acad Sci USA 1999, 96:3745-3750.
19. Poon R, Chau M, Yamashita K, Hunter T: The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells. Cancer Res 1997, 57:5168-5178.
20. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991, 51:6304-6311.
21. Dasso M, Newport JW: Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus. Cell 1990, 61:811-823.
22. Kumagai A, Guo Z, Emami KH, Wang SX, Dunphy WG: The Xenopus chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. J Cell Biol 1998, 142:1559-1569.
23. Lavin MF, Shiloh Y: The genetic defect in ataxia-telangiectasia. Anna Rev Immunol 1997, 15:177-202.