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Volumn 8, Issue 6, 1996, Pages 805-814

The retinoblastoma protein pathway and the restriction point

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; PROTEIN KINASE INHIBITOR; RETINOBLASTOMA PROTEIN; RNA POLYMERASE; TRANSCRIPTION FACTOR E2F;

EID: 0030561571     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(96)80081-0     Document Type: Article
Times cited : (376)

References (71)
  • 1
    • 0024473604 scopus 로고
    • G1 events and regulation of cell proliferation
    • Pardee AB. G1 events and regulation of cell proliferation. Science. 246:1989;603-608.
    • (1989) Science , vol.246 , pp. 603-608
    • Pardee, A.B.1
  • 3
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA. The retinoblastoma protein and cell cycle control. Cell. 81:1995;323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 4
    • 0028886364 scopus 로고
    • Unrestricted cell cycling and cancer
    • Strauss M, Lukas J, Bartek J. Unrestricted cell cycling and cancer. Nat Med. 1:1995;1245-1246.
    • (1995) Nat Med , vol.1 , pp. 1245-1246
    • Strauss, M.1    Lukas, J.2    Bartek, J.3
  • 5
    • 0028911033 scopus 로고
    • Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product
    • of outstanding interest. This study provides the first evidence for the involvement of pRb in regulating the synthesis of ribosomal RNA. The ability of pRb to specifically inhibit the activity of RNA polymerase I is dependent on the pRb pocket domain, and is mediated via direct interaction with the pol I transcription factor UBF (upstream-binding factor).
    • Cavanaugh AH, Hempel WM, Taylor LJ, Rogalsky V, Todorov G, Rothblum LI. Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product. of outstanding interest Nature. 374:1995;177-180 This study provides the first evidence for the involvement of pRb in regulating the synthesis of ribosomal RNA. The ability of pRb to specifically inhibit the activity of RNA polymerase I is dependent on the pRb pocket domain, and is mediated via direct interaction with the pol I transcription factor UBF (upstream-binding factor).
    • (1995) Nature , vol.374 , pp. 177-180
    • Cavanaugh, A.H.1    Hempel, W.M.2    Taylor, L.J.3    Rogalsky, V.4    Todorov, G.5    Rothblum, L.I.6
  • 6
    • 0029901988 scopus 로고    scopus 로고
    • Repression of RNA polymerase III transcription by the retinoblastoma protein
    • of outstanding interest. This report demonstrates the ability of pRb to repress transcription by pol III both in vivo and in vitro. Moreover, the pRb-mediated repression of pol III activity is shown to be alleviated by tumour-associated mutations within the pRb pocket domain, and via transforming oncoproteins that bind and inactivate pRb, implying that the restraint of protein biosynthesis may be important in the prevention of tumorigenesis.
    • White RJ, Trouche D, Martin K, Jackson SP, Kouzarides T. Repression of RNA polymerase III transcription by the retinoblastoma protein. of outstanding interest Nature. 382:1996;88-90 This report demonstrates the ability of pRb to repress transcription by pol III both in vivo and in vitro. Moreover, the pRb-mediated repression of pol III activity is shown to be alleviated by tumour-associated mutations within the pRb pocket domain, and via transforming oncoproteins that bind and inactivate pRb, implying that the restraint of protein biosynthesis may be important in the prevention of tumorigenesis.
    • (1996) Nature , vol.382 , pp. 88-90
    • White, R.J.1    Trouche, D.2    Martin, K.3    Jackson, S.P.4    Kouzarides, T.5
  • 8
    • 0029978325 scopus 로고    scopus 로고
    • E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
    • of special interest. See annotation [7].
    • Moberg K, Starz MA, Lees JA. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. of special interest Mol Cell Biol. 16:1996;1436-1449 See annotation [7].
