SCOPUS 정보 검색 플랫폼

Current Medicinal Chemistry

Volumn 8, Issue 9, 2001, Pages 1093-1122

Anticancer prodrugs for application in monotherapy: Targeting hypoxia, tumor-associated enzymes, and receptors

(3) de Groot, F M H a Damen, E W P a Scheeren, H W a

a RADBOUD UNIVERSITY NIJMEGEN (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; 5 (1 AZIRIDINYL) 3 HYDROXYMETHYL 2 (3 HYDROXY 1 PROPENYL) 1 METHYL 4,7 INDOLEDIONE; 8 HYDROXYQUINOLYL GLUCORINIDE; AMINOPEPTIDASE; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; AROMATIC NITRO COMPOUND; BETA GLUCURONIDASE; BLEOMYCIN; CARBAMIC ACID DERIVATIVE; CATHEPSIN; CHLORAMBUCIL; CISPLATIN; DACTINOMYCIN; DOXORUBICIN; ESTER DERIVATIVE; MELPHALAN METHYL ESTER; MITOMYCIN C; NITROIMIDAZOLE; NITROIMIDAZOLE CARBAMATE; NITROREDUCTASE; PACLITAXEL; PLASMIN; PRODRUG; PROSTATE SPECIFIC ANTIGEN; PROTEINASE; QUINONE DERIVATIVE; RB 6154; TIRAPAZAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANGIOGENESIS; ARTICLE; CANCER INVASION; CLINICAL TRIAL; CONJUGATE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TARGETING; EVALUATION; FEASIBILITY STUDY; HUMAN; HYPOXIA; LUNG NON SMALL CELL CANCER; MEDICAL LITERATURE; METASTASIS; MOLECULAR RECOGNITION; MOLECULAR WEIGHT; MONOTHERAPY; MOUSE; NONHUMAN; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR BINDING; SIDE EFFECT; SOLID TUMOR; TUMOR CELL; TUMOR GROWTH; TUMOR NECROSIS;

EID: 0034941481 PISSN: 09298673 EISSN: None Source Type: Journal
DOI: 10.2174/0929867013372634 Document Type: Article

Times cited : (119)

References (190)

1
- 0031843013
- (1998) Anticancer Res. , vol.18 , pp. 2905
- Volm, M.¹

2
- 0033180164
- (1999) Pharmacol. Ther. , vol.83 , pp. 67
- Dubowchik, G.M.¹ Walker, M.A.²

3
- 0028963579
- (1995) Drug Dev. Res. , vol.34 , pp. 220
- Bagshawe, K.D.¹

4
- 0024246527
- (1988) Br. J. Cancer , vol.58 , pp. 700
- Bagshawe, K.D.¹ Springer, C.J.² Searle, F.³ Antoniw, P.⁴ Sharma, S.K.⁵ Melton, R.G.⁶ Sherwood, R.F.⁷

5
- 0025858452
- (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8039
- Huber, B.E.¹ Richards, C.A.² Krentisky, T.A.³

6
- 0030865697
- (1997) Gene Therapy , vol.4 , pp. 791
- Lemmon, M.J.¹ Van Zijl, P.² Fox, M.E.³ Mauchline, M.L.⁴ Giaccia, A.J.⁵ Minton, N.P.⁶ Brown, J.M.⁷

7
- 0032857413
- (1999) S.T.P. Pharma Sciences , pp. 13
- Melton, R.¹ Connors, T.² Knox, R.J.³

8
- 0032897384
- (1999) Anticancer Research , vol.19 , pp. 605
- Syrigos, K.N.¹ Epenetos, A.A.²

9
- 0028030125
- (1994) Pharmac. Ther. , vol.64 , pp. 155
- Burrows, F.J.¹ Thorpe, P.E.²

10
- 0021632897
- (1985) Biochim. Biophys. Acta , vol.780 , pp. 151
- Begent, R.H.¹

11
- 0032489812
- (1998) Adv. Drug Delivery Reviews , vol.31 , pp. 89
- Chari, R.V.J.¹

12
- 0033106074
- (1999) Bioconjug. Chem. , vol.10 , pp. 279
- King, H.D.¹ Yurgaitis, D.² Willner, D.³ Firestone, R.A.⁴ Yang, M.B.⁵ Lasch, S.J.⁶ Hellström, K.E.⁷ Trail, P.A.⁸

13
- 0034060544
- (2000) Crit. Rev. Ther. Drug Carrier Systems , vol.17 , pp. 101
- Greenwald, R.B.¹ Conover, C.D.² Choe, Y.H.³

14
- 0032472802
- (1998) Adv. drug delivery rev. , vol.29 , pp. 249
- Forssen, E.¹ Willis, M.²

15
- 0343196666
- (1997) Adv. drug delivery rev. , vol.24 , pp. 235
- Maruyama, K.¹ Takizawa, T.² Takahashi, N.³ Tagawa, T.⁴ Nagaike, K.⁵ Iwatsuru, M.⁶

16
- 0032824375
- (1999) Adv. drug delivery rev. , vol.40 , pp. 89
- Maruyama, K.¹ Ishida, O.² Takizawa, T.³ Moribe, K.⁴

17
- 0034091694
- (2000) Eur. J. Cancer , vol.36 , pp. 942
- Vodovozova, E.L.¹ Moiseeva, E.V.² Grechko, G.K.³ Gayenko, G.P.⁴ Nifant'ev, N.E.⁵ Bovin, N.V.⁶ Molotkovsky, J.G.⁷

