Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (adept): A phenol nitrogen mustard carbamate

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 8, 1997, Pages 1071-1076

  Schmidt, F ^a   Florent, J C ^a   Monneret, C ^a   Straub, R ^b   Czech, J ^b   Gerken, M ^b   Bosslet, K ^b  

^a CNRS   (France)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCURONIDASE; CHLORMETHINE DERIVATIVE; CYTOTOXIC AGENT; PRODRUG;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG METABOLISM; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; TUMOR CELL; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0030950486     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00157-1     Document Type: Article

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31. +
32. Studies of the potential biological properties of this compound are ongoing.