    • (1996) Mol Cell Biol , vol.16 , pp. 1436-1449
    • Moberg, K.1    Starz, M.A.2    Lees, J.A.3
  • 9
    • 9444242683 scopus 로고    scopus 로고
    • Shared role of the pRB-related p130 and p107 proteins in limb development
    • of outstanding interest. This study provides in vivo evidence that two pRb-related pocket proteins, p130 and p107, share limited, tissue-restricted biological functions that could not be fully compensated for by pRb. Mice carrying homozygous mutations of either p107 or p130 developed normally, whereas animals concurrently nullizygous for both p130 and p107 exhibited impaired chondrocyte proliferation, resulting in defective bone development and neonatal lethality.
    • Cobrinik D, Lee M-H, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T. Shared role of the pRB-related p130 and p107 proteins in limb development. of outstanding interest Genes Dev. 10:1996;1633-1644 This study provides in vivo evidence that two pRb-related pocket proteins, p130 and p107, share limited, tissue-restricted biological functions that could not be fully compensated for by pRb. Mice carrying homozygous mutations of either p107 or p130 developed normally, whereas animals concurrently nullizygous for both p130 and p107 exhibited impaired chondrocyte proliferation, resulting in defective bone development and neonatal lethality.
    • (1996) Genes Dev , vol.10 , pp. 1633-1644
    • Cobrinik, D.1    Lee, M.-H.2    Hannon, G.3    Mulligan, G.4    Bronson, R.T.5    Dyson, N.6    Harlow, E.7    Beach, D.8    Weinberg, R.A.9    Jacks, T.10
  • 10
    • 0029736909 scopus 로고    scopus 로고
    • Targeted disruption of p107: Functional overlap between p107 and Rb
    • -/- animals, the authors of this study provide the first in vivo evidence that p107 and pRb have partially overlaping functions in some tissues of the developing and adult mouse.
    • -/- animals, the authors of this study provide the first in vivo evidence that p107 and pRb have partially overlaping functions in some tissues of the developing and adult mouse.
    • (1996) Genes Dev , vol.10 , pp. 1621-1632
    • Lee, M.-H.1    Williams, B.O.2    Mulligan, G.3    Mukai, S.4    Bronson, R.T.5    Dyson, N.6    Harlow, E.7    Jacks, T.8
  • 11
    • 0029863840 scopus 로고    scopus 로고
    • Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts
    • 1 phase, and are more resistant to cycloheximide-mediated inhibition of proteosynthesis as compared with their wild-type littermates.
    • 1 phase, and are more resistant to cycloheximide-mediated inhibition of proteosynthesis as compared with their wild-type littermates.
    • (1996) Mol Cell Biol , vol.16 , pp. 2402-2407
    • Herrera, R.E.1    Sah, V.P.2    Williams, B.O.3    Mäkelä, T.P.4    Weinberg, R.A.5    Jacks, T.6
  • 12
    • 0028925360 scopus 로고
    • Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells, independently of cdk4 activity
    • of outstanding interest. See annotation [11]. This study also shows that cyclin D - Cdk4 operates upstream of pRb.
    • Lukas J, Bartkova J, Rohde M, Strauss M, Bartek J. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells, independently of cdk4 activity. of outstanding interest Mol Cel Biol. 15:1995;2600-2611 See annotation [11]. This study also shows that cyclin D - Cdk4 operates upstream of pRb.
    • (1995) Mol Cel Biol , vol.15 , pp. 2600-2611
    • Lukas, J.1    Bartkova, J.2    Rohde, M.3    Strauss, M.4    Bartek, J.5
  • 13
    • 0029924241 scopus 로고    scopus 로고
    • Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites
    • of special interest. Properties of pRb mutants lacking specific phosphorylation sites on pRb demonstrate that phosphorylation of Thr821/Thr826 regulates the association of human pRb with LXCXE (single-letter code for amino acids)-motif-containing proteins, whereas phosphorylation of Ser807/Ser811 of pRb is required to disrupt c-Abl binding.