18
- 0032976042
- (1999) Critical Reviews in Therapeutic Drug Carrier Systems , vol.16 , pp. 245
- Kratz, F.¹ Beyer, U.² Schütte, M.T.³

19
- 0022576114
- (1986) Biochem. Soc. Trans. , vol.14 , pp. 375
- Wilman, D.E.V.¹

20
- 0343337640
- (1996) Advanced Drug Delivery Reviews , vol.19 , pp. 241
- Sinhababu, A.K.¹ Thakker, D.R.²

21
- 0028174228
- (1994) Int. J. Cancer , vol.56 , pp. 874
- Prezioso, J.A.¹ Hughey, R.P.² Wang, N.³ Damodaran, K.M.⁴ Bloomer, W.D.⁵

22
- 0018082885
- (1978) Biochemie , vol.60 , pp. 979
- Connors, T.A.¹

23
- 84908759321
- (1983) Development of Target-oriented Anticancer Drugs , pp. 143
- Carl, P.L.¹

24
- 0024408986
- (1989) Cancer Res. , vol.49 , pp. 6449
- Vaupel, P.¹ Kallinowski, F.² Okunieff, P.³

25
- 0033405294
- (1999) Cancer Res. , vol.59 , pp. 5863
- Brown, J.M.¹

26
- 0034176782
- (2000) Mol. Med. Today , vol.6 , pp. 157
- Brown, J.M.¹

27
- 0031742631
- (1998) Int. J. Rad. Oncol. Biol. Phys. , vol.42 , pp. 755
- Rauth, A.M.¹ Melo, T.² Misra, V.³

28
- 0004580887
- (1987) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5978
- Rice, G.C.¹ Hoy, C.² Schimke, R.T.³

29
- 0004610786
- (1996) Cancer Res. , vol.56 , pp. 941
- Reynolds, T.Y.¹ Rockwell, S.² Glazer, P.M.³

30
- 0031688165
- (1998) Br. J. Cancer , vol.78 , pp. 822
- Sundfor, K.¹ Lyng, H.² Rofstad, E.K.³

31
- 0026485002
- (1992) Nature , vol.359 , pp. 843
- Schweiki, D.¹ Itin, A.² Soffer, D.³ Keshet, E.⁴

32
- 0027219332
- (1993) Cancer Metast. Rev. , vol.12 , pp. 135
- Denny, W.A.¹ Wilson, W.R.²

33
- 0027295491
- (1993) Cancer Metast. Rev. , vol.12 , pp. 83
- Ross, D.¹ Siegel, D.² Beall, H.³ Prakash, A.S.⁴ Mulcahy, R.T.⁵ Gibson, N.W.⁶

34
- 0027182862
- (1993) Cancer Metastat. Rev. , vol.12 , pp. 195
- Knox, R.J.¹ Friedlos, F.² Boland, M.P.³

35
- 0028090161
- (1994) J. Med. Chem. , vol.37 , pp. 3452
- Mauger, A.B.¹ Burke, P.J.² Somani, H.H.³ Friedlos, F.⁴ Knox, R.J.⁵

36
- 0033590267
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 3417
- Hay, M.P.¹ Wilson, W.R.² Denny, W.A.³

37
- 0030865697
- (1997) Gene Ther. , vol.4 , pp. 791
- Lemmon, M.J.¹ Van Zijl, P.² Fox, M.E.³ Mauchline, M.L.⁴ Giaccia, A.J.⁵ Minton, N.P.⁶ Brown, J.M.⁷

38
- 0027288316
- (1993) Br. J. Cancer , vol.67 , pp. 1163
- Brown, J.M.¹

39
- 0027220811
- (1993) Cancer Metast. Rev. , vol.12 , pp. 119
- Patterson, L.H.¹

40
- 0031306972
- (1997) Oncol. Res. , vol.9 , pp. 357
- Siim, B.G.¹ Denny, W.A.² Wilson, W.R.³

41
- 0031709081
- (1998) Anti-Cancer Drug Des. , vol.13 , pp. 593
- Jaffar, M.¹ Naylor, M.A.² Robertson, N.³ Stratford, I.J.⁴

42
- 0004548971
- WO 87/06227.
- (1987) Int. Patent
- Speckamp, W.N.¹ Oostveen, E.N.²

43
- 0030271681
- (1996) Eur. J. Cancer , vol.32 A , pp. 2019
- Dirix, L.Y.¹ Tonnesen, F.² Cassidy, J.³ Epelbaum, R.⁴ Ten Bokkel Huinink, W.W.⁵ Pavlidis, N.⁶ Sorio, R.⁷ Gamucci, T.⁸ Wolff, I.⁹

44
- 0031930369
- (1998) Anti-Cancer Drug Des. , vol.13 , pp. 105
- Jaffar, M.¹ Naylor, M.A.² Robertson, N.³ Lockyer, S.D.⁴ Philips, R.M.⁵ Everett, S.A.⁶ Adams, G.E.⁷ Stratford, I.J.⁸

45
- 0032945037
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 113
- Jaffar, M.¹ Everett, S.A.² Naylor, M.A.³ Moore, S.G.⁴ Ulhaq, S.⁵ Patel, K.B.⁶ Sratford, M.R.L.⁷ Nolan, J.⁸ Wardman, P.⁹

