Insights into the functions of BRCA1 and BRCA2

Trends in Genetics

Volumn 16, Issue 2, 2000, Pages 69-74

  Welcsh, Piri L ^a   Owens, Kelly N ^a   King, Mary Claire ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER SUSCEPTIBILITY; CELL PROLIFERATION; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INACTIVATION; GENE SEQUENCE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVIEW; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ANIMALS; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CELL CYCLE; DNA REPAIR; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICE; MODELS, GENETIC; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034142268     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(99)01930-7     Document Type: Review

References (65)

1. Hall, J.M. et al. (1990) Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250, 1684-1689
2. Miki, Y. et al. (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71
3. Wooster, R. et al. (1995) Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789-792
4. Smith, S.A. et al. (1992) Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome. Nat. Genet. 2, 128-131
5. Rahman, N. and Stratton, M.R. (1998) The genetics of breast cancer susceptibility. Annu. Rev. Genet 32, 95-121
6. Scully, R. et al. (1997) Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275
7. Chen, J. et al. (1998) Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2, 317-328
8. Gowen, L.C. et al. (1998) BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science 281, 1009-1012
9. Lee, H. et al. (1999) Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2. Mol. Cell 4, 1-10
10. Gowen, L.C. et al. (1996) Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat. Genet. 12, 191-194
11. Hakem, R. et al. (1996) The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85, 1009-1023
12. Liu, C.Y. et al. (1996) Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 10, 1835-1843
13. Sharan, S.K. et al. (1997) Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386, 804-810
14. Suzuki, A. et al. (1997) Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 11, 1242-1252
15. Ludwig, T. et al. (1997) Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 11, 1226-1241
16. Connor, F. et al. (1997) Tumorigenesis and a DNA-repair defect in mice with a truncating Brca2 mutation. Nat. Genet. 17, 423-430
17. Rajan, J.V. et al. (1997) Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev. Biol. 184, 385-401
18. Lorick, K.L. et al. (1999) RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl. Acad. Sci. U. S. A. 96, 11364-11369
19. Scully, R. et al. (1997) BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. U. S. A. 94, 5605-5610
20. Chapman, M.S. and Verma, I.M. (1996) Transcriptional activation by BRCA1. Nature 382, 678-679
21. Monteiro, A.N. et al. (1996) Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl. Acad. Sci. U. S. A. 93, 13595-13599
22. Milner, J. et al. (1997) Transcriptional activation functions in BRCA2. Nature 386, 772-773
23. Joazeiro, C.A. et al. (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286, 309-312
24. Wu, L.C. et al. (1996) Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat Genet. 14, 430-440
25. Meza, J.E. et al. (1999) Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1. J. Biol. Chem. 274, 5659-5665
26. Jensen, D.E. et al. (1998) BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogens 16, 1097-1112
27. Callebaut, I. and Mornon, J.P. (1997) From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett. 400, 25-30
28. Zhang, X. et al. (1998) Structure of an XRCC1 BRCT domain: a new protein-protein interaction module. EMBO J. 17, 6404-6411
29. Wong, A.K.C. et al. (1997) RAD51 interacts with the evolutionary conserved BRC motifs in the human breast cancer susceptibility gene brca2. J. Biol. Chem. 272, 31941-31944
30. Bertwistle, D. et al. (1997) Nuclear location and cell cycle regulation of the BRCA2 protein. Cancer Res. 57, 5485-5488
31. Wilson, C.A. et al. (1999) Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 21, 236-240
32. Jensen, R.A. et al. (1996) BRCA1 is secreted and exhibits properties of a granin. Nat Genet. 12, 303-308
33. Thakur, S. et al. (1997) Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol. Cell. Biol. 17, 444-452
34. McAllister, K.A. et al. (1997) Characterization of the rat and mouse homologues of the BRCA2 breast cancer susceptibility gene. Cancer Res. 57, 3121-3125
35. Chen, C.F. et al. (1996) The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor. J. Biol. Chem. 271, 32863-32868
36. Gudas, J.M. et al. (1996) Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells. Cell Growth Differ. 7, 717-723
37. Wang, S.C. et al. (1997) Changes in BRCA2 expression during progression of the cell cycle. Biochem. Biophys. Res. Commun. 234, 247-251
38. Ruffner, H. et al. (1999) BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. Mol. Cell. Biol. 19, 4843-4854
39. Aprelikova, O.N. et al. (1999) BRCA-associated growth arrest is RB-dependent. Proc. Natl. Acad. Sci. U. S. A. 96, 11866-11871
40. Xu, X. et al. (1999) Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell 3, 389-395
41. Hsu, L.C. and White, R.L. (1998) BRCA1 is associated with the centrosome during mitosis. Proc. Natl. Acad. Sci. U. S. A. 95, 12983-12988
42. Cahill, D.P. et al. (1998) Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300-303
43. Rajan, J.V. et al. (1996) Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 93, 13078-13083
44. Lim, D.S. and Hasty, P. (1996) A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell. Biol. 16, 7133-7143
45. Friedman, L.S. et al. (1998) Thymic lymphomas in mice with a truncating mutation in Brca2. Cancer Res. 58, 1338-1343
46. Shinohara, A. et al. (1992) Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell 69, 457-470
47. Zhong, Q. et al. (1999) Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science 285, 747-750
48. Scully, R. et al. (1997) Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90, 425-435
49. Cortez, D. et al. (1999) Requirement of ATM-dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks. Science 286, 1162-1166
50. Li, S. et al. (1999) Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. J. Biol. Chem. 274, 11334-11338
51. Harkin, D.P. et al. (1999) Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 97, 575-586
52. Hakem, R. et al. (1997) Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Nat. Genet. 16, 298-302
53. Cressman, V.L. et al. (1999) Mammary tumor formation in p53- and BRCA1-deficient mice. Cell Growth Differ. 10, 1-10
54. Xu, X. et al. (1999) Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat. Genet. 22, 37-43
55. Ramus, S.J. et al. (1999) Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian tumours. Genes Chromosomes Cancer 25, 91-96
56. Smith, P.D. et al. (1999) Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions. Oncogene 18, 2451-2459
57. Anderson, S.F. et al. (1998) BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat. Genet. 19, 254-256
58. Somasundaram, K. et al. (1997) Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature 389, 187-190
59. Ouchi, T. et al. (1998) BRCA1 regulates p53-dependent gene expression. Proc. Natl. Acad. Sci. U. S. A. 95, 2302-2306
60. Nordling, M. et al. (1998) A large deletion disrupts the exon 3 transcription activation domain of the BRCA2 gene in a breast/ovarian cancer family. Cancer Res. 58, 1372-1375
61. Marmorstein, L.Y. et al. (1998) The BRCA2 gene product functionally interacts with p53 and RAD51. Proc. Natl. Acad. Sci. U. S. A. 95, 13869-13874
62. Fan, S. et al. (1999) BRCA1 inhibition of estrogen receptor signaling in transfected cells. Science 284, 1354-1356
63. Yarden, R.I. and Brody, L.C. (1999) BRCA1 interacts with components of the histone deacetylase complex. Proc. Natl. Acad. Sci. U. S. A. 96, 4983-4988
64. Fuks, F. et al. (1998) BRCA2 associates with acetyltransferase activity when bound to P/CAF. Oncogene 17, 2531-2534
65. Brugarolas, J. and Jacks, T. (1997) Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair. Nat. Med. 3, 721-722