    • Knudsen ES, Wang JYJ. Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. of special interest J Biol Chem. 271:1996;8313-8320 Properties of pRb mutants lacking specific phosphorylation sites on pRb demonstrate that phosphorylation of Thr821/Thr826 regulates the association of human pRb with LXCXE (single-letter code for amino acids)-motif-containing proteins, whereas phosphorylation of Ser807/Ser811 of pRb is required to disrupt c-Abl binding.
    • (1996) J Biol Chem , vol.271 , pp. 8313-8320
    • Knudsen, E.S.1    Wang, J.Y.J.2
  • 14
    • 0028948160 scopus 로고
    • Detection of a novel cell cycle-regulated kinase activity that associates with the amino terminus of the retinoblastoma protein in G2/M phases
    • Sterner JM, Yosihiko M, Goo Kim H, Kennett SB, Templeton DJ, Horowitz JM. Detection of a novel cell cycle-regulated kinase activity that associates with the amino terminus of the retinoblastoma protein in G2/M phases. J Biol Chem. 270:1995;9281-9288.
    • (1995) J Biol Chem , vol.270 , pp. 9281-9288
    • Sterner, J.M.1    Yosihiko, M.2    Goo Kim, H.3    Kennett, S.B.4    Templeton, D.J.5    Horowitz, J.M.6
  • 16
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1995;1149-1163.
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 17
    • 0029009876 scopus 로고
    • Different roles for cyclins D1 and E in regulation of the G1-to-S transition
    • 1→S-phase transition by modulating a different, unknown substrate.
    • 1→S-phase transition by modulating a different, unknown substrate.
    • (1995) Mol Cell Biol , vol.15 , pp. 3463-3469
    • Resnitzky, D.1    Reed, S.I.2
  • 18
    • 0029054399 scopus 로고
    • REtinoblastoma-protein-dependent cell-cycle inhibition by the tumour supressor p16
    • of outstanding interest. This study, together with [19,20], showed that the growth-restraining potential of p16 requires the presence of functional pRb. It was also demonstrated that melanoma-associated point mutations in p16 represent true loss-of-function alleles, supporting the notion of p16 as a bona fide tumour suppressor.
    • Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J. REtinoblastoma-protein-dependent cell-cycle inhibition by the tumour supressor p16. of outstanding interest Nature. 375:1995;503-506 This study, together with [19,20], showed that the growth-restraining potential of p16 requires the presence of functional pRb. It was also demonstrated that melanoma-associated point mutations in p16 represent true loss-of-function alleles, supporting the notion of p16 as a bona fide tumour suppressor.
    • (1995) Nature , vol.375 , pp. 503-506
    • Lukas, J.1    Parry, D.2    Aagaard, L.3    Mann, D.J.4    Bartkova, J.5    Strauss, M.6    Peters, G.7    Bartek, J.8
  • 19
    • 0029052951 scopus 로고
    • Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
    • of outstanding interest. See annotation [18].
    • Koh J, Enders GH, Dynlacht BD, Harlow E. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. of outstanding interest Nature. 375:1995;506-510 See annotation [18].
    • (1995) Nature , vol.375 , pp. 506-510
    • Koh, J.1    Enders, G.H.2    Dynlacht, B.D.3    Harlow, E.4
  • 20
    • 0028983491 scopus 로고
    • ink4 requires functional retinoblastoma protein
    • of outstanding interest. See annotation [18].
    • ink4 requires functional retinoblastoma protein. of outstanding interest Proc Natl Acad Sci USA. 92:1995;6289-6293 See annotation [18].
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6289-6293
    • Medema, R.H.1    Herrera, R.E.2    Lam, F.3    Weinberg, R.A.4
  • 24
    • 0029038504 scopus 로고
    • Cyclin-dependent kinases and pRb: Regulators of the proliferation-differentiation switch
    • Kranenburg O, Van der Eb AJ, Zantema A. Cyclin-dependent kinases and pRb: regulators of the proliferation-differentiation switch. FEBS Letts. 367:1995;103-106.