46
- 0004629810
- WO99/48860.
- (1999) Int. Patent
- Boyle, F.T.¹

47
- 0034102257
- (2000) Exp. Opin. Ther. Patents , vol.10 , pp. 507

48
- 0032447565
- (1998) Med. Chem. Res. , vol.8 , pp. 444
- Gharat, L.¹ Visser, P.² Brummelhuis, M.³ Guiles, R.⁴ Chikhale, P.⁵

49
- 0034144552
- (2000) Drug Res. Updates. , vol.3 , pp. 7
- Brown, J.M.¹

50
- 0026802366
- (1992) Cancer Res. , vol.52 , pp. 4473
- Wang, J.¹ Biedermann, K.A.² Brown, J.M.³

51
- 0032717495
- (1999) Xenobiotica , vol.29 , pp. 1115
- Raleigh, S.M.¹ Wanogho, E.² Burke, M.D.³ Patterson, L.H.⁴

52
- 0029935930
- (1996) Br. J. Cancer , vol.74 , Issue.SUPPL. XXVII
- Wilson, W.R.¹ Denny, W.A.² Pullen, S.M.³ Thompson, K.M.⁴ Li, A.E.⁵ Patterson, L.H.⁶ Lee, H.H.⁷

53
- 0031742538
- (1998) Int. J. Rad. Oncol. Biol. Phys. , vol.42 , pp. 763
- Raleigh, S.M.¹ Wanogho, E.² Burke, M.D.³ McKeown, S.R.⁴ Patterson, L.H.⁵

54
- 0029783393
- (1996) Anti-Cancer Drug Des. , vol.11 , pp. 421
- Henderson, N.D.¹ Plumb, J.A.² Robins, D.J.³ Workman, P.⁴

55
- 0024427760
- (1989) Carcinogenesis , vol.10 , pp. 2113
- White, I.N.H.¹ Suzanger, M.² Mattocks, A.R.³ Bailey, E.⁴ Farmer, P.B.⁵ Connors, T.A.⁶

56
- 37049083007
- (1991) J. Chem. Soc., Perkin Trans. I , pp. 2961
- Mann, J.¹ Shervington, L.A.²

57
- 84889345087
- (1999) J. Chem. Soc., Perkin Trans I , pp. 2343
- Highfield, J.A.¹ Metha, L.K.² Parrick, J.³ Candeias, L.P.⁴ Wardman, P.⁵

58
- 0032558483
- (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 2609
- Highfield, J.A.¹ Metha, L.K.² Parrick, J.³ Candeias, L.P.⁴ Wardman, P.⁵

59
- 0031306972
- (1997) Oncol. Res. , vol.9 , pp. 357
- Siim, B.G.¹ Denny, W.A.² Wilson, W.R.³

60
- 0025023154
- (1990) J. Med. Chem. , vol.33 , pp. 2603
- Jenkins, T.C.¹ Naylor, M.A.² O'Neill, P.³ Threadgill, M.D.⁴ Cole, S.⁵ Stratford, I.J.⁶ Adams, G.E.⁷ Fielden, E.M.⁸ Suto, M.J.⁹ Stier, M.A.¹⁰

61
- 0029583504
- (1995) Br. J. Cancer , vol.72 , pp. 1479
- Skarsgard, L.D.¹ Acheson, D.K.² Vinczan, A.³ Wouters, B.G.⁴ Heinrichs, B.E.⁵ Loblaw, D.A.⁶ Minchinton, A.I.⁷ Chaplin, D.J.⁸

62
- 0034652379
- (2000) Tox. Appl. Pharmacol. , vol.163 , pp. 50
- Lee, A.E.¹ Wilson, W.R.²

63
- 0032972169
- (1999) J. Med. Chem. , vol.42 , pp. 346
- Sykes, B.M.¹ Atwell, G.J.² Hogg, A.³ Wilson, W.R.⁴ O'Connor, C.J.⁵ Denny, W.A.⁶

64
- 0001662224
- (1999) J. Chem. Soc. Perkin Trans. I , pp. 2759
- Hay, M.P.¹ Sykes, B.M.² Denny, W.A.³ O'Connor, C.J.⁴

65
- 0017813974
- (1978) J. Am. Chem. Soc. , vol.100 , pp. 313
- Johnston, D.B.R.¹ Schmitt, S.M.² Boufford, F.A.³ Christensen, B.G.⁴

66
- 0028090161
- (1994) J. Med. Chem. , vol.37 , pp. 3452
- Mauger, A.B.¹ Burke, P.J.² Somani, H.H.³ Friedlos, F.⁴ Knox, R.J.⁵

67
- 0033590267
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 3417
- Hay, M.P.¹ Wilson, W.R.² Denny, W.A.³

68
- 0033545676
- (1999) J. Med. Chem. , vol.42 , pp. 941
- Shyam, K.¹ Penketh, P.G.² Shapiro, M.³ Belcourt, M.F.⁴ Loomis, R.H.⁵ Rockwell, S.⁶ Sartorelli, A.C.⁷

69
- 0034692163
- (2000) J. Med. Chem. , vol.43 , pp. 1484
- Reynolds, R.C.¹ Tiwari, A.² Harwell, J.E.³ Gordon, D.G.⁴ Garrett, B.D.⁵ Gilbert, K.S.⁶ Schmid, S.M.⁷ Waud, W.R.⁸ Struck, R.F.⁹

