Synthesis and biological evaluation of 2'-carbamate-linked and 2'-carbonate-linked prodrugs of paclitaxel selective activation by the tumor-associated protease plasmin

Journal of Medicinal Chemistry

Volumn 43, Issue 16, 2000, Pages 3093-3102

  De Groot, F M H ^a   Van Berkom, L W A ^a   Scheeren, H W ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMIC ACID DERIVATIVE; PACLITAXEL; PACLITAXEL DERIVATIVE; PRODRUG;

ARTICLE; CHEMICAL BOND; CYCLIZATION; DRUG ACTIVATION; DRUG CYTOTOXICITY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; REACTION ANALYSIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROLYSIS; OLIGOPEPTIDES; PACLITAXEL; PLASMIN; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; TAXOIDS; TUMOR CELLS, CULTURED;

EID: 0034632849     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0009078     Document Type: Article

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