    • (1995) FEBS Letts , vol.367 , pp. 103-106
    • Kranenburg, O.1    Van Der Eb, A.J.2    Zantema, A.3
  • 25
    • 0030008768 scopus 로고    scopus 로고
    • Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1
    • of special interest. Describes the most direct demonstration so far of a requirement for active E2F complexes in mammalian cell progression.
    • Wu C-L, Classon M, Dyson N, Harlow E. Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. of special interest Mol Cell Biol. 16:1996;3698-3706 Describes the most direct demonstration so far of a requirement for active E2F complexes in mammalian cell progression.
    • (1996) Mol Cell Biol , vol.16 , pp. 3698-3706
    • Wu, C.-L.1    Classon, M.2    Dyson, N.3    Harlow, E.4
  • 27
    • 0029888359 scopus 로고    scopus 로고
    • Tumor induction and tissue atrophy in mice lacking E2F-1
    • of outstanding interest. This study and [28] address the function of E2F1 and pRb - E2F1 complexes in vivo by generating mice that are homozygous for a nonfunctional E2F1 allele. Surprisingly, E2F1-deficient animals are viable and fertile but develop a broad spectrum of tumors. Therefore, E2F1 may serve as either a proto-oncoprotein or as a tumour suppressor, depending on cellular context.
    • Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson NJ. Tumor induction and tissue atrophy in mice lacking E2F-1. of outstanding interest Cell. 85:1996;537-548 This study and [28] address the function of E2F1 and pRb - E2F1 complexes in vivo by generating mice that are homozygous for a nonfunctional E2F1 allele. Surprisingly, E2F1-deficient animals are viable and fertile but develop a broad spectrum of tumors. Therefore, E2F1 may serve as either a proto-oncoprotein or as a tumour suppressor, depending on cellular context.
    • (1996) Cell , vol.85 , pp. 537-548
    • Yamasaki, L.1    Jacks, T.2    Bronson, R.3    Goillot, E.4    Harlow, E.5    Dyson, N.J.6
  • 28
  • 29
    • 0028826881 scopus 로고
    • E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity
    • DeGregori J, Leone G, Ohtani K, Miron A, Nevins JR. E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev. 9:1995;2873-2887.
    • (1995) Genes Dev , vol.9 , pp. 2873-2887
    • DeGregori, J.1    Leone, G.2    Ohtani, K.3    Miron, A.4    Nevins, J.R.5
  • 31
    • 0029926060 scopus 로고    scopus 로고
    • Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit
    • of outstanding interest. Active E2F, released from pRb or the related pocket proteins, failed to induce S phase in the presence of dominant-negative mutants of Cdk2 and Cdk3. Additional data support a pRb-independent contribution of Cdk3 to activation of E2F.
    • Hofmann F, Livingston DM. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. of outstanding interest Genes Dev. 10:1996;851-861 Active E2F, released from pRb or the related pocket proteins, failed to induce S phase in the presence of dominant-negative mutants of Cdk2 and Cdk3. Additional data support a pRb-independent contribution of Cdk3 to activation of E2F.
    • (1996) Genes Dev , vol.10 , pp. 851-861
    • Hofmann, F.1    Livingston, D.M.2
  • 34
    • 0029583648 scopus 로고
    • Regulation of the cyclin E gene by transcription factor E2F1
    • Ohtani K, DeGregori J, Nevins JR. Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci USA. 92:1995;12146-12150.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12146-12150
    • Ohtani, K.1    DeGregori, J.2    Nevins, J.R.3
  • 36
    • 0028980858 scopus 로고
    • Developmental control of the G1 to S transition in Drosophila: Cyclin E is a limiting downstream target of E2F
    • 1 phase can bypass E2F and induce DNA replication.
    • 1 phase can bypass E2F and induce DNA replication.
    • (1995) Genes Dev , vol.9 , pp. 1456-1468
    • Duronio, R.J.1    O'Farrell, P.H.2
  • 37
    • 0030044817 scopus 로고    scopus 로고
    • Cdk inhibitors in development and cancer
    • Harper JW, Elledge SJ. Cdk inhibitors in development and cancer. Curr Opin Genet Dev. 6:1996;56-64.