70
- 0033519175
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 1267
- Everett, S.A.¹ Naylor, M.A.² Patel, K.B.³ Stratford, M.R.L.⁴ Wardman, P.⁵

71
- 0033584157
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 2031
- Parveen, I.¹ Naughton, D.P.² Whish, W.J.D.³ Threadgill, M.D.⁴

72
- 0034695519
- (2000) Tetrahedron , vol.56 , pp. 645
- Hay, M.P.¹ Wilson, W.² Denny, W.A.³

73
- 0033516908
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 2237
- Hay, M.P.¹ Sykes, B.M.² Denny, W.A.³ Wilson, W.R.⁴

74
- 33749093333
- (1997) J. Chem. Soc., Perkin Trans. 1 , pp. 1147
- Berry, J.M.¹ Watson, C.Y.² Whish, W.J.D.³ Threadgill, M.D.⁴

75
- 0032842684
- (1999) Anti-Cancer Drug Des. , vol.14 , pp. 231
- Perrin, L.C.¹ Wilson, W.R.² Dennny, W.A.³ McFadyen, W.D.⁴

76
- 0002934074
- (1996) J. Chem. Soc. Perkin Trans. 1 , pp. 1205
- Griffin, R.J.¹ Evers, E.² Davison, R.³ Gibson, A.E.⁴ Layton, D.⁵ Irwin, W.J.⁶

77
- 0026721021
- (1992) J. Med. Chem. , vol.35 , pp. 2137
- Kwon, C.-H.¹ Blanco, D.R.² Baturay, N.³

78
- 0030751284
- (1997) Clin. Pharmacokinet. , vol.33 , pp. 18
- Sperker, B.¹ Backman, J.T.² Kroemer, H.K.³

79
- 0014024073
- (1966) Nature , vol.210 , pp. 866
- Connors, T.A.¹ Whisson, M.E.²

80
- 0017397510
- (1977) Cancer Treat. Rep. , vol.61 , pp. 909
- Double, J.A.¹ Workman, P.²

81
- 0017167325
- (1976) Cancer , vol.38 , pp. 1887
- Young, C.W.¹ Yagoda, A.² Bittar, E.S.³

82
- 0032521438
- (1998) Cancer Res. , vol.58 , pp. 1195
- Bosslet, K.¹ Straub, R.² Blumrich, M.³ Czech, J.⁴ Gerken, M.⁵ Sperker, B.⁶ Kroemer, H.K.⁷ Gesson, J.-P.⁸ Koch, M.⁹ Monneret, C.¹⁰

83
- 0033566279
- (1999) Biochem. Pharmacol. , vol.58 , pp. 325
- Cheng, T.L.¹ Chou, W.C.² Chen, B.M.³ Chern, J.W.⁴ Roffler, S.R.⁵

84
- 0023789073
- (1988) Radiat. Res. , vol.115 , pp. 373
- Henle, K.J.¹ Monson, T.P.² Nagle, W.A.³ Moss, A.J.⁴

85
- 0025936081
- (1991) Biochem. Pharmacol. , vol.42 , pp. 2062
- Roffler, S.R.¹ Wang, S.-M.² Chern, J.-W.³ Yeh, M.-Y.⁴ Tung, E.⁵

86
- 0030698257
- (1997) Int. J. Cancer , vol.73 , pp. 392
- Chen, B.M.¹ Chan, L.Y.² Wang, S.M.³ Wu, M.F.⁴ Chern, J.W.⁵ Roffler, S.R.⁶

87
- 0028718114
- (1994) Cell Biophys. , vol.24-25 , pp. 185
- Haisma, H.J.¹ van Muijen, M.² Pinedo, H.M.³ Boven, E.⁴

88
- 0028788630
- (1995) Bioorg. Med. Chem., Lett. , vol.5 , pp. 2975
- Leenders, R.G.G.¹ Scheeren, H.W.² Houba, P.H.J.³ Boven, E.⁴ Haisma, H.J.⁵

89
- 0019453510
- (1981) J. Med. Chem. , vol.24 , pp. 479
- Carl, P.L.¹ Chakravarty, P.K.² Katzenellenbogen, J.A.³

90
- 0000231181
- (1983) New J. Chem. , vol.7 , pp. 439
- Wakselman, M.¹

91
- 15144361344
- (1998) J. Med. Chem. , vol.41 , pp. 3572
- Florent, J.-C.¹ Dong, X.² Gaudel, G.³ Mitaku, S.⁴ Monneret, C.⁵ Gesson, J.-P.⁶ Jacquesy, J.-C.⁷ Mondon, M.⁸ Renoux, B.⁹ Andrianomenjanahary, S.¹⁰ Michel, S.¹¹ Koch, M.¹² Tillequin, F.¹³ Gerken, M.¹⁴ Czech, J.¹⁵ Straub, R.¹⁶ Bosslet, K.¹⁷

92
- 0001874589
- (1995) Tumor Targeting , vol.1 , pp. 45
- Bosslet, K.¹ Czech, J.² Hoffman, D.³

93
- 14444281990
- (1997) Cancer Res. , vol.57 , pp. 2440
- Mürdter, T.E.¹ Sperker, B.² Kivistö, K.T.³ McClellan, M.⁴ Fritz, P.⁵ Friedel, G.⁶ Linder, A.⁷ Bosslet, K.⁸ Toomes, H.⁹ Dierkesmann, R.¹⁰ Kroemer, H.K.¹¹

