Design, synthesis, and in vitro evaluation of cytotoxic analogs of bombesin-like peptides containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 2, 1997, Pages 652-656

  Nagy, Attila ^a,b   Armatis, Patricia ^a   Cai, Ren Zhi ^a,b   Szepeshazi, Karoly ^a,b   Halmos, Gabor ^a,b   Schally, Andrew V ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

antiproliferative activity; hybrid molecules; receptor binding; targeted chemotherapeutic agents

Indexed keywords

BOMBESIN; CYTOTOXIC AGENT; DOXORUBICIN DERIVATIVE; PYRROLINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG CANCER; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; STOMACH CANCER;

BOMBESIN; CELL SURVIVAL; CYTOTOXINS; DOXORUBICIN; HUMANS; MOLECULAR STRUCTURE; PYRROLES; RECEPTORS, BOMBESIN; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0031030324     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.2.652     Document Type: Article

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