    • (1996) Curr Opin Genet Dev , vol.6 , pp. 56-64
    • Harper, J.W.1    Elledge, S.J.2
  • 38
    • 0029670840 scopus 로고    scopus 로고
    • CDKN2 expression and its implications for cell immortalization and senescence
    • of special interest. Overexpression of p16 in pRb-negative cells is caused by at least two factors: a loss of repression by pRb, and a gradual accumulation of p16 as the population doubles repeatedly.
    • CDKN2 expression and its implications for cell immortalization and senescence. of special interest Mol Cell Biol. 16:1996;859-867 Overexpression of p16 in pRb-negative cells is caused by at least two factors: a loss of repression by pRb, and a gradual accumulation of p16 as the population doubles repeatedly.
    • (1996) Mol Cell Biol , vol.16 , pp. 859-867
    • Hara, E.1    Smith, R.2    Parry, D.3    Tahara, H.4    Stone, S.5    Peters, G.6
  • 40
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • 1 phase in response to DNA damage, and grew to aberrantly higher saturation densities.
    • 1 phase in response to DNA damage, and grew to aberrantly higher saturation densities.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 42
    • 0029664461 scopus 로고    scopus 로고
    • Kip1 for restriction point control of the fibroblast cell cycle
    • Kip1 by antisense DNA prevents cell cycle arrest in response to mitogen depletion. Both studies suggest p27 as an essential molecular component linking mitogenic signalling to R.
    • Kip1 by antisense DNA prevents cell cycle arrest in response to mitogen depletion. Both studies suggest p27 as an essential molecular component linking mitogenic signalling to R.
    • (1996) Science , vol.272 , pp. 877-880
    • Coats, S.1    Flanagan, W.M.2    Nourse, J.3    Roberts, J.M.4
  • 43
    • 0029666482 scopus 로고    scopus 로고
    • Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (GO state) in fibroblasts
    • of outstanding interest. See annotation [42].
    • Rivard N, L'Allemain G, Bartek J, Pouysségur J. Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (GO state) in fibroblasts. of outstanding interest J Biol Chem. 271:1996;18337-18341 See annotation [42].
    • (1996) J Biol Chem , vol.271 , pp. 18337-18341
    • Rivard, N.1    L'Allemain, G.2    Bartek, J.3    Pouysségur, J.4
  • 44
    • 15844384256 scopus 로고    scopus 로고
    • A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27Kip1-deficient mice
    • -/- animals were enlarged and contained more and smaller cells compared with normal littermates. Moreover, T cells lacking p27 showed enhanced IL-2 responsiveness. The authors concluded that p27 deficiency may cause a cell-autonomous defect, resulting in enhanced proliferation in response to mitogens. See also [45,46].
    • -/- animals were enlarged and contained more and smaller cells compared with normal littermates. Moreover, T cells lacking p27 showed enhanced IL-2 responsiveness. The authors concluded that p27 deficiency may cause a cell-autonomous defect, resulting in enhanced proliferation in response to mitogens. See also [45,46].
    • (1996) Cell , vol.85 , pp. 733-744
    • Fero, M.L.1    Rivkin, M.2    Tasch, M.3    Porter, P.4    Carow, C.E.5    Firpo, E.6    Polyak, K.7    Tsai, L.-H.8    Broudy, V.9    Perlmutter, R.M.10
  • 47
    • 0029024015 scopus 로고
    • Role of the ubiquitin - Proteasome pathway in regulating amounts of the cyclin-dependent kinase inhibitor p27
    • of outstanding interest. This paper provides the first evidence that p27 levels in mammalian cells are regulated by the ubiquitin - proteasome pathway.
    • Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M. Role of the ubiquitin - proteasome pathway in regulating amounts of the cyclin-dependent kinase inhibitor p27. of outstanding interest Science. 269:1995;682-685 This paper provides the first evidence that p27 levels in mammalian cells are regulated by the ubiquitin - proteasome pathway.