94
- 0032833334
- (1999) Br. J. Cancer , vol.81 , pp. 24
- Platel, D.¹ Bonoron-Adèle, S.² Dix, R.K.³ Robert, J.⁴

95
- 0032440521
- (1998) Anti-Cancer Drug Des. , vol.13 , pp. 955
- Desbène, S.¹ Dufat-Trinh Van, H.² Michel, S.³ Koch, M.⁴ Tillequin, F.⁵ Fournier, G.⁶ Farjaudon, N.⁷ Monneret, C.⁸

96
- 0028918023
- (1995) Tetrahedron Lett , vol.26 , pp. 1701
- Leenders, R.G.G.¹ Gerrits, K.A.A.² Ruijtenbeek, R.³ Scheeren, H.W.⁴ Haisma, H.J.⁵ Boven, E.⁶

97
- 0001144402
- (1996) Biochem. Pharmacol. , vol.52 , pp. 455
- Houba, P.H.J.¹ Leenders, R.G.G.² Boven, E.³ Scheeren, J.W.⁴ Pinedo, H.M.⁵ Haisma, H.J.⁶

98
- 0031081690
- (1997) Bioorg. Med. Chem. , vol.5 , pp. 405
- Bont de, D.B.A.¹ Leenders, R.G.G.² Haisma, H.J.³ van der Meulen-Muileman, I.⁴ Scheeren, J.W.⁵

99
- 0032802060
- (1999) Bioorg. Med. Chem. , vol.7 , pp. 1597
- Leenders, R.G.G.¹ Damen, E.W.P.² Bijsterveld, E.J.A.³ Scheeren, J.W.⁴ Houba, P.H.J.⁵ van der Meulen-Muileman, I.H.⁶ Boven, E.⁷ Haisma, H.J.⁸

100
- 0031739137
- (1998) Br. J. Cancer , vol.78 , pp. 1600
- Houba, P.H.J.¹ Boven, E.² Erkelens, C.A.M.³ Leenders, R.G.G.⁴ Scheeren, J.W.⁵ Pinedo, H.M.⁶ Haisma, H.J.⁷

101
- 0033559861
- (1999) Biochem. Pharmacol. , vol.57 , pp. 673
- Houba, P.H.J.¹ Boven, E.² van der Meulen-Muileman, I.H.³ Leenders, R.G.G.⁴ Scheeren, J.W.⁵ Pinedo, H.M.⁶ Haisma, H.J.⁷

102
- 0032558480
- (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 2545
- Papot, S.¹ Combaud, D.² Gesson, J.-P.³

103
- 0031457848
- (1997) J. Med. Chem. , vol.40 , pp. 4013
- Bakina, E.¹ Wu, Z.² Rosenblum, M.³ Farquhar, D.⁴

104
- 0033539166
- (1999) J. Med. Chem. , vol.42 , pp. 3623
- Leu, Y.-L.¹ Roffler, S.R.² Chern, J.-W.³

105
- 0004579292
- The camptothecins. From discovery to the patient. The New York Academy of Sciences: New York
- (1996)
- Pantazis, P.¹ Giovanella, B.C.² Rothenberg, M.L.³

106
- 0030950486
- (1997) Bioorg. Med. Chem. Lett. , vol.7 , pp. 1071
- Schmidt, F.¹ Florent, J.-C.² Monneret, C.³ Straub, R.⁴ Czech, J.⁵ Gerken, M.⁶ Bosslet, K.⁷

107
- 0032410355
- (1998) Anti-Cancer Drug Des. , vol.13 , pp. 995
- Lougerstay-Madec, R.¹ Florent, J.-C.² Monneret, C.³ Nemati, F.⁴ Poupon, M.F.⁵

108
- 0000819461
- (1999) J. Chem. Soc., Perkin Trans 1 , pp. 1369
- Madec-Lougerstay, R.¹ Florent, J.-C.² Monneret, C.³

109
- 0030783693
- (1997) Tetrahedron Lett. , vol.38 , pp. 8795
- Ghosh, A.K.¹ Farquhar, D.²

110
- 0030896534
- (1997) Int. J. Oncol. , vol.10 , pp. 807
- Yamashita, J.-I.¹ Ogawa, M.²

111
- 0031733174
- (1998) Int. J. Oncol. , vol.13 , pp. 893
- Ruening, U.¹ Magdolen, V.² Wilhelm, O.³ Fischer, K.⁴ Lutz, V.⁵ Graeff, H.⁶ Schmitt, M.⁷

112
- 0034047457
- (2000) Fibrin. Proteol. , vol.14 , pp. 87
- Ghosh, S.¹ Ellerbroek, S.M.² Wu, Y.³ Stack, M.S.⁴

113
- 0027535914
- (1993) Physiol. Rev. , vol.73 , pp. 161
- Mignatti, P.¹ Rifkin, D.B.²

114
- 0034651996
- (2000) Clin. Chim. Acta , vol.291 , pp. 113
- Koblinski, J.E.¹ Ahram, M.² Sloane, B.F.³

115
- 0034124218
- (2000) Fibrin. Proteol. , vol.14 , pp. 175
- Lijnen, H.R.¹

116
- 0033981473
- (2000) Cell. Mol. Life Sci. , vol.57 , pp. 25
- Andreasen, P.A.¹ Egelund, R.² Petersen, H.H.³