    • (1995) Science , vol.269 , pp. 682-685
    • Pagano, M.1    Tam, S.W.2    Theodoras, A.M.3    Beer-Romero, P.4    Del Sal, G.5    Chau, V.6    Yew, P.R.7    Draetta, G.F.8    Rolfe, M.9
  • 48
    • 0029670477 scopus 로고    scopus 로고
    • Translational control of p27Kip1 accumulation during the cell cycle
    • of special interest. This study revealed an additional mechanism of control of p27 protein levels, namely regulation of translation.
    • Hengst L, Reed SI. Translational control of p27Kip1 accumulation during the cell cycle. of special interest Science. 271:1996;1861-1864 This study revealed an additional mechanism of control of p27 protein levels, namely regulation of translation.
    • (1996) Science , vol.271 , pp. 1861-1864
    • Hengst, L.1    Reed, S.I.2
  • 49
    • 0029153609 scopus 로고
    • Kip/cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β
    • INK4B, liberates the p27 CKI from Cdk4/6, and results in redistribution of p72 to Cdk2.
    • INK4B, liberates the p27 CKI from Cdk4/6, and results in redistribution of p72 to Cdk2.
    • (1995) Genes Dev , vol.9 , pp. 1831-1845
    • Reynisdottir, I.1    Polyak, K.2    Iavarone, A.3    Massague, J.4
  • 50
    • 0029050533 scopus 로고
    • Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis
    • of special interest. The authors demonstrate that mouse embryonic fibroblasts lacking both Rb alleles could enter S phase in the presence of the dihydrofolate reductase inhibitor methotrexate.
    • Almasan A, Yin Y, Kelly RE, Lee EY-HP, Bradley A, Li W, Bertino JR, Wahl GM. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. of special interest Proc Natl Acad Sci USA. 92:1995;5436-5440 The authors demonstrate that mouse embryonic fibroblasts lacking both Rb alleles could enter S phase in the presence of the dihydrofolate reductase inhibitor methotrexate.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5436-5440
    • Almasan, A.1    Yin, Y.2    Kelly, R.E.3    Lee, E.Y.-H.P.4    Bradley, A.5    Li, W.6    Bertino, J.R.7    Wahl, G.M.8
  • 53
    • 0028889751 scopus 로고
    • Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
    • of outstanding interest. This paper and [52] report the phenotypic changes in transgenic mice lacking cyclin D1. Cyclin D1 deficient animals showed reduced body size and hypoproliferative symptoms such as retinal dysplasia, failure of the breast epithelium to undergo proliferative changes associated with pregnancy, and defects in jaw development.
    • Fantl V, Stamp G, Andrews A, Rosewell I, Dickson C. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. of outstanding interest Genes Dev. 9:1995;2364-2372 This paper and [52] report the phenotypic changes in transgenic mice lacking cyclin D1. Cyclin D1 deficient animals showed reduced body size and hypoproliferative symptoms such as retinal dysplasia, failure of the breast epithelium to undergo proliferative changes associated with pregnancy, and defects in jaw development.
    • (1995) Genes Dev , vol.9 , pp. 2364-2372
    • Fantl, V.1    Stamp, G.2    Andrews, A.3    Rosewell, I.4    Dickson, C.5
  • 56
    • 0029017456 scopus 로고
    • Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells
    • Liu J-J, Chao J-R, Jiang M-C, Ng S-Y, Jong-Young Yen J, Yang-Yen H-F. Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells. Mol Cell Biol. 15:1995;3654-3663.
    • (1995) Mol Cell Biol , vol.15 , pp. 3654-3663
    • Liu, J.-J.1    Chao, J.-R.2    Jiang, M.-C.3    Ng, S.-Y.4    Jong-Young Yen, J.5    Yang-Yen, H.-F.6
  • 57
    • 0030042598 scopus 로고    scopus 로고
    • Regulation of the cell cycle machinery by oncogenic ras
    • Winston JT, Coats SR, Wang Y-Z, Pledger WJ. Regulation of the cell cycle machinery by oncogenic ras. Oncogene. 12:1996;127-134.