117
- 0028979473
- (1995) Biochem. Pharmacol. , vol.49 , pp. 567
- Smal, M.A.¹ Dong, Z.² Cheung, H.T.A.³ Asano, Y.⁴ Escoffier, L.⁵ Costello, M.⁶ Tattersall, M.H.N.⁷

118
- 0027461740
- (1993) Cancer Res. , vol.53 , pp. 1450
- Menrad, A.¹ Speicher, D.² Wacker, J.³ Herlyn, M.⁴

119
- 0027195127
- (1993) Int. J. Cancer , vol.54 , pp. 137
- Saiki, I.¹ Fujii, H.² Yoneda, J.³ Abe, F.⁴ Nakajima, M.⁵ Tsuruo, T.⁶ Azuma, I.⁷

120
- 0030728733
- (1997) Cancer Res. , vol.57 , pp. 4924
- Denmeade, S.R.¹ Lou, W.² Malm, J.³ Lövgren, J.⁴ Lilja, H.⁵ Isaacs, J.T.⁶

121
- 0032526152
- (1998) Cancer Res. , vol.58 , pp. 2537
- Denmeade, S.R.¹ Nagy, A.² Gao, J.³ Lilja, H.⁴ Schally, A.V.⁵ Isaacs, J.T.⁶

122
- 0001891257
- (1996) Persp. Drug Disc. Design , vol.6 , pp. 12
- Elliott, E.¹ Sloane, B.F.²

123
- 0033951243
- (2000) Br. J. Cancer , vol.82 , pp. 931
- van Noorden, C.J.F.¹ Jonges, T.G.N.² Meade-Tollin, L.C.³ Smith, R.E.⁴ Koehler, A.⁵

124
- 0027050399
- (1992) Br. J. Cancer , vol.66 , pp. 1044
- Boven, E.¹ Hendriks, H.R.² Erkelens, C.A.M.³ Pinedo, H.M.⁴

125
- 0032169889
- (1998) Eur. J. Cancer , vol.34 , pp. 1602
- Breistol, K.¹ Hendriks, H.R.² Berger, D.P.³ Langdon, S.P.⁴ Fiebig, H.H.⁵ Fodstad, O.⁶

126
- 0001354236
- (1999) Eur. J. Cancer , vol.35 , pp. 1143
- Breistol, K.¹ Hendriks, H.R.² Fodstad, O.³

127
- 0029941746
- (1996) Nat. Biotechnol. , vol.14 , pp. 852
- Panchal, R.G.¹ Cusack, E.² Cheley, S.³ Bayley, H.⁴

128
- 0030792535
- (1997) Tet. Lett. , vol.38 , pp. 5257
- Dubowchik, G.M.¹ Radia, S.²

129
- 0032402354
- (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 3341
- Dubowchik, G.M.¹ Firestone, R.A.²

130
- 0032402572
- (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 3347
- Dubowchik, G.M.¹ Mosure, K.² Knipe, J.O.³ Firestone, R.A.⁴

131
- 12944328659
- (2000) Fibrin. Proteol. , vol.14 , pp. 114
- Schmitt, M.¹ Wilhelm, O.G.² Reuning, U.³ Krüger, A.⁴ Harbeck, N.⁵ Lengyel, E.⁶ Graeff, H.⁷ Gänsbacher, B.⁸ Kessler, H.⁹ Bürgle, M.¹⁰ Stürzebecher, J.¹¹ Sperl, S.¹² Magdolen, V.¹³

132
- 0030896534
- (1997) Int. J. Oncol. , vol.10 , pp. 807
- Yamashita, Y.-I.¹ Ogawa, M.²

133
- 0033213996
- (1999) Cell. Mol. Life Sci. , vol.56 , pp. 104
- Irigoyen, J.P.¹ Muñoz-Cánoves, P.² Montero, L.³ Koziczak, M.⁴ Nagamine, Y.⁵

134
- 0029894671
- (1996) Enzym. & Prot. , vol.49 , pp. 163
- Hewitt, R.¹ Danø, K.²

135
- 0001524502
- (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 2224
- Carl, P.L.¹ Chakravarty, P.K.² Katzenellenbogen, J.A.³ Weber, M.J.⁴

136
- 0020607978
- (1983) J. Med. Chem. , vol.26 , pp. 633
- Chakravarty, P.K.¹ Carl, P.L.² Weber, M.J.³ Katzenellenbogen, J.A.⁴

137
- 0020644940
- (1983) J. Med. Chem. , vol.26 , pp. 638
- Chakravarty, P.K.¹ Carl, P.L.² Weber, M.J.³ Katzenellenbogen, J.A.⁴

138
- 0026758806
- (1992) J. Med. Chem. , vol.35 , pp. 3344
- Balajthy, Z.¹ Aradi, J.² Kiss, I.T.³ Elödi, P.⁴

139
- 0000315290
- Reduction of anticancer drug toxicity. Pharmacologic, biologic, immunologic and gene therapeutic approaches; Zeller, W. J.; Eisenbrand, G.; Hellmann, K. (Eds), Basel, Karger
- (1995) Contrib. Oncol. , vol.48 , pp. 189
- Lauck-Birkel, S.¹ Tang, W.C.² Wagner, B.³ Fiebig, H.H.⁴ Kohlmüller, D.⁵ Eisenbrand, G.⁶

140
- 0029839133
- (1996) Synthesis , pp. 1246
- Eisenbrand, G.¹ Lauck-Birkel, S.² Tang, W.C.³

141
- 0033576644
- (1999) J. Med. Chem. , vol.42 , pp. 5277
- de Groot, F.M.H.¹ de Bart, A.C.W.² Verheijen, J.H.³ Scheeren, H.W.⁴

142
- 0034632849
- (2000) J. Med. Chem. , vol.43 , pp. 3093
- de Groot, F.M.H.¹ van Berkom, L.W.A.² Scheeren, H.W.³

143
- 0032531883
- (1998) Int. J. Pharmaceutics , vol.172 , pp. 1
- Panchagnula, R.¹

144
- 0034088338
- (2000) Exp. Opin. Ther. Pat. , vol.10 , pp. 869
- Lin, S.¹ Ojima, I.²

145
- 0025016905
- (1990) J. Med. Chem. , vol.33 , pp. 97
- Saari, W.S.¹ Schwering, J.E.² Lyle, P.A.³ Smith, S.J.⁴ Engelhardt, E.L.⁵

146
- 0343673806
- (2000) Cancer Treatment Rev. , vol.26 , pp. 191
- Eatock, M.M.¹ Schätzlein, A.² Kaye, S.B.³

147
- 0242527761
- (1999) Cell. Mol. Life Sci. , vol.56 , pp. 427
- Curley, G.P.¹ Blum, H.² Humphries, M.E.³

148
- 0028899525
- (1995) Biotechnology , vol.13 , pp. 265
- Koivunen, E.¹ Wang, B.² Ruoslahti, E.³

149
- 0032535999
- (1998) Science , vol.279 , pp. 377
- Arap, W.¹ Pasqualini, R.² Ruoslahti, E.³

150
- 0033551899
- (1999) Science , vol.285 , pp. 1028
- Giancotti, F.G.¹ Ruoslahti, E.²

151
- 0029775681
- (1996) Annu. Rev. Cell Dev. Biol. , vol.12 , pp. 697
- Ruoslahti, E.¹

152
- 0028362876
- (1994) Science , vol.264 , pp. 569
- Brooks, P.C.¹ Clark, R.A.F.² Cheresh, D.A.³

153
- 0032721665
- (1999) Proc. Soc. Exp. Biol. Med. , vol.222 , pp. 124
- Mizejewski, G.J.¹

154
- 0033969626
- (2000) Cell. Mol. Life Sci. , vol.57 , pp. 16
- Ivaska, J.¹ Heino, J.²

155
- 0033950895
- (2000) Cancer Res. , vol.60 , pp. 722
- Pasqualini, R.¹ Koivunen, E.² Kain, R.³ Lahdenranta, J.⁴ Sakamoto, M.⁵ Stryhn, A.⁶ Ashmun, R.A.⁷ Shapiro, L.H.⁸ Arap, W.⁹ Ruoslahti, E.¹⁰

156
- 0032819838
- (1999) Nature Med. , vol.5 , pp. 1032
- Ellerby, H.M.¹ Arap, W.² Ellerby, L.M.³ Kain, R.⁴ Andrusiak, R.⁵ Del Rio, G.⁶ Krajewski, S.⁷ Lombardo, C.R.⁸ Rao, R.⁹ Ruoslahti, E.¹⁰ Bredesen, D.E.¹¹ Pasqualini, R.¹²

157
- 0033564799
- (1999) Cancer Res. , vol.59 , pp. 2869
- Burg, M.A.¹ Pasqualini, R.² Arap, W.³ Ruoslahti, E.⁴ Stallcup, W.B.⁵

158
- 0025949661
- (1991) Cancer Res. , vol.51 , pp. 5329
- Campbell, I.G.¹ Jones, T.A.² Foulkes, W.D.³ Trowsdale, J.⁴

159
- 0343882023
- (2000) Advanced Drug Delivery Rev. , vol.41 , pp. 147
- Sudimack, J.¹ Lee, R.J.²

160
- 0032439486
- (1998) Critical Rev. Ther. Drug Carrier Systems , vol.15 , pp. 587
- Reddy, J.A.¹ Low, P.S.²

161
- 0033378420
- (1999) J. Drug Targeting , vol.7 , pp. 157
- Leamon, C.P.¹ DePrince, R.B.² Hendren, R.W.³

162
- 0026496180
- (1992) J. Biol. Chem. , vol.267 , pp. 24966
- Leamon, C.P.¹ Low, P.S.²

163
- 0027423248
- (1993) J. Biol. Chem. , vol.268 , pp. 24847
- Leamon, C.P.¹ Pastan, I.² Low, P.S.³

164
- 0031564203
- (1997) Int. J. Cancer , vol.73 , pp. 859
- Ladino, C.A.¹ Chari, R.V.J.² Bourret, L.A.³ Kedersha, N.L.⁴ Goldmacher, V.S.⁵

165
- 0031683544
- (1998) Pharm. Res. , vol.15 , pp. 1540
- Li, S.¹ Deshmukh, H.M.² Huang, L.³

166
- 0034128393
- (2000) J. Drug Targeting , vol.8 , pp. 119
- Ward, C.M.¹ Acheson, N.² Seymour, L.W.³

167
- 0032797051
- (1999) Eur. J. Endocrin. , vol.141 , pp. 1
- Schally, A.V.¹ Nagy, N.²

168
- 0024394097
- (1989) Internat. Urol. Nephrol. , vol.21 , pp. 393
- Konyves, I.¹