    • (1996) Oncogene , vol.12 , pp. 127-134
    • Winston, J.T.1    Coats, S.R.2    Wang, Y.-Z.3    Pledger, W.J.4
  • 58
    • 85047678184 scopus 로고    scopus 로고
    • Thyrotropin induces G1 cyclin expression and accelerates G1 phase after insulin-like growth factor I stimulation in FRTL-5 cells
    • Yamamoto K, Hirai A, Ban T, Saito J, Tahara K, Terano T, Tamura Y, Saito Y, Kitagawa M. Thyrotropin induces G1 cyclin expression and accelerates G1 phase after insulin-like growth factor I stimulation in FRTL-5 cells. Endocrinology. 137:1996;2036-2042.
    • (1996) Endocrinology , vol.137 , pp. 2036-2042
    • Yamamoto, K.1    Hirai, A.2    Ban, T.3    Saito, J.4    Tahara, K.5    Terano, T.6    Tamura, Y.7    Saito, Y.8    Kitagawa, M.9
  • 59
    • 0029910364 scopus 로고    scopus 로고
    • Convergence of mitogenic signalling cascades from diverse classes of receptors on the cyclin D/cdk-pRb-controlled G1 checkpoint
    • This study provides direct evidence that mitogenic stimuli from distinct signalling cascades (i.e. those activated by growth factors via tyrosine kinase receptors, by estradiol via estrogen receptors, and by cAMP-elevating agents via G protein coupled thyrotropin receptors) all converge and strictly require cyclin D - Cdk activity to promote S-phase onset. of special interest
    • Lukas J, Bartkova J, Bartek J. Convergence of mitogenic signalling cascades from diverse classes of receptors on the cyclin D/cdk-pRb-controlled G1 checkpoint. of special interest Mol Cell Biol. 1996; This study provides direct evidence that mitogenic stimuli from distinct signalling cascades (i.e. those activated by growth factors via tyrosine kinase receptors, by estradiol via estrogen receptors, and by cAMP-elevating agents via G protein coupled thyrotropin receptors) all converge and strictly require cyclin D - Cdk activity to promote S-phase onset.
    • (1996) Mol Cell Biol
    • Lukas, J.1    Bartkova, J.2    Bartek, J.3
  • 60
    • 0029876639 scopus 로고    scopus 로고
    • Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E - Cdk2, and phosphorylation of the retinoblastoma protein
    • Zhu X, Ohtsubo M, Böhmer RM, Roberts JM, Assoian RK. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E - cdk2, and phosphorylation of the retinoblastoma protein. J Cell Biol. 133:1996;391-403.
    • (1996) J Cell Biol , vol.133 , pp. 391-403
    • Zhu, X.1    Ohtsubo, M.2    Böhmer, R.M.3    Roberts, J.M.4    Assoian, R.K.5
  • 61
    • 0030028947 scopus 로고    scopus 로고
    • Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1
    • Böhmer RM, Scharf E, Assoian RK. Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1. Mol Biol Cell. 7:1996;101-111.
    • (1996) Mol Biol Cell , vol.7 , pp. 101-111
    • Böhmer, R.M.1    Scharf, E.2    Assoian, R.K.3
  • 62
    • 0029145975 scopus 로고
    • Redistribution of the CDK inhibitor p27 between different cyclin CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation
    • Poon RYC, Toyoshima H, Hunter T. Redistribution of the CDK inhibitor p27 between different cyclin CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol Biol Cell. 6:1995;1197-1213.
    • (1995) Mol Biol Cell , vol.6 , pp. 1197-1213
    • Poon, R.Y.C.1    Toyoshima, H.2    Hunter, T.3
  • 64
    • 0029941446 scopus 로고    scopus 로고
    • Inhibition of p53-mediated growth arrest by overexpression of cyclin-dependent kinases
    • Latham KM, Eastman SW, Wong A, Hinds PW. Inhibition of p53-mediated growth arrest by overexpression of cyclin-dependent kinases. Mol Cell Biol. 16:1996;4445-4455.
    • (1996) Mol Cell Biol , vol.16 , pp. 4445-4455
    • Latham, K.M.1    Eastman, S.W.2    Wong, A.3    Hinds, P.W.4
  • 65
    • 0029921317 scopus 로고    scopus 로고
    • Genetic alterations of cyclins, cyclin-dependent kinases, and cdk inhibitors in human cancer
    • Hall M, Peters G. Genetic alterations of cyclins, cyclin-dependent kinases, and cdk inhibitors in human cancer. Adv Cancer Res. 68:1996;67-108.
    • (1996) Adv Cancer Res , vol.68 , pp. 67-108
    • Hall, M.1    Peters, G.2
  • 66
    • 0028978274 scopus 로고
    • INK4a-insensitive cdk4 mutant targeted by cytolytic T lymphocytes in a human melanoma
    • of special interest. A point missense mutant Cdk4 found in human melanomas is deficient in its ability to associate with p16, indicating a novel mechanism used by tumour cells to escape from growth-restraining regulation by p16. The results also implicate mutant Cdk4 as a tumour-specific T-cell antigen.
    • INK4a-insensitive cdk4 mutant targeted by cytolytic T lymphocytes in a human melanoma. of special interest Science. 269:1995;1281-1284 A point missense mutant Cdk4 found in human melanomas is deficient in its ability to associate with p16, indicating a novel mechanism used by tumour cells to escape from growth-restraining regulation by p16. The results also implicate mutant Cdk4 as a tumour-specific T-cell antigen.
    • (1995) Science , vol.269 , pp. 1281-1284
    • Wölfel, T.1    Hauer, M.2    Schneider, J.3    Serrano, M.4    Wölfel, C.5    Klehmann-Hieb, E.6    De Plaen, E.7    Hankeln, T.8    Meyer Zum Büschenfelde, K.-H.9    Beach, D.10
  • 67
    • 0030467624 scopus 로고    scopus 로고
    • The 'p16 - Cyclin D/Cdk4 - PRb' pathway as a functional unit frequently altered in melanoma pathogenesis
    • in press
    • Bartkova J, Lukas J, Guldberg P, Alsner J, Kirkin AF, Zeuthen J, Bartek J. The 'p16 - cyclin D/Cdk4 - pRb' pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res. 1996;. in press.
    • (1996) Cancer Res
    • Bartkova, J.1    Lukas, J.2    Guldberg, P.3    Alsner, J.4    Kirkin, A.F.5    Zeuthen, J.6    Bartek, J.7
  • 68
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • of special interest. Provides the first demonstration that hypermethylation of the 5′ CpG islands of the p16 gene may represent an additional, and relatively frequent, mechanism of inactivating this tumour suppressor gene in human cancers.
    • Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. of special interest Nat Med. 1:1995;686-692 Provides the first demonstration that hypermethylation of the 5′ CpG islands of the p16 gene may represent an additional, and relatively frequent, mechanism of inactivating this tumour suppressor gene in human cancers.
    • (1995) Nat Med , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 69
    • 0029808234 scopus 로고    scopus 로고
    • Enhanced protein stability: A novel mechanism of D-type cyclin overabundance identified in human sarcoma cells
    • Welcker M, Lukas J, Strauss M, Bartek J. Enhanced protein stability: a novel mechanism of D-type cyclin overabundance identified in human sarcoma cells. Oncogene. 13:1996;419-425.
    • (1996) Oncogene , vol.13 , pp. 419-425
    • Welcker, M.1    Lukas, J.2    Strauss, M.3    Bartek, J.4
  • 70
    • 0028967830 scopus 로고
    • Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis
    • Bartkova J, Lukas J, Strauss M, Bartek J. Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene. 10:1995;775-778.
    • (1995) Oncogene , vol.10 , pp. 775-778
    • Bartkova, J.1    Lukas, J.2    Strauss, M.3    Bartek, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.