169
- 0021344478
- (1984) Prostate , vol.5 , pp. 55
- Konyves, I.¹ Muntzing, J.² Rozencweig, M.³

170
- 0021891363
- (1985) Methods in Enzymology , vol.112 , pp. 259
- Varga, J.M.¹

171
- 0004608376
- (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 6313
- Bajusz, S.¹ Janáky, T.² Csernus, V.J.³ Bokser, L.⁴ Fekete, M.⁵ Srkalovic, G.⁶ Redding, T.W.⁷ Schally, A.V.⁸

172
- 0004584797
- (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 6318
- Bajusz, S.¹ Janáky, T.² Csernus, V.J.³ Bokser, L.⁴ Fekete, M.⁵ Srkalovic, G.⁶ Redding, T.W.⁷ Schally, A.V.⁸

173
- 0026503015
- (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 972
- Janáky, T.¹ Juhász, A.² Bajusz, S.³ Csernus, V.J.⁴ Srkalovic, G.⁵ Bokser, L.⁶ Milovanovic, S.⁷ Redding, T.W.⁸ Rékási, Z.⁹ Nagy, A.¹⁰ Schally, A.V.¹¹

174
- 0027432237
- (1993) Prostate , vol.23 , pp. 165
- Pinski, J.¹ Schally, A.V.² Yano, T.³ Szepeshazi, K.⁴ Halmos, G.⁵ Groot, K.⁶ Comaru-Schally, A.M.⁷ Radulovic, S.⁸ Nagy, A.⁹

175
- 8944225497
- (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7269
- Nagy, A.¹ Schally, A.V.² Armatis, P.³ Szepeshazi, K.⁴ Halmos, G.⁵ Kovacs, M.⁶ Zarandi, M.⁷ Groot, K.⁸ Miyazaki, M.⁹ Jungwirth, A.¹⁰ Horvath, J.¹¹

176
- 0034681171
- (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 829
- Nagy, A.¹ Plonowski, A.² Schally, A.V.³

177
- 0345304646
- (1999) Am. J. Obstet. Gynecol. , vol.180 , pp. 1095
- Miyazaki, M.¹ Schally, A.V.² Nagy, A.³ Lamharzi, N.⁴ Halmos, G.⁵ Szepeshazi, K.⁶ Armatis, P.⁷

178
- 0030961688
- (1997) Int. J. Oncol. , vol.10 , pp. 877
- Jungwirth, A.¹ Schally, A.V.² Nagy, A.³ Pinski, J.⁴ Groot, K.⁵ Galvan, G.⁶ Szepeshazi, K.⁷ Halmos, G.⁸

179
- 0034010324
- (2000) Breast Cancer Res. Treatment , vol.59 , pp. 255
- Kahán, Z.¹ Nagy, A.² Schally, A.V.³ Halmos, G.⁴ Arencibia, J.M.⁵ Groot, K.⁶

180
- 0028352250
- (1994) Anticancer drugs , vol.5 , pp. 115
- Schally, A.V.¹

181
- 0031030324
- (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 652
- Nagy, A.¹ Armatis, P.² Cai, R.-Z.³ Szepeshazi, K.⁴ Halmos, G.⁵ Schally, A.V.⁶

182
- 0032744924
- (1999) Br. J. Cancer , vol.81 , pp. 966
- Kiaris, H.¹ Schally, A.V.² Nagy, A.³ Sun, B.⁴ Armatis, P.⁵ Szepeshazi, K.⁶

183
- 0032727981
- (1999) J. Med. Chem. , vol.42 , pp. 4919
- Safavy, A.¹ Raisch, K.P.² Khazaeli, M.B.³ Buchsbaum, D.J.⁴ Bonner, J.A.⁵

184
- 0026569101
- (1992) Cancer Lett. , vol.62 , pp. 263
- Radulovic, S.¹ Nagy, A.² Szoke, B.³ Schally, A.V.⁴

185
- 0032539609
- (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1794
- Nagy, A.¹ Schally, A.V.² Halmos, G.³ Armatis, P.⁴ Cai, R.Z.⁵ Csernus, V.⁶ Kovács, M.⁷ Koppán, M.⁸ Szepeshazi, K.⁹ Kahán, Z.¹⁰

186
- 0028102168
- (1994) Br. J. Cancer , vol.70 , pp. 401
- Sykes, E.¹ Woodburn, K.² Decker, D.³ Kessel, D.⁴

187
- 0028386492
- (1994) Bioconjug. Chem. , vol.5 , pp. 105
- Firestone, R.A.¹

188
- 0033200301
- (1999) Bioconjug. Chem. , vol.10 , pp. 755
- Luo, Y.¹ Prestwich, G.D.²

189
- 0033013012
- (1999) J. Cont. Rel. , vol.57 , pp. 281
- Julyan, P.J.¹ Seymour, L.W.² Ferry, D.R.³ Daryani, S.⁴ Boivin, C.M.⁵ Doran, J.⁶ David, M.⁷ Anderson, D.⁸ Christodoulou, C.⁹ Young, A.M.¹⁰ Hesslewood, S.¹¹ Kerr, D.J.¹²

190
- 0032772050
- (1999) Pharm. Res. , vol.16 , pp. 1010
- Omelyanenko, V.¹ Kopecková, P.² Prakash, R.K.³ Ebert, C.D.⁴ Kopecek, J.⁵

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.